Immunology Faculty Member - Duane Wesemann, MD, PhD

Duane Wesemann, MD, PhD

Brigham and Women's Hospital
Div. of Rheumatology, Immunology and Allergy
BTM, 60 Fenwood Road, Room 5002O
Boston, MA 02115
Tel: 617-525-1295
Fax: 617-525-1310
Email: dwesemann@bwh.harvard.edu
Visit my lab page here.



A diverse repertoire of immunoglobulins is required to build effective immunity against a vast array of infectious threats. However, expanded immunoglobulin diversity raises the risk of generating antibodies directed against self or otherwise innocuous environmental components, which can lead to autoimmune and allergic disorders, respectively. Our lab studies the process of primary immunoglobulin repertoire diversification and how environmental factors, such as commensal microbes and diet, may influence the structure and depth of this diversity. We are particularly interested in how exposures early in life may shape this process. As we work to identify principles regulating the host:environment interactions that modulate the immune system, we seek to deepen our understanding of how this may impact the development of immunity to infection and efficacy of vaccination. In addition, we are undertaking innovative approaches to uncover therapeutic targets for the treatment of allergic disorders such as food allergies and asthma.






















Last Update: 1/31/2018



Publications

Deployment of Transchromosomal Bovine for Personalized Antimicrobial Therapy. Silver JS, Ashbaugh CD, Miles JJ, Wu H, Marecki GT, Hwang JK, Jiao JA, Abrams M, Sullivan EJ, Wesemann DR. Clin Infect Dis. 2017 Dec 20.

The neonatal window of opportunity – early priming for life. Renz H, Adkins BD, Bartfeld S, Blumberg RS, Farber DL, Garssen J, Ghazal P, Hackam DJ, Marsland BJ, McCoy KD, Penders J, Prinz I, Verhasselt V, von Mutius E, Weiser JN, Wesemann DR, Hornef MW. J Allergy Clin Immunol. 2017 Dec 13.

Stochasticity enables BCR-independent germinal center initiation and antibody affinity maturation. Silver J, Zuo T, Chaudhary N, Kumari R, Tong P, Giguere S, Granato A, Donthula R, Devereaux C, Wesemann DR. J Exp Med. 2018 Jan 2;215(1):77-90.

IgH isotype-specific B cell receptor expression influences B cell fate. Tong P, Granato A, Zou T, Chaudhary N, Zuiani A, Han SS, Donthula R, Shrestha A, Sen D, Magee JM, Gallagher MP, van der Poel CE, Carroll MC, Wesemann DR. PNAS. 2017 Sep 18;114(40):E8411-E8420.

Lactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women. Gosmann C, Anahtar MN, Handley SA, Farcasanu M, Abu-Ali G, Bowman BA, Padavattan N, Desai C, Droit L, Moodley A, Dong M, Chen Y, Ismail N, Ndung’u T, Ghebremichael MS, Wesemann DR, Mitchell C, Dong KL, Huttenhower C, Walker BD, Virgin HW, Kwon DS. Immunity. 2017 Jan 17;46:29-37.

The Microbiome, Timing, and Barrier Function in the Context of Allergic Disease. Wesemann DR, Nagler CR.
Immunity. 2016 Apr 19;44(4):728-38.

Primary immunoglobulin repertoire development: time and space matter. Granato A, Chen Y, Wesemann DR. Curr Opin Immunol. 2015 Apr;33:126-31.

Microbes and B cell development. Wesemann DR. Adv Immunol. 2015;125:155-78.

Molecular Mechanisms of IgE Class Switch Recombination. Tong P, Wesemann DR. Curr Top Microbiol Immunol. 2015;388:21-37

Detection of true IgE-expressing mouse B lineage cells. Gallagher MP, Shrestha A, Magee JM, Wesemann DR. J Vis Exp. 2014 Dec 1;(94)

Early B lineage development occurs in the gut lamina propria and is influenced by commensal microbes. Wesemann DR, Portuguese A, Meyers RM, Gallagher MP, Cluff-Jones K, Magee J, Panchakshari R, Rodig S, Kepler TB, Alt FW. Nature. 2013 Sep 5;501(7465):112-5.

News and Views Reprogramming IgH isotype-switched B cells to functional-grade induced pluripotent stem cells. Wesemann DR, Portuguese AJ, Magee JM, Gallagher MP, Zhou X, Panchakshari RA, Alt FW. Proc Natl Acad Sci U S A.2012 Aug 21;109(34):13745-50.

Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination. Wesemann DR, Magee JM, Boboila C, Calado DP, Gallagher MP, Portuguese AJ, Manis JP, Zhou X, Recher M, Rajewsky K, Notarangelo LD, Alt FW. J Exp Med. 2011 Dec 19;208(13):2733-46.



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