The Aster laboratory primarily studies Notch signaling in cancer. Ongoing projects seek to understand through use of ChIP-Seq and other comprehensive genome-wide approaches how Notch regulates the genomes of leukemia cells; how Notch activity is coordinated at the level of the genome with other transcription factors involved in T cell development and T cell transformation, as well as the components of the basal transcriptional machinery and regulators of histone marks; how post-translational modifications regulate Notch; and how Notch effects on leukemia cells are modified by interactions with bone marrow stromal cells. These studies are being conducted within the context of several multi-investigator projects, which foster close collaborations with investigators using structural, chemical, bioinformatic, and animal modeling approaches to study physiologic and pathophysiologic Notch signaling.