Immunology Faculty Member - Edda Fiebiger, PhD

Edda Fiebiger, PhD

Boston Children's Hospital
300 Longwood Ave.
Enders Building, #630
Boston, MA 02115
Tel: 617-919-2549
Email: edda.fiebiger@childrens.harvard.edu
Lab Members: 1 Postdoctoral Fellow, 2 Graduate Students, 1 Research Assistant



Antigen presentation is a central event for the initiation of adaptive immune responses. The broad scope of the Fiebiger lab is to study mechanisms of exogenous antigen presentation in the context of gastrointestinal immune responses. Our approach is to complement in vivo studies using transgenic animal models with cell-based in vitro experiments to elucidate the consequences of antigen presentation for intestinal homeostasis and inflammation. Main areas of interest are oral tolerance as well as the pathology of food allergic reactions. Our goal is to understand how inflammatory Th2 responses in the gut are initiated and regulated by dendritic cells and IgE receptors. Additionally, we are studying functions of the IgE protein network beyond the scope of allergic reaction. This topic touches the nascent field of allergo-oncology as well as IgE-mediated immunity in inflammatory bowel disease.



Last Update: 7/16/2014



Publications

Singleton TE, Platzer B, Dehlink E, Fiebiger E. The first transmembrane region of the beta-chain stabilizes the tetrameric FcvarepsilonRI complex. Mol Immunol. 2009;46(11-12):2333-9.

Platzer B, Fiebiger E. The signal peptide of the IgE receptor {alpha}-chain prevents surface expression of an immunoreceptor tyrosine-based activation motif (ITAM)-free receptor pool. J Biol Chem. 2010;14(285):15314-23.

Dehlink E, Platzer B, Baker AH, Larosa J, Pardo M, Dwyer P, Yen EH, Szepfalusi Z, Nurko S, Fiebiger E. A Soluble Form of the High Affinity IgE Receptor, Fc-Epsilon-RI, Circulates in Human Serum. PLoS One. 2011;6(4):e19098.

Wurbel MA, McIntire MG, Dwyer P, Fiebiger E. CCL25/CCR9 interactions regulate large intestinal inflammation in a murine model of acute colitis. PLoS One. 2011;6(1):e16442. PMC3026821

Baker K, Qiao SW, Kuo T, Aveson VG, Platzer B, Andersen JT, Sandlie I, Chen Z, Haar C, Lencer W, Fiebiger E*, Blumberg RA*. FcRn regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells. PNAS, 2011 Jun 14;108(24):9927-32, * Co-senior authors



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