Immunology Faculty Member - David Sachs, MD

David Sachs, MD

Paul S. Russell/Warner Lambert Professor of Surgery, Emeritus

Massachusetts General Hospital East
Center for Transplantation Sciences, Rm. 5101
149 13th Street
Charlestown, MA 02129
Tel: 617-726-4065
Fax: 617-726-4067

This laboratory is involved in studies of transplantation biology, with an emphasis on understanding and manipulating transplantation immunity and tolerance. Current lines of investigation include:

• Studies on the induction of specific tolerance to both allogeneic and xenogeneic transplants by an approach which utilizes mixed bone marrow chimerism.

• Studies in strains of miniature swine which have been developed as a large animal model for transplantation research. The availability of four different intra-MHC recombinants make this the only large animal model in which immunogenetic studies of the MHC and its role in transplantation can be performed reproducibly. We are presently studying the mechanism (cellular immunity and cytokine gene regulation) by which selective matching of MHC antigens in these animals leads to tolerance following transplantation of vascularized organs. We are also testing strategies for crossing the xenogeneic transplantation barrier swine to primate, with the intent of utilizing our genetically defined swine as donors. 

It is our hope that through understanding the mechanisms involved in transplantation immunity at the basic level we will be able to design new, clinically applicable strategies for the induction of donor specific transplantation tolerance in patients.

Last Update: 3/26/2019


For a complete listing of publications click here.



Yamada K, Yazawa K, Shimizu A, Iwanaga T, Hisashi Y, Nuhn M, O'Malley P, Nobori S, Vagefi PA, Patience C, Fishman J, Cooper DK, Hawley RJ, Greenstein J, Schuurman HJ, Awwad M, Sykes M, Sachs DH. Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. Nat Med 2005; 11: 32-34.
Kawai T, Cosimi BA, Spitzer TR, Tolkoff-Rubn N, Suthanthiran M, Saidman SL, Shaffer J, Preffer FI, Ding R, Sharma V, Fishman JA, Dey BR, Ko DS, Hertl M, Goes NB, Williams WW, Colvin RB, Sykes M, Sachs DH. HLA-Mismatched Renal Transplantation without Maintenance Immunosuppression. N Engl J Med. 2008; 358:353-61. PMCID: PMC3760499.
Nobori S, Shimizu A, Okumi M, Samelson-Jones E, Griesemer A, Hirakata A, Sachs DH, Yamada K. Thymic rejuvenation and the induction of tolerance by adult thymic grafts. Proc Natl Acad Sci U S A. 2006; 103(50):19081-6. PMICD: PMCID: PMC1748180

Weiner J, Scalea J, Ishikawa Y, Okumi M, Griesemer A, Hirakata A, Etter J, Gillon B, Moran S, Shimizu A, Yamada K, Sachs DH. Tolerogenicity of Donor MHC-matched Skin Grafts in Previously Tolerant MGH Miniature Swine. Transplantation. 2012 Dec 27; 94 (12): 1192-9. PMCID: PMC3531825.
Yamada K, Hirakata A, Tchipashvili V, Shimizu A, Iwaki H, Griesemer A, Vallabhajosyula P, Moran S, Sachs DH. Composite islet-kidneys from single baboon donors cure diabetes across fully allogenic barriers. Am J Transplant. 2011 Dec; 11(12): 2603-12. PMCID: PMC3226882.

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