Andrew D. Luster
Massachusetts General Hospital
Center for Immunology & Inflammatory Diseases
Division of Rheumatology, Allergy & Immunology
149 13th Street, Rm 8303
Charlestown, MA 02129
Chemokines and Lipid Chemoattractants in Normal Physiology and Disease
Research in my laboratory focuses on understanding the role of chemokines and lipid chemoattractants and their receptors in controlling the trafficking of leukocytes in vivo. Gene-targeted and transgenic reporter mouse strains are developed and used to study the role of chemokines and chemoattractant receptors in the development and delivery of organ-specific innate and adaptive immune and inflammatory responses in mouse models of autoimmune, allergic and infectious diseases to understand how multiple chemoattractant pathways are integrated in vivo for the fine control of leukocyte trafficking. We also study the regulation of chemokine production in vivo since this is a critical determinant of their role in a given biological response. Chemokines and chemoattractant receptors are also interrogated in human diseases, such as asthma and rheumatoid arthritis, to determine chemokine systems relevant for disease pathogenesis. Finally, we have developed a mouse with a human immune system to study mechanistic aspects of the human immune response and human immune cell trafficking in vivo, and to study the interaction of strictly human tropic pathogens (e.g., HIV) with the human immune system.
Mikhak Z, Strassner JP, Luster AD. Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4. J Exp Med. 2013; 210: 1855-1869.
Islam SA, Ling MF, Leung J, Shreffler W, Luster AD. Identification of human CCR8 as a CCL18 receptor. J Exp Med. 2013; in press (Epub ahead of print).
Afshar R, Strassner JP, Seung E, Causton B, Cho JL, Harris RS, Hamilos DL, Medoff BD, Luster AD. Compartmentalized chemokine-dependent regulatory T cell inhibition of allergic pulmonary inflammation. J Allergy Clin Immunol. 2013; 131: 1644-1652.
Bromley SK, Yan S, Tomura M, Kanagawa O, Luster AD. Recirculating memory T cells are a unique subset of CD4+ T cells with a distinct phenotype and migratory pattern. J Immunol. 2013; 190: 970-976.
Groom JR, Richmond J, Murooka TT, Sorensen EW, Sung JH, Bankert K, von Andrian UH, Moon JJ, Mempel TR, Luster AD. CXCR3 receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 differentiation. Immunity 2012; 37:1091-1103.
For a complete listing of publications click here.
Last Update: 1/6/2014