Immunology Faculty Member - Jon Aster, MD, PhD

Jon Aster, MD, PhD

Brigham and Women's Hospital
630G NRB
77 Avenue Louis Pasteur
Boston, MA 02115
Tel: 617-525-4370
Fax: 617-525-4422

The Aster laboratory primarily studies Notch signaling in cancer. Ongoing projects seek to elucidate pathophysiologic mechanisms of Notch activation and downstream signaling; determine Notch targets that mediate the growth and survival of cancer cells; and identify novel Notch pathway agonists and antagonists, with an eye towards cancer therapeutics.

Last Update: 7/16/2014


Gordon WR, Vardar-Ulu D, Histen G, Sanchez-Irizarry C, Aster JC, Blacklow SC.Structural basis for autoinhibition of Notch.Nat Struct Mol Biol. 2007 Apr;14(4):295-300.

Shepard JL, Amatruda JF, Finkelstein D, Ziai J, Finley KR, Stern HM, Chiang K, Hersey C, Barut B, Freeman JL, Lee C, Glickman JN, Kutok JL, Aster JC, Zon LI.A mutation in separase causes genome instability and increased susceptibility to epithelial cancer

Chiang MY, Xu ML, Histen G, Shestova O, Roy M, Nam Y, Blacklow SC, Sacks DB, Pear WS, Aster JC.Identification of a Conserved Negative Regulatory Sequence That Influences the Leukemogenic Activity of NOTCH1.Mol Cell Biol. 2006 Aug;26(16):6261-71.

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