Howard L. Weiner
Harvard Institutes of Medicine
HIM Room 730
77 Avenue Louis Pasteur
Boston, MA 2115
This laboratory's area of research involves studies of autoimmunity in models of experimental allergic encephalomyelitis, arthritis and diabetes in the NOD mouse. We are also investigating immune mechanisms in atherosclerosis, models of Alzheimer's disease and stroke. The primary thrust of investigations is the mechanism by which one can affect these experimental models by mucosally administered antigen and the basic mechanisms underlying these diseases.
Mechanistic studies involve defining mechanisms of tolerance and the cloning and characterization of regulatory T cells involved in tolerance induction including Th3, TR1 and CD25+ regulatory cells.Concomitant studies in humans involve studying immunoregulatory mechanisms in patients with multiple sclerosis.
Weiner, HL Frenkel D. Immunology and immunotherapy in Alzheimer's disease. Nature Rev Immunol. 2006 May; 6:404-16. Review
Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006 May 11;441(7090):235-8.
Ochi H, Abraham M, Ishikawa H, Frenkel D, Yang K, Basso AS, Wu H, Chen ML, Gandhi R, Miller A, Maron R, Weiner HL. Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4(+)CD25(-)LAP(+) T cells. Nat Med. 2006 May 21.
Carrier Y, Yuan J, Kuchroo VK, Weiner HL. Th3 Cells in Peripheral Tolerance. I. Induction of Foxp3-Positive Regulatory T Cells by Th3 Cells Derived from TGF-beta T Cell-Transgenic Mice. J Immunol. 2007 Jan 1;178(1):179-185.
Amit Awasthi1*, Yijun Carrier2*, Jean P. S. Peron, Estelle Bettelli, Vijay K. Kuchroo, Mohamed Oukka1, Howard L. Weiner. IL-27 plays a dominant role in the generation of IL10-producing anti-inflammatory T cells. Nat Immunol in press.
Last Update: 1/6/2014