Immunology Faculty Member - Ramnik Xavier, MD

Ramnik Xavier, MD

Massachusetts General Hospital
Center for Computational & Integrative Biology
185 Cambridge Street - Simches 7222
Boston, MA 02114
Tel: 617-643-3331
Fax: 617-643-3328

The overarching goal of the Xavier lab is to pave the way for better, more targeted therapies for autoimmune and inflammatory diseases. To this end, our interdisciplinary team uses a combination of physiologically relevant cell-based assays, genome editing, novel mouse models, and high-throughput screening technologies. These approaches are used to discover and understand the function of important mediators and effectors involved in innate and adaptive immunity and to determine the role of the microbiome in pathogenesis. Informed by human genetics, we investigate the function of disease-associated genes, using this information to build assays for chemical biology and small molecule screening. Studies in our lab also highlight the significance of the relationship between intracellular responses to microbes and the regulation of adaptive immunity in pathogenesis. We are working toward a full understanding of pathogenesis, which will require a comprehensive grasp of the delicate balance between microbes, immunity, and the human host.

Labs located at Broad Institute and Center for Computational and Integrative Biology at MGH.

Last Update: 12/12/2016


For a complete listing of publications click here.



1: Schirmer M, Smeekens SP, Vlamakis H, Jaeger M, Oosting M, Franzosa EA, Jansen
T, Jacobs L, Bonder MJ, Kurilshikov A, Fu J, Joosten LA, Zhernakova A,
Huttenhower C, Wijmenga C, Netea MG, Xavier RJ. Linking the Human Gut Microbiome
to Inflammatory Cytokine Production Capacity. Cell. 2016 Nov
3;167(4):1125-1136.e8. doi: 10.1016/j.cell.2016.10.020. PubMed PMID: 27814509;
PubMed Central PMCID: PMC5131922.
2: Vatanen T, Kostic AD, d'Hennezel E, Siljander H, Franzosa EA, Yassour M, Kolde
R, Vlamakis H, Arthur TD, Hämäläinen AM, Peet A, Tillmann V, Uibo R, Mokurov S,
Dorshakova N, Ilonen J, Virtanen SM, Szabo SJ, Porter JA, Lähdesmäki H,
Huttenhower C, Gevers D, Cullen TW, Knip M; DIABIMMUNE Study Group., Xavier RJ.
Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans.
Cell. 2016 May 5;165(4):842-53. doi: 10.1016/j.cell.2016.04.007. Erratum in:
Cell. 2016 Jun 2;165(6):1551. PubMed PMID: 27133167; PubMed Central PMCID:
3: Lassen KG, McKenzie CI, Mari M, Murano T, Begun J, Baxt LA, Goel G,
Villablanca EJ, Kuo SY, Huang H, Macia L, Bhan AK, Batten M, Daly MJ, Reggiori F,
Mackay CR, Xavier RJ. Genetic Coding Variant in GPR65 Alters Lysosomal pH and
Links Lysosomal Dysfunction with Colitis Risk. Immunity. 2016 Jun
21;44(6):1392-405. doi: 10.1016/j.immuni.2016.05.007. PubMed PMID: 27287411;
PubMed Central PMCID: PMC4936415.
4: Cao Z, Conway KL, Heath RJ, Rush JS, Leshchiner ES, Ramirez-Ortiz ZG, Nedelsky
NB, Huang H, Ng A, Gardet A, Cheng SC, Shamji AF, Rioux JD, Wijmenga C, Netea MG,
Means TK, Daly MJ, Xavier RJ. Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated
Anti-fungal Immunity and Intestinal Inflammation. Immunity. 2015 Oct
20;43(4):715-26. doi: 10.1016/j.immuni.2015.10.005. PubMed PMID: 26488816; PubMed
Central PMCID: PMC4672733.
5: O'Connell DJ, Kolde R, Sooknah M, Graham DB, Sundberg TB, Latorre IJ,
Mikkelsen TS, Xavier RJ. Simultaneous Pathway Activity Inference and Gene
Expression Analysis Using RNA Sequencing. Cell Syst. 2016 May 25;2(5):323-34.
doi: 10.1016/j.cels.2016.04.011. PubMed PMID: 27211859; PubMed Central PMCID:

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of Harvard College