Student Publications

2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000

2016


Beyaz S, Mana MD, Roper J, Kedrin D, Saadatpour S, Hong SJ, Bauer-Rowe KE, Xifaras ME, Akkad A, Pinello L, Katz Y, Shinagare Y, Abu-Remaileh M, Lamming D, Guo G, Selig M, Nielsen GP, Gupta N, Ferrone C, Deshpande V, Yuan GC, Orkin SH, Sabatini DM, Yilmaz OH. High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature 2016, Mar 3; 531(7592):53-8.


Zanoni I1, Tan Y2, Di Gioia M2, Broggi A2, Ruan J3, Shi J4, Donado CA2, Shao F4, Wu H3, Springstead JR5, Kagan JC6. An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells. Science. 2016 Apr 21. pii: aaf3036


SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions. Pucci F, Garris C, Lai CP, Newton A, Pfirschke C, Engblom C, Alvarez D, Sprachman M, Evavold C, Magnuson A, von Andrian UH, Glatz K, Breakefield XO, Mempel TR, Weissleder R, Pittet MJ. Science. 2016 Apr 8;352(6282):242-6. doi: 10.1126/science.aaf1328. Epub 2016 Mar 17.


Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy. Pfirschke C*, Engblom C*, Rickelt S, Cortez-Retamozo V, Garris C, Pucci F, Yamazaki T, Poirier-Colame V, Newton A, Redouane Y, Lin YJ, Wojtkiewicz G, Iwamoto Y, Mino-Kenudson M, Huynh TG, Hynes RO, Freeman GJ, Kroemer G, Zitvogel L, Weissleder R, Pittet MJ. Immunity. 2016 Feb 16;44(2):343-54. doi: 10.1016/j.immuni.2015.11.024. Epub 2016 Feb 9.
*Co-first author


Pucci F, Garris C, Lai CP, Newton A, Pfirschke C, Engblom C, Alvarez D, Sprachman M, Evavold C, Magnuson A, von Andrian UH, Glatz K, Breakefield XO, Mempel TR, Weissleder R, Pittet MJ SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions Science. 2016;352(6282):242-246 - PMID: 26989197


Pfirschke C, Engblom C, Rickelt S, Cortez-Retamozo V, Garris C, Pucci F, Yamasaki T, Poirier-Colame V, Newton A, Redouane Y, Lin YJ, Wojtkiewicz G, Iwamoto Y, Mino-Kenudson M, Huynh TG, Hynes RO, Freeman GJ Kroemer G, Zitvogel L, Weissleder R, Pittet MJ Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy Immunity. 2016;44:1-12 - PMID: 26872698 - PMCID: PMC4758865


Jernej Godec, Yan Tan, Arthur Liberzon, Pablo Tamayo, Atul J. Butte, Jill P. Mesirov, W. Nicholas Haining. A novel compendium of immune signatures identifies both conserved and species-specific biology in the mouse and human response to inflammation. Immunity. 2016 Jan 19;44(1):194-206. (PMID: 26795250)


Yan Tan*, Jernej Godec*, Pablo Tamayo, W. Nicholas Haining, Jill P. Mesirov. A method for downstream analysis of gene set enrichment results facilitates the biological interpretation of vaccine efficacy studies. 2016 bioRxiv doi: 10.1101/043158. *Co-first author.


Panduro M, Benoist C, Mathis D.Tissue Tregs. Annu Rev Immunol. 2016 May 20;34:609-33. doi: 10.1146/annurev-immunol-032712-095948. PMID: 27168246


Kuswanto W, Burzyn D, Panduro M, Wang KK, Jang YC, Wagers AJ, Benoist C, Mathis D. Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells. Immunity. 2016 Feb 16;44(2):355-67. doi: 10.1016/j.immuni.2016.01.009. Epub 2016 Feb 9.


Gene control of tyrosine kinase TIE2 and vascular manifestations of infections. Ghosh CC, David S, Zhang R, Berghelli A, Milam K, Higgins SJ, Hunter J, Mukherjee A, Wei Y, Tran M, Suber F, Kobzik L, Kain KC, Lu S, Santel A, Yano K, Guha P, Dumont DJ, Christiani DC, Parikh SM. Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):2472-7. doi: 10.1073/pnas.1519467113. Epub 2016 Feb 16.


