Immunology Faculty Member - Ramnik Xavier, MD

Ramnik Xavier, MD

Broad Institute of MIT and Harvard
7th floor, 415 Main Street

Boston, MA 02114
Tel: 617-643-3331
Fax: 617-643-3328
Email: xavier@molbio.mgh.harvard.edu




The overarching goal of the Xavier lab is to pave the way for better, more targeted therapies for autoimmune and inflammatory diseases. To this end, our interdisciplinary team uses a combination of physiologically relevant cell-based assays, genome editing, novel mouse models, and high-throughput screening technologies. These approaches are used to discover and understand the function of important mediators and effectors involved in innate and adaptive immunity and to determine the role of the microbiome in pathogenesis. Informed by human genetics, we investigate the function of disease-associated genes, using this information to build assays for chemical biology and small molecule screening. Studies in our lab also highlight the significance of the relationship between intracellular responses to microbes and the regulation of adaptive immunity in pathogenesis. We are working toward a full understanding of pathogenesis, which will require a comprehensive grasp of the delicate balance between microbes, immunity, and the human host.

Labs located at Broad Institute and Center for Computational and Integrative Biology at MGH.



Last Update: 8/14/2018



Publications

For a complete listing of publications click here.

 


 

1: Mohanan V, Nakata T, Desch AN, Lévesque C, Boroughs A, Guzman G, Cao Z,
Creasey E, Yao J, Boucher G, Charron G, Bhan AK, Schenone M, Carr SA, Reinecker
HC, Daly MJ, Rioux JD, Lassen KG, Xavier RJ. C1orf106 is a colitis risk gene that
regulates stability of epithelial adherens junctions. Science. 2018 Mar
9;359(6380):1161-1166. doi: 10.1126/science.aan0814. Epub 2018 Feb 1. PubMed
PMID: 29420262; PubMed Central PMCID: PMC6008784.


2: Haber AL, Biton M, Rogel N, Herbst RH, Shekhar K, Smillie C, Burgin G, Delorey
TM, Howitt MR, Katz Y, Tirosh I, Beyaz S, Dionne D, Zhang M, Raychowdhury R,
Garrett WS, Rozenblatt-Rosen O, Shi HN, Yilmaz O, Xavier RJ, Regev A. A
single-cell survey of the small intestinal epithelium. Nature. 2017 Nov
16;551(7680):333-339. doi: 10.1038/nature24489. Epub 2017 Nov 8. PubMed PMID:
29144463.


3: Johannessen L, Sundberg TB, O'Connell DJ, Kolde R, Berstler J, Billings KJ,
Khor B, Seashore-Ludlow B, Fassl A, Russell CN, Latorre IJ, Jiang B, Graham DB,
Perez JR, Sicinski P, Phillips AJ, Schreiber SL, Gray NS, Shamji AF, Xavier RJ.
Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.
Nat Chem Biol. 2017 Oct;13(10):1102-1108. doi: 10.1038/nchembio.2458. Epub 2017
Aug 14. PubMed PMID: 28805801; PubMed Central PMCID: PMC5693369.


4: Wlodarska M, Luo C, Kolde R, d'Hennezel E, Annand JW, Heim CE, Krastel P,
Schmitt EK, Omar AS, Creasey EA, Garner AL, Mohammadi S, O'Connell DJ, Abubucker
S, Arthur TD, Franzosa EA, Huttenhower C, Murphy LO, Haiser HJ, Vlamakis H,
Porter JA, Xavier RJ. Indoleacrylic Acid Produced by Commensal Peptostreptococcus
Species Suppresses Inflammation. Cell Host Microbe. 2017 Jul 12;22(1):25-37.e6.
doi: 10.1016/j.chom.2017.06.007. PubMed PMID: 28704649; PubMed Central PMCID:
PMC5672633.


5: Schirmer M, Smeekens SP, Vlamakis H, Jaeger M, Oosting M, Franzosa EA, Horst
RT, Jansen T, Jacobs L, Bonder MJ, Kurilshikov A, Fu J, Joosten LAB, Zhernakova
A, Huttenhower C, Wijmenga C, Netea MG, Xavier RJ. Linking the Human Gut
Microbiome to Inflammatory Cytokine Production Capacity. Cell. 2016 Dec
15;167(7):1897. doi: 10.1016/j.cell.2016.11.046. PubMed PMID: 27984736.




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of Harvard College