Our lab studies molecular mechanisms of HIV replication and pathogenesis, and their role in mediating pathogen-host interactions, immune responses, and disease outcomes. Using biological, genetic, biochemical, metabolomic, systems biology, and computational approaches, current projects include studies in several areas of virology and immunology: 1) HIV replication and pathogenesis in the immune system, gut, liver, and central nervous system; 2) mechanisms and pathways underlying differences in host responses to viral infection, antiretroviral therapy, and aging; 3) role of exosomes in immune cell communication, stress responses, and disease pathophysiology;  4) mechanisms underlying HIV-associated neurological disorders, accelerated aging, and susceptibility to cancer. The lab uses new technologies, bioinformatics, and computational approaches to generate, visualize, analyze, and interpret large data sets, and broad variety of software and R packages for data integration, network and pathway analysis, and modeling.