PiN Faculty Member - Sandeep Robert Datta, MD, PhD

Sandeep Robert Datta, MD, PhD

Associate Professor of Neurobiology

Harvard Medical School
Department of Neurobiology
Warren Alpert Building, Room 336
220 Longwood Avenue
Boston, MA 02115
Tel: 617-432-7890
Fax: 617-734-7557
Visit my lab page here.

The goal of the Datta laboratory is to address how is the brain extracts information from the environment and converts that information into action.
Animals in the real world have to adapt to changes in sensory cues on timescales of 1s-10s of milliseconds with behavioral responses organized at timescales of 10s-100s of milliseconds. Every time the animal changes its pose or moves its body, its sensory world is reset and has to be sampled anew. From these complex and inter-dependent sensorimotor dynamics arise adaptive patterns of moment-to-moment action that enable animals to interact with the environment in a meaningful manner. Revealing how the brain addresses this challenge requires understanding how neural codes for sensation and action are built, how they interact, and how they are decoded to facilitate the generation of organized and goal-oriented behaviors that evolve coherently over time.
The main hypothesis of the laboratory is that we can gain leverage on this physiological problem by studying neural circuits that underlie stimulus-driven innate behaviors. Given that olfaction is the primary sense used by most animals to communicate with their environment, we focus on characterizing those circuits that enable animals to detect and respond to olfactory cues. Sensory information propagating through this system can drive complex solitary and social behaviors, alter neuroendocrine states and act as unconditioned stimuli to facilitate learning. To understand how information about these sensory cues is translated into action, we study corticostriatal circuits responsible for expressing behavioral components and sequences, and we ask how sensory information modulates the function of these circuits. The motor behaviors elicited by odors both in the real world and in the laboratory are rich in dynamics, and offer a powerful window into how the brain creates adaptive patterns of action.
Although our perspective has been deeply shaped by ethology, we work in the lab and not the field. Therefore, much of our work is about bringing the field to the lab — studying mice in as naturalistic a context as we possibly can — in the belief that understanding the brain requires exploring those purposes for which the brain evolved. We use the entire armamentarium of modern neuroscience techniques, ranging from molecular genetics to machine learning, from large-scale electrophysiology to 3D behavioral imaging. Our work has identified new molecular receptors for ethologically-relevant odors, novel circuits that couple together innate and learned behaviors, organizational principles that govern the organization of sensory information in brain networks, and an underlying syntactical structure to action that is organized on the millisecond timescale, and is explicitly represented by corticostriatial circuits. Current work in the lab focuses on developing closed-loop systems that allow us to manipulate neural activity in response to freely-expressed behaviors, decoding — prying open the circuits that choose which action an animal expresses at any given moment in time, and asking how sensory information percolates into those circuits to influence the global statistics of behavior — and on better understanding how action influences sensation. By using ethology as a lever, we hope to address the fundamental problem of how the brain enables animals to interact with the world.

Last Update: 8/12/2019


For a complete listing of publications click here.



© 2016 President and Fellows
of Harvard College