Lester Kobzik


Department of Environmental Health
655 Huntington Avenue
Building 1, Room 507
Boston, MA 02115
Tel: 617-432-2247
Email: lkobzik@hsph.harvard.edu




My main research interest is lung host defense against inhaled challenges be they environmental particulates, pathogens or allergens.
One area of study is how environmental exposures during pregnancy later the susceptibility of newborns to allergic disease (epigenetic ‘prenatal programming’). The other major area is in lung host defense against infections, including mechanisms of enhancing innate immunity through immunomodulators.



Publications

Arredouani, M. S., Palecanda, A., Koziel, H., Huang, Y.-C., Imrich, A., Sulahian, T. H., Ning, Y. Y., et al. (2005). MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages. J. Immunol. 175(9), 6058–6064.

Arredouani, M., Yang, Z., Ning, Y., Qin, G., Soininen, R., Tryggvason, K., & Kobzik, L. (2004). The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles.
J. Exp. Med., 200(2), 267–272. doi:10.1084/jem.20040731.

Lim, R. H., & Kobzik, L. (2009). Maternal transmission of asthma risk.
Am. J. Repro. Immunol. 61(1), 1–10. doi:10.1111/j.1600-0897.2008.00671.x
Fedulov, A. V., & Kobzik, L. (2011). Allergy risk is mediated by dendritic cells with congenital epigenetic changes.
Am. J. Resp. Cell Mol. Biol., 44(3), 285–292. doi:10.1165/rcmb.2009-0400OC.

Ghosh, S., Gregory, D., Smith, A., & Kobzik, L. (2011). MARCO Regulates Early Inflammatory Responses against Influenza: A Useful Macrophage Function with Adverse Outcome.
Am. J. Resp. Cell Mol. Biol., 45(5), 1036. doi:10.1165/rcmb.2010-0349OC.

Zhou, H., Deloid, G., Browning, E., Gregory, D. J., Tan, F., Bedugnis, A. S., Imrich, A., et al. (2012). Genome-Wide RNAi Screen in IFN-γ-Treated Human Macrophages Identifies Genes Mediating Resistance to the Intracellular Pathogen Francisella tularensis.
PLoS ONE, 7(2), e31752. doi:10.1371/journal.pone.0031752.



Last Update: 1/6/2014