Susan M. Dymecki, M.D., Ph.D.

 

Professor of Genetics

Harvard Medical School
Deptartment of Genetics
New Research Buildling, Room 358
77 Avenue Louis Pasteur
Boston, MA 02115
Tel: 617-432-7618/ 4812
Fax: 617-432-7595
Email: dymecki@genetics.med.harvard.edu
Visit my lab page here.




The step-by-step differentiation of embryonic cells into different types of neurons lays the foundation for our sensory responses, motor commands, and cognitive behaviors. Our research explores this exquisite differentiation program in mammals using a combination of genetic, embryological, and molecular biological methods. While the generation of such neural diversity is a complex process culminating in the most sophisticated of wiring circuits, one simplifying approach is to start by tracking the specification and differentiation paths taken by specific sets of cells originating from primitive neuroectoderm. Towards this goal, our lab has generated a variety of recombinase-based tools to study progenitor-progeny cell relationships in the mouse. We are applying these and other molecular genetic and genomic tools to study programs underlying the anatomical and functional patterning of neural systems in the brain stem, paying particular attention to development of the precerebellar system (with its central role in movement control and sensorimotor transformations), the serotonergic system (with its involvement in such disparate functions as sleep, arousal, homeostasis, pain, and depression), and the choroid plexus (as an organizing/patterning.


For a complete listing of publications click here.



Last Update: 11/7/2013