Immunology Faculty Member - Shawn Demehri, MD, PhD.

Shawn Demehri, MD, PhD.

Assistant Professor

Department of Dermatology and MGH Cancer Center
Massachusetts General Hospital
Harvard Medical School
Cutaneous Biology Research Center
Building 149 13th Street, 3rd floor
Charlestown MA 02129
Email: sdemehri1@mgh.harvard.edu
Visit my lab page here.



Our laboratory investigates the role of the immune system in modulating the early stages of cancer development in order to harness its anti-tumor properties to combat cancer. To date, several cancer immunotherapeutic drugs have been developed with proven efficacy; however, these drugs are used mainly against late stage cancers to augment the anti-tumor immune response that has already formed against cancer cells. Our research is focused on identifying the immune mechanisms that drive an immune activation sufficient to prevent cancer formation from pre-cancerous lesions. This approach raises a great opportunity to discover novel immune pathways that can be leveraged in cancer therapy and prevention.

To pursue this goal, our laboratory studies the role of alarmins, damage-associated molecular patterns (DAMPs)/stress signals, commensal viruses, and carcinogen and aging associated factors in regulating early cancer development.



Last Update: 11/8/2019



Publications

 

1. Demehri S, Turkoz A, Manivasagam S, Yockey LJ, Turkoz M, Kopan R. Elevated epidermal thymic stromal lymphopoietin levels establish an antitumor environment in the skin. Cancer Cell. 2012 Oct 16;22(4):494-505. PubMed PMID: 23079659.

2. Cunningham TJ, Tabacchi M, Eliane JP, Tuchayi SM, Manivasagam S, Mirzaalian H, Turkoz A, Kopan R, Schaffer A, Saavedra AP, Wallendorf M, Cornelius LA,
Demehri S. Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy. J Clin Invest. 2017 Jan 3;127(1):106-116. PubMed PMID: 27869649.

3. Ameri AH, Moradi Tuchayi S, Zaalberg A, Park JH, Ngo KH, Li T, Lopez E, Colonna M, Lee RT, Mino-Kenudson M,
Demehri S. IL-33/regulatory T cell axis triggers the development of a tumor-promoting immune environment in chronic inflammation. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2646-2651. PubMed PMID: 30696763.

4. Strickley JD, Messerschmidt JL, Awad ME, Li T, Hasegawa T, Ha DT, Nabeta HW, Bevins PA, Ngo KH, Asgari MM, Nazarian RM, Neel VA, Jenson AB, Joh J,
Demehri S. Immunity to commensal papillomaviruses protects against skin cancer. Nature. 2019 Oct 30. PubMed PMID: 31666702.



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