Immunology Faculty Member - Dingding An, PhD

Dingding An, PhD

Boston Children's Hospital
Enders Building, Room 748
300 Longwood Avenue
Boston, MA 02115
Tel: 617-919-2217

Recognition of the important roles the human microbiome plays in health and disease has forcefully blurred the distinction between self and non-self. Remarkably, in the human body, about 90% of cells and 99% of genes are of microbial origin. How the immune system recognizes and reacts to this enormous population of symbiotic microorganisms and how the latter impacts the normal development and homeostasis of the host immune system are two fundamental questions await answers. Dr. An’s research goal is to use a combination of gnotobiotic mice, immunological methods and disease models to tackle these questions and to illuminate new ways of promoting human health. The approach to achieve this goal is to dissect the host-microbe systems into specific temporal and spatial compartments and focus on key events in this relationship. She asks questions not only about “what” and “how” but also about “when” and “where.” In line with these priorities, current projects investigate on 1) how early microbial exposure modulates host immune development and 2) how mucosa-associated microbes direct host homeostasis.

Last Update: 3/31/2015


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