Alexander Schier, Ph.D.
Professor of Molecular and Cellular Biology
Department of Molecular and Cellular Biology
16 Divinity Avenue, Room 1029
Cambridge, MA 02138
Visit my lab page here.
Sleep and wakefulness
The genetic and cellular mechanisms that control sleep and wake states remain largely elusive. We have established zebrafish as a model system for sleep research. Zebrafish have the basic hallmarks of sleep-like behaviors. Sleeping fish require stronger stimuli than awake fish to initiate movement and sleep deprivation is followed by increased sleep. In addition, the zebrafish brain expresses peptides that have been implicated in human sleep disorders. We are using genetic and pharmacological screens to isolate sleep regulators and use electrophysiological and imaging approaches to dissect sleep circuits.
For a complete listing of publications click here.
Last Update: 11/7/2013