Immunology Faculty Member - Vijay Sankaran, MD, PhD

Vijay Sankaran, MD, PhD

Boston Children's Hospital
CLS Building, Room 03001
3 Blackfan Circle
Boston, MA 02115
Tel: 617-919-6270
Email: sankaran@broadinstitute.org



The overarching goal of the Sankaran lab is to achieve a greater understanding of normal blood cell production (hematopoiesis) and how this process is perturbed in disease. In addition, we are interested in utilizing the insights we obtain into the process of hematopoiesis to develop better and more targeted therapies for a range of diseases affecting the blood system. Our laboratory primarily utilizes studies of human genetic variation across the allelic spectrum, including rare genetic variation leading to blood and immune disorders, as well as common genetic variation that alters blood/ immune cell traits. In addition, we perform functional studies in human hematopoietic cells and in mouse models to gain insights into how hematopoiesis may be altered by genetic variation and how one may intervene to treat genetic blood disorders. We are working toward gaining a comprehensive understanding of how humans produce blood cells in health and how this process is perturbed in disease, as well as how one may intervene for therapy, by utilizing genetic studies.



Last Update: 1/24/2019



Publications

1: Ulirsch JC, Verboon JM, Kazerounian S, Guo MH, Yuan D, Ludwig LS, Handsaker
RE, Abdulhay NJ, Fiorini C, Genovese G, Lim ET, Cheng A, Cummings BB, Chao KR,
Beggs AH, Genetti CA, Sieff CA, Newburger PE, Niewiadomska E, Matysiak M, Vlachos
A, Lipton JM, Atsidaftos E, Glader B, Narla A, Gleizes PE, O'Donohue MF,
Montel-Lehry N, Amor DJ, McCarroll SA, O'Donnell-Luria AH, Gupta N, Gabriel SB,
MacArthur DG, Lander ES, Lek M, Da Costa L, Nathan DG, Korostelev AA, Do R,
Sankaran VG, Gazda HT. The Genetic Landscape of Diamond-Blackfan Anemia. Am J Hum
Genet. 2018 Dec 6;103(6):930-947. doi: 10.1016/j.ajhg.2018.10.027. Epub 2018 Nov
29. PubMed PMID: 30503522.


2: Khajuria RK, Munschauer M, Ulirsch JC, Fiorini C, Ludwig LS, McFarland SK,
Abdulhay NJ, Specht H, Keshishian H, Mani DR, Jovanovic M, Ellis SR, Fulco CP,
Engreitz JM, Schütz S, Lian J, Gripp KW, Weinberg OK, Pinkus GS, Gehrke L, Regev
A, Lander ES, Gazda HT, Lee WY, Panse VG, Carr SA, Sankaran VG. Ribosome Levels
Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis.
Cell. 2018 Mar 22;173(1):90-103.e19. doi: 10.1016/j.cell.2018.02.036. Epub 2018
Mar 15. PubMed PMID: 29551269; PubMed Central PMCID: PMC5866246.


3: Kim AR, Ulirsch JC, Wilmes S, Unal E, Moraga I, Karakukcu M, Yuan D,
Kazerounian S, Abdulhay NJ, King DS, Gupta N, Gabriel SB, Lander ES, Patiroglu T,
Ozcan A, Ozdemir MA, Garcia KC, Piehler J, Gazda HT, Klein DE, Sankaran VG.
Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO
Mutation. Cell. 2017 Mar 9;168(6):1053-1064.e15. doi: 10.1016/j.cell.2017.02.026.
PubMed PMID: 28283061; PubMed Central PMCID: PMC5376096.


4: Guo MH, Nandakumar SK, Ulirsch JC, Zekavat SM, Buenrostro JD, Natarajan P,
Salem RM, Chiarle R, Mitt M, Kals M, Pärn K, Fischer K, Milani L, Mägi R, Palta
P, Gabriel SB, Metspalu A, Lander ES, Kathiresan S, Hirschhorn JN, Esko T,
Sankaran VG. Comprehensive population-based genome sequencing provides insight
into hematopoietic regulatory mechanisms. Proc Natl Acad Sci U S A. 2017 Jan
17;114(3):E327-E336. doi: 10.1073/pnas.1619052114. Epub 2016 Dec 28. PubMed PMID:
28031487; PubMed Central PMCID: PMC5255587.


5: Ulirsch JC, Nandakumar SK, Wang L, Giani FC, Zhang X, Rogov P, Melnikov A,
McDonel P, Do R, Mikkelsen TS, Sankaran VG. Systematic Functional Dissection of
Common Genetic Variation Affecting Red Blood Cell Traits. Cell. 2016 Jun
2;165(6):1530-1545. doi: 10.1016/j.cell.2016.04.048. PubMed PMID: 27259154;
PubMed Central PMCID: PMC4893171.


6: Ludwig LS, Gazda HT, Eng JC, Eichhorn SW, Thiru P, Ghazvinian R, George TI,
Gotlib JR, Beggs AH, Sieff CA, Lodish HF, Lander ES, Sankaran VG. Altered
translation of GATA1 in Diamond-Blackfan anemia. Nat Med. 2014 Jul;20(7):748-53.
doi: 10.1038/nm.3557. Epub 2014 Jun 22. PubMed PMID: 24952648; PubMed Central
PMCID: PMC4087046.



© 2016 President and Fellows
of Harvard College