Singhal G, Fisher M, Tan TG, Fattah A, Adams A, Najaria R, Kulkarni R, Benoist C, Flier J, Maratos-Flier E. Fibroblast growth factor 21 (FGF21) protects against high fat diet induced inflammation and islet hyperplasia in pancreas. PLoS One 11(2): e0148252 (2016).


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2015


Das PP, Hendrix DA, Apostolou E, Buchner AH, Canver MC, Beyaz S, Ljuboja D, Kuintzle R, Kim W, Karnik R, Shao Z, Xie H, Xu J, De Los Angeles A, Zhang Y, Choe J, Jun DL, Shen X, Gregory RI, Daley GQ, Meissner A, Kellis M, Hochedlinger K, Kim J, Orkin SH (2015) PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells. Cell Reports. 2015 Sep 1; 12;1-12.


Stable inhibitory activity of regulatory T cells requires the transcription factor Helios.
Kim HJ, Barnitz RA, Kreslavsky T, Brown FD, Moffett H, Lemieux ME, Kaygusuz Y, Meissner T, Holderried TA, Chan S, Kastner P, Haining WN, Cantor H.
Science. 2015 Oct 16;350(6258):334-9. doi: 10.1126/science.aad0616.
PMID:26472910


Fibroblastic reticular cells: organization and regulation of the T lymphocyte life cycle.
Brown FD, Turley SJ.J Immunol. 2015 Feb 15;194(4):1389-94. doi: 10.4049/jimmunol.1402520. Review.
PMID:25663676


Chow, j., Franz, K.M., Kagan, J.C. PRRs are watching you: Localization of innate sensing and signaling regulators.Virology. 2015 May;479-480:104-9. doi: 10.1016/j.virol.2015.02.051.


Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle. Miller MA, Gadde S, Pfirschke C, Engblom C, Sprachman MM, Kohler RH, Yang KS, Laughney AM, Wojtkiewicz G, Kamaly N, Bhonagiri S, Pittet MJ, Farokhzad OC, Weissleder R. Sci Transl Med. 2015 Nov 18;7(314):314ra183. doi: 10.1126/scitranslmed.aac6522.


Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug. Miller MA, Zheng YR, Gadde S, Pfirschke C, Zope H, Engblom C, Kohler RH, Iwamoto Y, Yang KS, Askevold B, Kolishetti N, Pittet M, Lippard SJ, Farokhzad OC, Weissleder R. Nat Commun. 2015 Oct 27;6:8692. doi: 10.1038/ncomms9692.


Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy. Sistigu A, Yamazaki T, Vacchelli E, Chaba K, Enot DP, Adam J, Vitale I, Goubar A, Baracco EE, Remédios C, Fend L, Hannani D, Aymeric L, Ma Y, Niso-Santano M, Kepp O, Schultze JL, Tüting T, Belardelli F, Bracci L, La Sorsa V, Ziccheddu G, Sestili P, Urbani F, Delorenzi M, Lacroix-Triki M, Quidville V, Conforti R, Spano JP, Pusztai L, Poirier-Colame V, Delaloge S, Penault-Llorca F, Ladoire S, Arnould L, Cyrta J, Dessoliers MC, Eggermont A, Bianchi ME, Pittet M, Engblom C, Pfirschke C, Préville X, Uzè G, Schreiber RD, Chow MT, Smyth MJ, Proietti E, André F, Kroemer G, Zitvogel L. Nat Med. 2014 Nov;20(11):1301-9. doi: 10.1038/nm.3708. Epub 2014 Oct 26


Zhang, R., Borges, CM., Fan, M., Harris, JE., Turka, LA. (2015). Requirement for CD28 in effector regulatory T cell differentiation, CCR6 induction, and skin homing. The Journal of Immunology. 195: 4154-4161.


Garris CS, Pittet MJ ER Stress in Dendritic Cells Promotes Cancer.Cell. 2015;161(7):1492-3 - PMID: 26091029


Pfirschke C, Garris C, Pittet MJ Common TLR5 Mutations Control Cancer Progression. Cancer Cell. 2015;27(1):1-3 - PMID: 25584886


Prakash K. Gupta*, Jernej Godec*, David Wolski*, Emily Adland, Kathleen Yates, Cormac Cosgrove, Carola Ledderose, Wolfgang G. Junger, Simon C. Robson, E. John Wherry, Galit Alter, Philip J. R. Goulder, Paul Klenerman, Arlene H. Sharpe, Georg M. Lauer, W. Nicholas Haining. CD39 expression identifies terminally exhausted CD8+ T cells. PLOS Pathogens. 2015 Oct 20;11(10):e1005177. (PMID: 26485519).


