Immunology Faculty Member - Ye Sun, MD, PhD

Ye Sun, MD, PhD

Boston Children's Hospital
Center for Life Sciences Building, Room 18045
300 Longwood Ave.
Boston, MA 02115
Tel: 617-919-2535
Email: ye.sun@childrens.harvard.edu
Visit my lab page here.



Immune cells play important roles in retinal vascular development/remodeling/repair and degeneration. Immune dysregulation during these processes in the eye leads to diseases such as retinopathy of prematurity and age-related macular degeneration. Our research interests focus on the roles of immune-vascular interaction and neuroinflammation in the development of vascular eye disorders and retinal degeneration using genetically modified mouse models and disease models, and developing effective ways to treat or prevent vision loss.
Current research projects in our lab include:

· The mechanisms of immune-vascular crosstalk in controlling retinal angiogenesis.
We aim to investigate the molecular mechanisms of master immune regulator, SOCS3 in immune cells in modulating inflammatory signals to control immune-vascular crosstalk in retinopathy, and target this novel factor to design new therapeutic approaches for treating vascular eye diseases including retinopathy of prematurity and age-related macular degeneration.
· Photoreceptors determination of retinal blood vessel growth in retinopathy through neuroinflammation.
Our recent work leads to the important finding that neuroinflammatory signals in normally avascular photoreceptor layer modulated by transcription factor c-Fos can regulate retinal neovascularization. Our lab focuses on the roles of c-Fos pathway as a major signaling pathway that used by stressed photoreceptors to convey a need for blood vessels and as a potential upstream target to control the development of retinal angiogenesis through neuroinflammation.
· Microglia and immune regulation in photoreceptor development and degeneration.



Last Update: 2/25/2020



Publications

1. Ye Sun, Ann Hellström and Lois Smith. Retinopathy of Prematurity, Book chapter for “the 11th edition of Fanaroff & Martin’s Neonatal-Perinatal Medicine”. Volume II, chapter 96, The eye, 2019.
2. Ye Sun, Lois EH Smith. Retinal vasculature in development and diseases. Annual Review of Vision Science. 2018, 4, 101-122. PMID: 30222533.
3. Ye Sun, Zhiqiang Lin, Chi-Hsiu Liu, Yan Gong, Raffael Liegl, Thomas W. Fredrick, Steven S. Meng, Samuel B. Burnim, Zhongxiao Wang, James D. Akula, William T. Pu, Jing Chen, Lois E.H. Smith. Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos. Journal of Experimental Medicine, 2017, 214 (6), 1753-1767, PMID: 28465464.
4. Ye Sun, Chi-Hsiu Liu, Zhongxiao Wang, Steven S. Meng, Samuel B. Burnim, John Paul SanGiovanni, Theodore M. Kamenecka, Laura A. Solt, Jing Chen. RORa modulates Semaphorin 3E transcription and neurovascular interaction in pathological retinal angiogenesis. FASEB J., 2017,31 (10), 4492-4502. PMID: 28646017.
5. Ye Sun, Raffael Liegl, Yan Gong, Anima Bühler, Bertan Cakir, Steven S. Meng, Samuel B. Burnim, Chi-Hsiu Liu, Tristan Reuer, Peipei Zhang, JohannaM.Walz, Franziska Ludwig, Clemens Lange, Hansjürgen Agostini, Daniel Böhringer, Günther Schlunck, Lois E.H. Smith, Andreas Stahl. Sema3f Protects Against Subretinal Neovascularization In Vivo. EBioMedicine, 2017, 18, 281–287, PMID: 28373097.
6. Ye Sun, Chi-Hsiu Liu, John Paul SanGiovanni, Lucy Evans, Katherine Tian, Bing Zhang, Andreas Stahl, William T Pu, TM Kamenecka, Laura Solt, Jing Chen. Nuclear receptor RORα regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation. Proc. Natl. Acad. Sci., 2015, 112(33), 10401-6. PMID: 26243880.
7. Ye Sun, Meihua Ju, Zhiqiang Lin, Thomas Fredrick, Lucy Evans, Katherine Tian, Nicholas Saba, Peyton Morss, William T Pu, Jing Chen, Andreas Stahl, Jean-Sébastien Joyal, Lois E.H. Smith. SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth. Sci. Signal, 2015, 8(395), ra94. PMID: 26396267 (Cover article).



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