Immunology Faculty Member - Soumya Raychaudhuri, MD, PhD

Soumya Raychaudhuri, MD, PhD

Associate Professor of Medicine, Harvard Medical School
Professor in Genetics, University of Manchester
Associate Member, Broad Institute of Harvard and MIT
Foreign Adjunct Professor in Molecular Medicine, Karolinska Institutet

Harvard Medical School
NRB Building, Room 250, 255
77 Avenue Louis Pasteur
Boston, MA 02115
Tel: 617-525-4484
Fax: 617-525-4488
Email: soumya@broadinstitute.org



The Raychaudhuri Lab focuses on finding and fine-mapping disease alleles and understanding their significance in immune-mediated diseases. Dr. Raychaudhuri has focused on multiple diseases including rheumatoid arthritis, type I diabetes, and tuberculosis infection. He uses human genetics to find disease alleles and genes in large-scale genome-wide human data; he also uses functional genomics and immunoprofiling in CD4+ T cells to understand the functional implications of these genetic alternations. His group has worked extensively on fine-mapping HLA loci, other complex disease loci, devising integrative statistical genetics strategies to identify causal variation by taking advantage of large-scale epigenetic data (for example cell-type and context specific ATAC-seq data), and integrating genetic data with functional genomics and data on human immunological phenotypes.









Last Update: 5/3/2016



Publications

Lenz TL, Deutsch AJ, Han B, Hu X, Okada Y, Eyre S, Knapp M, Zhernakova A, Tom W.J. Huizinga TWJ, Abecasis G, Becker J, Boeckxstaens GE, Chen W-M, Franke A, Gladman DG, Gockel I, Gutierrez-Achury J, Martin J, Nair RP, Nöthen MM, Onengut-Gumuscu S, Rahman P, Rantapää-Dahlqvist S, Stuart PE, Tsoi LC, van Heel DA, Worthington J, Wouters MM, Klareskog L, Elder JT, Gregersen PK, Schumacher J, Rich SS, Wijmenga C, Sunyaev SR, de Bakker PIW, Raychaudhuri S. Widespread non-additive and interaction effects within the HLA modulate the risk of autoimmune diseases. Nature Genetics. 2015 Sep;47(9):1085–90. 

Hu X, Deutsch AJ, Lenz TL, Onengut-Gumuscu S, Han B, Chen W-M, Howson JMM, Todd JA, de Bakker PIW, Rich SS, Raychaudhuri S. Additive and interaction effects at three key amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes genetic risk. Nature Genetics. 2015 Aug;47(8):898–905. 

Hu X, Kim H, Raj T, Brennan PJ, Trynka G, Teslovich N, Slowikowski K, Chen W-M, Onengut S, Baecher-Allan C, de Jager, P, Rich SS, Stranger BE, Brenner MB, Raychaudhuri S. Regulation of gene expression in autoimmune disease loci and the genetic basis of proliferation in CD4+ effector memory T cells. PLoS Genetics. 2014. Jun 26;10(6):e1004404.

Trynka G, Sandor C, Han B, Xu H, Stranger BE, Liu XS, Raychaudhuri S. Chromatin marks identify critical cell types for fine mapping complex trait variants. Nature Genetics. 2012 Dec 23;45(2):124–30. 



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