Jack L. Strominger


Dana Farber Cancer Institute
Dana Bldg., Room 1420
44 Binney Street
Boston, MA 2115
Tel: 617-632-3083, 617-495-2733
Fax: 617-632-2662, 496-8351
Email: jlstrom@fas.harvard.edu




The study of histocompatibility in man and in other vertebrates led to the understanding of the mechanisms of immune recognition and to the discovery of novel molecules and cells involved in these processes, including class I and class II proteins encoded in the major histocompatibility complex of all vertebrates examined and T cell receptors. The normal human response to bacterial and viral infection involves these molecules and results in either the generation of T helper cells and antibodies or of cytotoxic T-lymphocytes. In addition, many important human autoimmune diseases are linked to particular alleles of the class I and class II proteins. Tolerance is a central theme. Our studies involve the mechanisms of tolerance, both in pregnancy and in multiple sclerosis or its murine analog, Experimental Acquired Encephalomyelitis.

My laboratory is focused now on 3 main projects:

The role of MHC proteins and of products of other disease susceptibility genes in human autoimmunity, including multiple sclerosis, diabetes, pemphigus vulgaris and ankylosing spondylitis

Activating and inhibitory immunological synapses in human natural killer cells: how they are formed and how they function
Uterine decidual lymphocytes and their roles in the immunobiology of pregnancy. This project involves characterizing uterine natural killer (NK) cells, invariant natural killer T (iNKT) cells and T cells and the roles of these lymphocytes and the many unusual proteins they produce in implantation and maintenance of pregnancy.

References:

Krzewski K and Strominger JLS The Killer's Kiss: The many functions of NK cell Immunological synapses. (2008) Curr Opin Cell Biol. 2008 20:597-605

Zhang, H., Stern, J.N.H. and Strominger, J.L. T cell receptors in an inducible murine IL-10-secreting amino acid copolymer-specific regulatory T cell line that mediates bystander immunosuppression. (2009) PNAS 106:3336-41

Strominger JL. Animal antimicrobial peptides: ancient players in innate immunity. (2009) J Immunol. 182:6633-4.

Li C, Houser BL, Nicotra ML, Strominger JL. HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human decidual macrophages and natural killer cells. (2009) PNAS 106:5767-72.

Krzewski, K, Gil-Krzewska, A, Watts, J, Cooligan, J, Strominger, JL. Both VAMP4 and VAMP7 are indispensable for NK cell cytotoxicity: the requirement for two R-SNARE proteins in granule exocytosis. (2010) J Immunology 184:89.24.

Stern J.N.H., Keskin, D., Kato, Z., Waldner, H., Schallenberg, S., Kuchroo, V., Kretschmer, K., Von Boehmer, H. and Strominger, J.L.Promoting tolerance to proteolipid protein-induced experimental autoimmune encephalomyelitis through dendritic cells. (2010) PNAS.

Houser, B., Hill, J., Tillburgs, T., Nicotra, M., and Strominger, J.L. Two unique human decidual macrophage populations are distinct from those of the M1/M2 paradigm. (2010) J. Immunol. 186(4):2633-42.



Last Update: 1/6/2014