Gabriel Corfas, Ph.D.
Professor in Neurology and Otolaryngology
Center for Life Science, Rm. 12.256
3 Blackfan Circle
Boston, MA 02115
Visit my lab page here.
Neuron-glia interactions play critical roles in several aspects of nervous system development, including neuronal migration, neuronal and glial differentiation and survival, and the formation and function of synapses. We are primarily interested in understanding the molecular signals that regulate neuron-glia interactions and their roles. To this end, we are using molecular and cellular biological techniques, as well as genetically modified mice.
Part of our work focuses on the growth factor neuregulin (NRG) and its erbB receptors, key mediators of neuron-glia interactions. We have found that these molecules mediate interactions between migrating neurons and the radial glial fibers along which they migrate during the development of the central nervous system, and between several types of glia and neurons in the adult nervous system.
For a complete listing of publications click here.