Mikael J. Pittet
The laboratory performs a research program on the host immune response in vivo with the main goal to understand the biology of immune cells during inflammation most notably cancer. We use various modalities, including in vivo imaging, to study where, when and how immune cells are produced, traffic, and mediate regulatory or effector functions.
The studies make use of both genetic mouse models, which allow manipulations and analyses of mechanisms and causality, and human patient material, to address whether the results are anchored in clinical correlates. This dual approach gives opportunities for discovery of the immune response’s contributions to tumor progression, new biomarkers useful for diagnosis and prognosis, and novel targets for therapeutic intervention.
We collaborate with several immunology programs at Harvard Medical School, Massachusetts General Hospital and Massachusetts Institute of Technology.
Cortez-Retamozo V, Etzrodt M, Newton A, Ryan R, Pucci F, Sio SW, Kuswanto W, Rauch PJ, Chudnovskiy A, Iwamoto Y, Kohler R, Marinelli B, Gorbatov R, Wojtkiewicz G, Panizzi P, Mino-Kenudson M, Forghani R, Figueiredo JL, Chen JW, Xavier R, Swirski FK, Nahrendorf M, Weissleder R, Pittet MJ. Angiotensin II drives the production of tumor-promoting macrophages. Immunity. 2013;38:296. PMID: 23333075
Etzrodt M, Cortez-Retamozo V, Newton A, Zhao J, Ng A, Wildgruber M, Romero P, Wurdinger T, Xavier R, Geissmann F, Meylan E, Nahrendorf M, Swirski FK, Baltimore D, Weissleder R, Pittet MJ. Regulation of monocyte functional heterogeneity by miR-146a and Relb. Cell Rep. 2012;1:317. PMID: 22545247
Cortez-Retamozo V, Etzrodt M, Newton A, Rauch PJ, Chudnovskiy A, Berger C, Ryan RJ, Iwamoto Y, Marinelli B, Gorbatov R, Forghani R, Novobrantseva TI, Koteliansky V, Figueiredo JL, Chen JW, Anderson DG, Nahrendorf M, Swirski FK, Weissleder R, Pittet MJ. Origins of tumor-associated macrophages and neutrophils. PNAS. 2012;109:2491. PMID: 22308361
Pittet MJ, Weissleder R. Intravital imaging. Cell. 2011;147(5):983. PMID: 22118457
Swirski FK, Nahrendorf M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, Panizzi P, Figueiredo JL, Kohler RH, Chudnovskiy A, Waterman P, Aikawa E, Mempel TR, Libby P, Weissleder R, Pittet MJ. Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science. 2009;325:612. PMID: 19644120
Weissleder R, Pittet MJ. Imaging in the era of molecular oncology. Nature. 2008;452:580. PMID: 18385732
For a complete listing of publications click here.
Last Update: 1/6/2014