PiN Faculty Member - Lisa Goodrich, PhD

Lisa Goodrich, PhD

Professor of Neurobiology

Harvard Medical School
Department of Neurobiology
Goldenson Building, Room 442
220 Longwood Avenue
Boston, MA 02115
Tel: 617-432-2951
Fax: 617-432-2949
Email: lisa_goodrich@hms.harvard.edu
Visit my lab page here.



We study the cellular and molecular mechanisms that govern the assembly of neural circuits, from the differentiation of neurons to the formation and maintenance of axonal connections and ultimately the generation of behavior. Our overarching goal is to understand how essentially generic developmental events are coordinated so that each type of neuron acquires the uniquely specialized properties that underlie mature circuit function. Many of our studies focus on the auditory system, which is poorly understood relative to the other sensory systems, despite the obvious impact of age-related and noise-induced hearing loss on our society. Additional insights come from studies of the retina, where amacrine cells exhibit diverse shapes and patterns of connections that influence how visual information is processed.

Auditory circuit assembly and function: We perceive sound using precisely wired circuits that originate in the cochlea of the inner ear. The primary auditory neurons – the spiral ganglion neurons (SGNs) – exhibit several distinctive features that ensure that sound information is faithfully communicated from the ear to the brain. For instance, each SGN elaborates enormous and unusually rapid synapses that are critical for sound localization. To learn how spiral ganglion neurons acquire these unique properties, we are dissecting the functions of SGN-specific molecules and transcriptional networks and the contribution of peripheral glia and central input to auditory function. By combining next-gen sequencing technology, live imaging, and behavioral analyses with mouse genetics to visualize and access spiral ganglion neurons, we can link cellular and molecular changes in auditory circuits to functional changes in auditory perception.

Neuronal morphogenesis and wiring in the retina: Unlike the cochlea, the eye houses a complex array of neurons that mediate our sense of vision. The varied morphologies and connectivity of amacrine cells in particular modulate the flow of visual information from photoreceptors to ganglion cells via dendrites restricted to the inner plexiform layer. Since this unipolar morphology is critical to amacrine cell function, we are interested in how this morphology is acquired. We have shown that that reliable formation of this unipolar morphology depends on the atypical cadherin Fat3. Ongoing studies will unravel the cellular and molecular events that are mediated by Fat3: what are the activators and effectors of Fat3? What are the cellular events that ensure development of a single apical dendrite? We address these questions using a combination of biochemistry, live imaging, and mouse genetics.



Last Update: 8/8/2016



Publications

For a complete listing of publications click here.

 


 



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