Immunology Faculty Member - Jatin Vyas, MD, PhD

Jatin Vyas, MD, PhD

MGH, Division of Infectious Disease
55 Fruit Street
GRJ1315
Boston, MA 02115
Tel: 617-643-6444
Fax: 617-643-6443
Email: jvyas@partners.org
Lab Members: 2 post-doctoral fellows, 1 graduate student, and 3 research technicians



Jatin M. Vyas received his PhD in Immunology working in the laboratory of Robert Rich at the Baylor College of Medicine. After completing his MD at Baylor, he performed his internship and medical residency at the Massachusetts General Hospital. He completed his Infectious Disease Fellowship at the MGH/BWH. He did his post-doctoral work in the laboratory of Hidde Ploegh.

Invasive fungal infections are a leading cause of death among immunocompromised patients; thus defining the cellular and molecular mechanisms of host-pathogen interactions is critical for improving outcomes for patients with invasive fungal infections. The Vyas laboratory at the MGH focuses on the host response to pathogenic fungal organisms.  We use fungal pathogens of clinical importance including Cryptococcus neoformans, Aspergillus fumigatus and Candida albicans as the model pathogens to study phagosome formation and maturation. Using live cell imaging with spinning disk confocal microscopy, we visualize cellular responses to fungi in real time. In particular, we examine the role of Dectin-1, LC-3 (member of the autophagy family of proteins), Toll-like receptors, and members of the tetraspanin family during the host fungal immune response.



Last Update: 11/18/2016



Publications

For a complete listing of publications click here.

 


 

Kasperkovitz PV, Cardenas ML, Vyas JM. TLR9 is Actively Recruited to Aspergillus fumigatus Phagosomes and Requires the N-terminal Proteolytic Cleavage Domain for Proper Intracellular Trafficking. 2010. The Journal of Immunology. 185(12):7614-7622. PMCID: In process

Tam JM, Castro CE, Heath RJ, Cardenas ML, Xavier RJ, Lang MJ and
Vyas JM. Control and Manipulation of Pathogens with an Optical Trap for Live Cell Imaging of Intercellular Interactions. 2010. PLoS One. 5(12):e15215. PMCID: PMC3013098

Artavanis-Tsakonas K, Kasperkovitz PV, Papa E, Cardenas ML, Khan NS, Van der Veen AG, Ploegh HL,
Vyas JM. The Tetraspanin CD82 is Specifically Recruited to Fungal and Bacterial Phagosomes Prior to Acidification. 2011. Infection and Immunity. Mar;79(3) 1369-76.

Tam JM, Mansour MK, Khan NS, Yoder NC,
Vyas JM. Use of fungal derived polysaccharide-conjugated particles to probe Dectin-1 responses in innate immunity. 2012. Integrative Biology (Camb). Feb 1;4(2) 220-7.

Mansour MK, Tam JM, Khan NS, Seward M, Davids PJ, Puranam S, Sokolovska A, Sykes DB, Dagher Z, Becker C, Tanne A, Reedy JL, Stuart LM, and
Vyas JM. Dectin-1 activation controls maturation of β-1,3-glucan-containing phagosomes. 2013. Journal of Biological Chemistry. Apr 22. 288(22):16043-54

Tam, J.M., Mansour, M.K., Khan, N.S., Seward, M., Puranam, S., Tanne, A., Sokolovska, A., Becker, C.E., Acharya, M., Baird, M.A., Choi, A.M., Davidson, M.W., Segal, B.H., Lacy-Hulbert, A., Stuart, L.M., Xavier, R.J., and Vyas, J.M. (2014). Dectin-1-dependent LC3 recruitment to phagosomes enhances fungicidal activity in macrophages. J Infect Dis 210, 1844-1854.


Khan NS, Kasperkovitz PV, Timmons AK, Mansour MK, Tam JM, Seward MW, Reedy JL, Puranam S, Feliu M, and Vyas JM (2016). Dectin-1 Controls TLR9 Trafficking to Phagosomes Containing beta-1,3 Glucan. J Immunol. 196(5):2249-61.



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