Neil Ruparelia, Jernej Godec, Regent Lee, Joshua T. Chai, Erica Dall'Armellina, Debra McAndrew, Janet E. Digby, J. Colin Forfar, Bernard D. Prendergast, Rajesh K Kharbanda, Adrian P. Banning, Stefan Neubauer, Craig A. Lygate, Keith M. Channon, W. Nicholas Haining, Robin P. Choudhury. Acute myocardial infarction activates distinct inflammatory and proliferation pathways in circulating monocytes, prior to recruitment, identified through conserved transcriptional responses in mice and humans. European Heart Journal. 2015 Aug 1;36(29):1923-34. (PMID: 25982896).


Jernej Godec, Glenn S. Cowley, R. Anthony Barnitz, David E. Root, Arlene H. Sharpe, W. Nicholas Haining. Inducible RNAi in vivo reveals that BATF is required to initiate but not to maintain CD8+ T cell effector differentiation. Proceedings of the National Academy of Sciences USA. 2015 Jan 13;112(2):512-7. (PMID: 25548173)


Hwang JK*, Alt FW, Yeap LS*. Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination. Microbiology Spectrum. 2015 Feb;3(1). doi: 10.1128/microbiolspec.MDNA3-0037-2014. *Equal contribution.


Yeap, LS*, Hwang JK*, Du Z, Meyers RM, Meng FL, Jakubauskaite, A, Liu M, Mani V, Neuberg D, Kepler TB, Wang, JH and Alt FW Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes. Cell, 2015, 163 (5): 1124-37. *Equal contribution.


Kohlgruber, A., and Lynch, L. (2015). Adipose tissue inflammation in the pathogenesis of type 2 diabetes. Current Diabetes Reports 15:92. DOI:10.1007/s11892-015-0670-x


K.T.C. Shade, B. Platzer, N. Washburn, V. Mani, Y. Bartsch, M. Conroy, J.D. Pagan, C. Bosques, T.R. Mempel, E. Fiebiger, R. M. Anthony. A Single Glycan on IgE is Indispensable for Initiation of Anaphylaxis. Journal of Experimental Medicine, 2015; DOI: 10.1064/jem.20142182


L.S. Yeap*, J. Hwang*, R.M. Meyers, A. Jakubauskaite, M. Liu, V. Mani, T.B. Kepler, J. Wang, F.W.Alt. Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes. Cell, 2015;163(5):1124- 37. doi: 10.1016/j.cell.2015.10.042.


MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of RORγ⁺ regulatory T cells. Sefik E, Geva-Zatorsky N, Oh S, Konnikova L, Zemmour D, McGuire AM, Burzyn D, Ortiz-Lopez A, Lobera M, Yang J, Ghosh S, Earl A, Snapper SB, Jupp R, Kasper D, Mathis D, Benoist C. Science. 2015 Aug 28;349(6251):993-7. doi: 10.1126/science.aaa9420. Epub 2015 Aug 13.


Meredith M, Zemmour D, Mathis D, Benoist C. Aire controls gene expression in the thymic epithelium with ordered stochasticity. Nat Immunol. 2015 Sep;16(9):942-9. doi: 10.1038/ni.3247. Epub 2015 Aug 3.


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2014


Lee DH, Acharya SS, Kwon M, Drane P, Guan Y, Adelmant G, Kalev P, Shah J, Pellman D, Marto JA, Chowdhury D. Dephosphorylation Enables the Recruitment of 53BP1 to Double-Strand DNA Breaks. Mol Cell. 2014 May 8;54(3):512-25. doi: 10.1016/j.molcel.2014.03.020. Epub 2014 Apr 3. PMID: 24703952 PMCID: PMC4030556


Das PP, Shao Z, Beyaz S, Apostolou E, Pinello Angeles Ade L, O'Brien K, Atsma JM, Fujiwara Y, Nguyen M, Ljuboja D, Guo G, Woo A, Yuan GC, Onder T, Daley G, Hochedlinger K, Kim J, Orkin SH. Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity. Mol Cell. 2014 Jan 9;53(1):32-48. doi: 10.1016/j.molcel.2013.11.011. Epub 2013 Dec 19. PMID: 24361252 PMCID: PMC3919500


