Immunology Faculty Member - Francisco Quintana, PhD

Francisco Quintana, PhD

Associate Professor of Neurology

Harvard Medical School
77 Ave. Louis Pasteur
HIM Room 718
Boston, MA 02115
Tel: 617-525-5317
Email: fquintana@rics.bwh.harvard.edu



The Quintana laboratory studies the regulation of the immune response by endogenous and environmental factors, with the ultimate goal of dissecting the molecular mechanisms that control the immune response and identifying novel targets for therapeutic immunomodulation in immune-mediated disorders and cancer. To this aim, we use genomic and proteomic tools to analyze in vitro and in vivo experimental models and human samples. A distinctive feature of the Quintana laboratory is that, in addition to human, murine and humanized murine models, our investigations utilize innovative zebrafish systems to study the immune system. We are focused on studying endogenous and environmental factors that regulate the transcriptional and epigenetic programs that control the activity of T cells, dendritic cells and astrocytes which play central roles in the control of the immune response in the periphery and the central nervous system. Collectively, these studies aim to identify basic immunoregulatory mechanisms while guiding the development of new therapeutic approaches for immune-mediated disorders.





Last Update: 1/7/2016



Publications

1. Gandhi R., Kumar D., Burns E.J., Nadeau M., Dake B., Laroni A., Kozoriz D., Weiner H.L. and Quintana F.J. Aryl hydrocarbon receptor activation induces human Tr1-like and Foxp3+ Treg cells.
Nature Immunology 11:846-53 (2010).

2. Yeste, A., Nadeau, M., Burns, E.J., Weiner, H.L., Quintana, F.J. Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis.
Proceedings of the National Academy of Sciences USA 109:11270-5 (2012).

3. Mascanfroni, I.D., Yeste, A., Vieira, S.M., Burns, E.J., Patel, B., Sloma, I., Wu, Y., Mayo, L., Efroni, S., Kuchroo, V.K., Robson, S.C. and Quintana, F.J. IL-27 acts on dendritic cells to suppress the T-cell response and autoimmunity by inducing ENTPD1 (CD39) expression.
Nature Immunology 14:1054-63 (2013).

4. Yeste, A., Mascanfroni, I.D., Nadeau, M., Burns, E.J., Tukpah, A.M., Santiago, A., Wu, C., Patel, B., Kumar, D., Quintana, F.J. IL-21 induces STAT3-mediated CD4+ T-cell production of IL-22.
Nature Communications 6:3753 (2014).

5. Mayo L, Trauger SA, Blain M, Nadeau M, Patel B, Alvarez JI, Mascanfroni ID, Yeste A, Kivisäkk P, Kallas K, Ellezam B, Bakshi R, Prat A, Antel JP, Weiner HL, Quintana F.J. Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation.
Nature Medicine 20:1147-56 (2014).

6. Mascanfroni ID, Takenaka MC., Yeste A, Patel B, Wu Y, Kenison J, Siddiqui S, Basso AS, Otterbein LE, Pardoll DM, Pan F, Priel A, Clish CB, Robson SC, Quintana F.J. Metabolic control of type 1 regulatory (Tr1) cell differentiation by AHR and HIF1-α.
Nature Medicine 21:638-46 (2015).

7. Farez MF, Mascanfroni ID, Mendez-Huergo SP, Yeste A, Gopal M, Garro L, Balbuena Aguirre ME, Patel B, Ysrraelit MC, Zhu C, Kuchroo VK, Rabinovich GA, Quintana F.J.* Correale J*. Melatonin Contributes To The Seasonality Of Multiple Sclerosis Relapses.
Cell 162:1338-52 (2015). *co-senior authors. Corresponding author.




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