Sam Kunes, Ph.D.
Professor of Molecular and Cellular Biology
Department of Molecular and Cellular Biology
Biolabs, Room 2013
16 Divinity Avenue
Cambridge, MA 02138
The development and functional history of a nervous system is key to understanding how it directs behavior. My laboratory conducts research that falls within the broad confines of this topic, using the fruitfly Drosophila melanogaster as the system of choice. Drosophila offers a unique opportunity to conduct investigations at the interface of development and behavior, to examine how behavior is modulated by functional plasticity, and to illuminate the relationship between genetic control and the evolutionary divergence of behavior.
Current research in the laboratory includes a study of how a signaling protein, Hedgehog, is transported along axons of the developing visual system, a means by which the retina controls the number of target neurons for retinal axons in the brain. We study the converse problem of how contact between photoreceptor axons and their targets in the brain influences the final stages of photoreceptor neuronal differentiation, including the development of synapses. Another investigation in the laboratory asks how visual experience is remembered. The aim of this project is to determine where and how such memories are encoded. Another study looks at how a protein involved in synaptic plasticity is synthesized locally in response to environmental inputs that produce a memory. A long-term goal of our work is to identify genetic differences that underlie behavioral changes associated with speciation, and relate these to developmental and functional differences in the nervous system.
For a complete listing of publications click here.
Last Update: 11/7/2013