Haspot F, Li HW, Lucas CL, Fehr T, Beyaz S, Sykes M. Allospecific rejection of MHC class I-deficient bone marrow by CD8 T cells. Am J Transplant. 2014 Jan;14(1):49-58. doi: 10.1111/ajt.12525. Epub 2013 Dec 4. PMID: 24304495 PMCID: PMC4045013


Bonham KS, Kagan JC. Endosomes as Platforms for NOD-like Receptor Signaling. Cell Host Microbe. 2014 May 14;15(5):523-5. doi: 10.1016/j.chom.2014.05.001. PMID: 24832447


Bonham KS, Orzalli MH, Hayashi K, Wolf AI, Glanemann C, Weninger W, Iwasaki A, Knipe DM, Kagan JC. A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction. Cell. 2014 Feb 13;156(4):705-16. doi: 10.1016/j.cell.2014.01.019. PMID: 24529375 PMCID: PMC3951743


Nunes-Alves C, Booty MG, Carpenter SM, Jayaraman P, Rothchild AC, Behar SM. In search of a new paradigm for protective immunity to TB. Nat Rev Microbiol. 2014 Apr;12(4):289-99. doi: 10.1038/nrmicro3230. Epub 2014 Mar 3. PMID: 24590243


Lymph node fibroblastic reticular cell transplants show robust therapeutic efficacy in high-mortality murine sepsis. Fletcher AL, Elman JS, Astarita J, Murray R, Saeidi N, D'Rozario J, Knoblich K, Brown FD, Schildberg FA, Nieves JM, Heng TS, Boyd RL, Turley SJ, Parekkadan B.
Sci Transl Med. 2014 Aug 13;6(249):249ra109. doi: 10.1126/scitranslmed.3009377.
PMID:25122637


Chang, Jonathan E; Turley, Shannon J. Stromal infrastructure of the lymph node and coordination of immunity. Trends in immunology, 2014, ISSN: 1471-4906


Park SM, Deering RP, Lu Y, Tivnan P, Lianoglou S, Al-Shahrour F, Ebert BL, Hacohen N, Leslie C, Daley GQ, Lengner CJ, Kharas MG. Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs. J Exp Med. 2014 Jan 13;211(1):71-87. doi: 10.1084/jem.20130736. Epub 2014 Jan 6. PMID: 24395885 PMCID: PMC3892968


Bettini ML, Guy C, Dash P, Vignali KM, Hamm DE, Dobbins J, Gagnon E, Thomas PG, Wucherpfennig KW, Vignali DA. Membrane Association of the CD3ε Signaling Domain Is Required for Optimal T Cell Development and Function. J Immunol. 2014 Jul 1;193(1):258-67. doi: 10.4049/jimmunol.1400322. Epub 2014 Jun 4. PMID: 24899501 PMCID: PMC4065803


Birnbaum ME, Mendoza JL, Sethi DK, Dong S, Glanville J, Dobbins J, Ozkan E, Davis MM, Wucherpfennig KW, Garcia KC. Deconstructing the peptide-MHC specificity of T cell recognition. Cell. 2014 May 22;157(5):1073-87. doi: 10.1016/j.cell.2014.03.047. PMID: 24855945 PMCID: PMC4071348


Dwyer DF, Woodruff MC, Carroll MC, Austen KF, Gurish MF. B Cells Regulate CD4+ T Cell Responses to Papain following B Cell Receptor-Independent Papain Uptake. J Immunol. 2014 Jun 13. pii: 1303247. [Epub ahead of print] PMID: 24928991


van Teijlingen NH, Hölzemer A, Körner C, García-Beltrán WF, Schafer JL, Fadda L, Suscovich TJ, Brander C, Carrington M, Evans DT, van Baarle D, Altfeld M. Sequence variations in HIV-1 p24 Gag-derived epitopes can alter binding of KIR2DL2 to HLA-C*03: 04 and modulate primary natural killer cell function. AIDS. 2014 Jun 19;28(10):1399-408. doi: 10.1097/QAD.0000000000000284. PMID: 24785948


