Shannon J. Turley


Associate Program Head, Graduate Program in Immunology

Dana Farber Cancer Institute
Cancer Imm. & AIDS, Dana 1440A
450 Brookline Ave.
Boston, MA 02115
Tel: 617-632-4990
Fax: 617-582-7999
Email: shannon_turley@dfci.harvard.edu
Visit my lab page here.




The Turley Lab is interested in deciphering how the interactions between antigen presenting cells and CD4 and CD8 T cells can lead to tolerance or immunity. We study molecular and cellular aspects of antigen presentation in diseases such as type-1 diabetes, enteritis, and pancreatic cancer. Combining animal models of disease, multiparameter cytofluorimetry, and high resolution imaging technologies, we explore endocytosis, transport, and/or processing of antigen by multiple lineages of antigen presenting cells including dendritic cells, macrophages, and lymph node stromal cells. The broad goal of our work is to understand how the microenvironments of healthy, inflamed, and malignant tissues influence the biology of these key antigen presenting cells and their interactions with CD4 and CD8 T cells. Ultimately, elucidating the steps leading to primary immune responses against self-antigens should provide the necessary framework for enhancing this process in cancer and dampening it in autoimmune diseases.

References:

Lee JW, Epardaud M, Sun J, Becker JE, Cheng AC, Yonekura A, Heath JK, Turley SJ. 2007. Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self. Nat. Immunol. 8;2: 181-190.

Epardaud M, Rubinstein MP, Yonekura A, Bellemare-Pelletier A, Bronson R, Hamerman JA, Goldrath AW, and Turley SJ
. 2008. IL-15/IL-15Ralpha complexes promote destruction of established tumors by reviving tumor-resident CD8+ T cells. Cancer Res. 68(8):2972-83.

Reynoso ED, Elpek KG, Francisco L, Bronson R, Bellemare-Pelletier A, Sharpe AH, Freeman GJ, and Turley SJ. 2008. Intestinal tolerance is converted to autoimmune enteritis upon PD-1 ligand blockade.
J. Immunol. 182(4):2102-12.

Fletcher AL, Lukacs-Kornek V, Reynoso ED, Pinner SE, Bellemare-Pelletier A, Curry AS, Collier AY, Boyd RL, Turley SJ. 2010. Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady state and inflammatory conditions.
J. Exp. Med. 207(4):689-97. Epub 2010 Mar 22.

Elpek KG, Bellemare-Pelletier A, Malhotra D, Reynoso ED, Lukacs-Kornek V, Turley SJ. 2011. Lymphoid organ-resident dendritic cells exhibit unique transcriptional fingerprints based on subset and site.
PLOS One, 6(8):e23921.

Lukacs-Kornek V, Malhotra D, Fletcher AL, Acton SE, Elpek KG, Tayalia P, Collier A Turley SJ. 2011. Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes.
Nat. Immunol., 12(11):1096-104.

Malhotra D, Fletcher AL, Astarita J, Lukacs-Kornek V, Tayalia P, Gonzalez SF, Elpek KG, Chang SK, Knoblich K, Hemler ME, Brenner M, Carroll MC, Mooney DJ, Immunological Genome Project Consortium, Turley SJ. 2012. Transcriptional profiling of inflamed and steady-state lymph node stroma reveals potential hematopoietic-stromal cross-talk pathways, new conduit components, and the identity of a novel stromal subset.
Nat. Immunol., 13(5):499-510.



Last Update: 1/6/2014