Scott L. Pomeroy, M.D., Ph.D.

 

Bronson Crothers Professor of Neurology
Chairman, Department of Neurology at Children's Hospital

Boston Children's Hospital
F.M. Kirby Neurobiology Center
Fegan 11
300 Longwood Avenue
Boston, MA 2115
Tel: 617 919-2749
Fax: 617-730-0286
Email: scott.pomeroy@childrens.harvard.edu




Medulloblastomas are the most common malignant brain tumors of childhood, with 40-50% overall mortality. Using genomic methods, we have found that certain subtypes of medulloblastomas arise from cerebellar granule cell progenitors. Using a Ptc +/- mouse model, we discovered that tumors arise through a multistep process, starting with persistent proliferation of pre-neoplastic cells followed by emergence of neoplastic cells that progress to form tumors. We now are testing how epigenetic mechanisms promote neoplastic transformation and tumor progression.


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Last Update: 11/7/2013