Rachelle Gaudet, Ph.D.
Professor of Molecular and Cellular Biology
Department of Molecular & Cell Biology
Northwest Building. Room 302
52 Oxford Street
Cambridge, MA 02138
Visit my lab page here.
We use a combination of x-ray crystallography and other biophysical and biochemical techniques to study the proteins involved in signaling and transport through biological membranes. The main project in the lab is to study the structure and function of “Transient receptor potential” (TRP) channels. The goal is to elucidate the gating mechanism of TRP ion channels involved in temperature sensing and understand modulatory interactions of proteins and small molecules with TRP channels. We focus on the temperature-sensing TRP
channels such as TRPA1, TRPV1, and TRPM8. Several temperature-sensing TRP channels like TRPV1 are expressed in nociceptor neurons, and therefore responsible for pain sensations in response to noxious stimuli. Therefore, with structures of these TRP channels we will be better equipped to design chemical inhibitors, which could potentially be used therapeutically.
Our long-term objective is to see how these TRP channels are gated by temperature and other chemical and physical stimuli at atomic resolution; therefore we prepare crystalline samples of isolated domains and complete channels for x-ray crystallography and structure determination and analysis. We also develop biochemical and biological assays, including electrophysiology, to address questions about TRP channel function.
We have additional projects on TAP, the transporter associated with antigen processing, divalent metal transporters of the NRAMP family, and various cadherins.
For a complete listing of publications click here.
Last Update: 11/7/2013