Brigham and Women's Hospital
Department of Medicine
Div. of Rheumatology, Immunology and Allergy
Smith Building 638A
Boston, MA 02115
Visit my lab page here.
A diverse repertoire of immunoglobulins is required to build effective immunity against a vast array of infectious threats. However, expanded immunoglobulin diversity raises the risk of generating antibodies directed against self or otherwise innocuous environmental components, which can lead to autoimmune and allergic disorders, respectively. Our lab studies the process of primary immunoglobulin repertoire diversification and how environmental factors, such as commensal microbes and diet, may influence the structure and depth of this diversity. We are particularly interested in how exposures early in life may shape this process. As we work to identify principles regulating the host:environment interactions that modulate the immune system, we seek to deepen our understanding of how this may impact the development of immunity to infection and efficacy of vaccination. In addition, we are undertaking innovative approaches to uncover therapeutic targets for the treatment of allergic disorders such as food allergies and asthma
Wesemann DR, Portuguese A, Meyers RM, Gallagher MP, Cluff-Jones K, Magee J, Panchakshari R, Rodig S, Kepler TB, Alt FW. 2013. Early B lineage development occurs in the gut lamina propria and is influenced by commensal microbes. Nature. Published online Aug 21; http://dx.doi.org/10.1038/nature12496
Callen E, Di Virgilio M, Kruhlak MJ, Nieto-Soler M, Wong N, Chen HT, Faryabi RB, Polato F, Santos M, Starnes LM, Wesemann DR, Lee JE, Tubbs A, Sleckman BP, Daniel JA, Ge K, Alt FW, Fernandez-Capetillo O, Nussenzweig MC, Nussenzweig A. 2013. 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell. 153(6):1266-80.
Wesemann DR, Portuguese AJ, Magee JM, Gallagher MP, Zhou X, Panchakshari RA, Alt FW. 2012. Reprogramming IgH isotype-switched B cells to functional-grade induced pluripotent stem cells. Proc Natl Acad Sci U S A. 109(34):13745-50.
Wesemann DR, Magee JM, Boboila C, Calado DP, Gallagher MP, Portuguese AJ, Manis JP, Zhou X, Recher M, Rajewsky K, Notarangelo LD, Alt FW. 2011. Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination. J Exp Med. 208(13):2733-46.
Wang JH, Gostissa M, Yan CT, Goff P, Hickernell T, Hansen E, Difilippantonio S, Wesemann DR, Zarrin AA, Rajewsky K, Nussenzweig A, Alt FW. 2009. Mechanisms promoting translocations in editing and switching peripheral B cells. Nature. 460(7252):231-6.
Wesemann DR, Costenbader KH, Coblyn JS. 2009. Co-existing sarcoidosis, systemic lupus erythematosus and the antiphospholipid antibody syndrome: case reports and discussion from the Brigham and Women's Hospital Lupus Center. Lupus. 18(3):202-5.
Wesemann DR, Qin H, Kokorina N, Benveniste EN. Nat Immunol. 2004. TRADD interacts with STAT1-alpha and influences interferon-gamma signaling. 5(2):199-207.
Last Update: 1/6/2014