Grayson AR, Walsh EM, Cameron MJ, Godec J, Ashworth T, Ambrose JM, Aserlind AB, Wang H, Evan GI, Kluk MJ, Bradner JE, Aster JC, French CA. MYC, a downstream target of BRD-NUT, is necessary and sufficient for the blockade of differentiation in NUT midline carcinoma. Oncogene. 2014 Mar 27;33(13):1736-42. doi: 10.1038/onc.2013.126. Epub 2013 Apr 22. PMID: 23604113 PMCID: PMC3942361 read article


Kurachi M, Barnitz RA, Yosef N, Odorizzi PM, DiIorio MA, Lemieux ME, Yates K, Godec J, Klatt MG, Regev A, Wherry EJ, Haining WN. The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells. Nat Immunol. 2014 Apr;15(4):373-83. doi: 10.1038/ni.2834. Epub 2014 Mar 2. PMID: 24584090 PMCID: PMC4000237


Wang Y, Godec J, Ben-Aissa K, Cui K, Zhao K, Pucsek AB, Lee YK, Weaver CT, Yagi R, Lazarevic V. The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-γ-producing T helper 17 cells. Immunity. 2014 Mar 20;40(3):355-66. doi: 10.1016/j.immuni.2014.01.002. Epub 2014 Feb 13. PMID: 24530058 PMCID: PMC3965587 *Co-first author.


Peter T. Sage, David Alvarez, Jernej Godec, Ulrich von Andrian, Arlene H. Sharpe. Memory-like Properties of Circulating T Follicular Regulatory and Helper Cells. Journal of Clinical Investigation. 2014, 124(12):5191-204. (PMID: 25347469)


Huynh A, Zhang R, Turka LA. Signals and pathways controlling regulatory T cells. Immunol Rev. 2014 Mar;258(1):117-31. doi: 10.1111/imr.12148. PMID: 24517429


Kim J1, Kim JH1, Winau F2.Thinking inside the box: endogenous α-anomeric lipid antigens. Immunity. 2014 Oct 16;41(4):505-6. doi: 10.1016/j.immuni.2014.09.020.


Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JP, Jurczak MJ, Kajimura S, Piston DW, Mathis D, Cinti S, Shulman GI, Seale P, Spiegelman BM. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell. 2014 Jan 16;156(1-2):304-16. doi: 10.1016/j.cell.2013.12.021. PMID: 24439384 PMCID: PMC3922400


Shouval DS, Biswas A, Goettel JA, McCann K, Conaway E, Redhu NS, Mascanfroni ID, Al Adham Z, Lavoie S, Ibourk M, Nguyen DD, Samsom JN, Escher JC, Somech R, Weiss B, Beier R, Conklin LS, Ebens CL, Santos FG, Ferreira AR, Sherlock M, Bhan AK, Müller W, Mora JR, Quintana FJ, Klein C, Muise AM, Horwitz BH, Snapper SB.Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function. Immunity. 2014 May 15;40(5):706-19. doi: 10.1016/j.immuni.2014.03.011. Epub 2014 May 1. PMID: 24792912


Lee MN, Ye C, Villani AC, Raj T, Li W, Eisenhaure TM, Imboywa SH, Chipendo PI, Ran FA, Slowikowski K, Ward LD, Raddassi K, McCabe C, Lee MH, Frohlich IY, Hafler D, Kellis M, Raychaudhuri S, Zhang F, Stranger BE, Benoist CO, De Jager PL, Regev A, Hacohen N . Common genetic variants modulate pathogen-sensing responses in human dendritic cells. Science. 2014 Mar 7;343(6175):1246980. doi: 10.1126/science.1246980. PMID: 24604203


Raj T, Rothamel K, Mostafavi S, Ye C, Lee MN, Replogle JM, Feng T, Lee M, Asinovski N, Frohlich I, Imboywa S, Von Korff A, Okada Y, Patsopoulos NA, Davis S, McCabe C, Paik HI, Srivastava GP, Raychaudhuri S, Hafler DA, Koller D, Regev A, Hacohen N, Mathis D, Benoist C, Stranger BE, De Jager PL. Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes. Science. 2014 May 2;344(6183):519-523. doi: 10.1126/science.1249547. PMID: 24786080


Gu Z, Liu F, Tonkova EA, Lee SY, Tschumperlin DJ, Brenner MB. Soft matrix is a natural stimulator for cellular invasiveness. Mol Biol Cell. 2014 Feb;25(4):457-69. doi: 10.1091/mbc.E13-05-0260. Epub 2013 Dec 11. PMID: 24336521 PMCID: PMC3923638 read article


