Our laboratory uses mouse molecular genetics, in vitro signaling approaches, circuit mapping, electrophysiological and behavioral analyses to gain understanding of the development, organization, and function of neural circuits that underlie the sense of touch. Mouse molecular genetic approaches are used to identify, visualize, and functionally manipulate each of the physiologically defined classes of low-threshold mechanosensory neurons (LTMRs), the primary cutaneous sensory neurons that mediate the sense of touch. We also strive to gain genetic access to spinal cord interneurons and projection neurons to reveal the organizational logic and functions of touch circuits in the spinal cord and brainstem. Our current goals are to discover: 1) the unique functions and properties of LTMR subtypes; 2) the organization of synaptic connections between LTMR subtypes, spinal cord dorsal horn interneurons and projection neurons, and dorsal column nuclei neurons; 3) the neural circuits that underlie the perception of touch; 4) molecular and developmental mechanisms by which primary somatosensory neurons and touch circuit organization are established; and 5) mechanisms of touch circuit dysfunction in mouse models of autism spectrum disorders and neuropathic pain.