Scott L. Pomeroy, M.D., Ph.D.
Bronson Crothers Professor of Neurology
Chairman, Department of Neurology at Children's Hospital
F.M. Kirby Neurobiology Center
300 Longwood Avenue
Boston, MA 2115
Tel: 617 919-2749
Medulloblastomas are the most common malignant brain tumors of childhood, with 40-50% overall mortality. Using genomic methods, we have found that certain subtypes of medulloblastomas arise from cerebellar granule cell progenitors. Using a Ptc +/- mouse model, we discovered that tumors arise through a multistep process, starting with persistent proliferation of pre-neoplastic cells followed by emergence of neoplastic cells that progress to form tumors. We now are testing how epigenetic mechanisms promote neoplastic transformation and tumor progression.
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Last Update: 11/7/2013