Lee Y, Collins M, Kuchroo VK. Unexpected targets and triggers of autoimmunity. J Clin Immunol. 2014 Jul;34 Suppl 1:56-60. doi: 10.1007/s10875-014-0040-5. Epub 2014 May 1. PMID: 24789684


Zhu Z, Aref AR, Cohoon TJ, Barbie TU, Imamura Y, Yang S, Moody SE, Shen RR, Schinzel AC, Thai TC, Reibel JB, Tamayo P, Godfrey JT, Qian ZR, Page AN, Maciag K, Chan EM, Silkworth W, Labowsky MT, Rozhansky L, Mesirov JP, Gillanders WE, Ogino S, Hacohen N, Gaudet S, Eck MJ, Engelman JA, Corcoran RB, Wong KK, Hahn WC, Barbie DA. Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit. Cancer Discov. 2014 Apr;4(4):452-65. doi: 10.1158/2159-8290.CD-13-0646. Epub 2014 Jan 20. PMID: 24444711 PMCID: PMC3980023


Savchenko AS, Borissoff JI, Martinod K, De Meyer SF, Gallant M, Erpenbeck L, Brill A, Wang Y, Wagner DD. VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice. Blood. 2014 Jan 2;123(1):141-8. doi: 10.1182/blood-2013-07-514992. Epub 2013 Nov 7. PMID: 24200682 PMCID: PMC3879903


Thomas MP, Whangbo J, McCrossan G, Deutsch AJ, Martinod K, Walch M, Lieberman J. Leukocyte protease binding to nucleic acids promotes nuclear localization and cleavage of nucleic Acid binding proteins. J Immunol. 2014 Jun 1;192(11):5390-7. doi: 10.4049/jimmunol.1303296. Epub 2014 Apr 25. PMID:24771851 PMCID: PMC4041364


Järås M, Miller PG, Chu LP, Puram RV, Fink EC, Schneider RK, Al-Shahrour F, Peña P, Breyfogle LJ, Hartwell KA, McConkey ME, Cowley GS, Root DE, Kharas MG, Mullally A, Ebert BL. Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia. J Exp Med. 2014 Apr 7;211(4):605-12. doi: 10.1084/jem.20131033. Epub 2014 Mar 10. PMID: 24616378


Riol-Blanco L, Ordovas-Montanes J, Perro M, Naval E, Thiriot A, Alvarez D, Paust S, Wood JN, von Andrian UH. Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation. Nature. 2014 Jun 5;510(7503):157-61. doi: 10.1038/nature13199. Epub 2014 Apr 23. PMID: 24759321


Batal I, Azzi J, Mounayar M, Abdoli R, Moore R, Lee JY, Rosetti F, Wang C, Fiorina P, Sackstein R, Ichimura T, Abdi R. The mechanisms of up-regulation of dendritic cell activity by oxidative stress. J Leukoc Biol. 2014 Mar 27. [Epub ahead of print] PMID: 24676276


Rothchild AC, Jayaraman P, Nunes-Alves C, Behar SM. iNKT cell production of GM-CSF controls Mycobacterium tuberculosis. PLoS Pathog. 2014 Jan;10(1):e1003805. doi: 10.1371/journal.ppat.1003805. Epub 2014 Jan 2. PMID: 24391492 PMCID: PMC3879349 read article


Joller N, Lozano E, Burkett PR, Patel B, Xiao S, Zhu C, Xia J, Tan TG, Sefik E, Yajnik V, Sharpe AH, Quintana FJ, Mathis D, Benoist C, Hafler DA, Kuchroo VK. Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity. 2014 Apr 17;40(4):569-81. doi: 10.1016/j.immuni.2014.02.012. PMID: 24745333


Morton AM, Sefik E, Upadhyay R, Weissleder R, Benoist C, Mathis D. Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut. Proc Natl Acad Sci U S A. 2014 May 6;111(18):6696-701. doi: 10.1073/pnas.1405634111. Epub 2014 Apr 21. PMID: 24753589 PMCID: PMC4020091


Joller N, Lozano E, Burkett PR, Patel B, Xiao S, Zhu C, Xia J, Tan TG, Sefik E, Yajnik V, Sharpe AH, Quintana FJ, Mathis D, Benoist C, Hafler DA, Kuchroo VK. Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity. 2014 Apr 17;40(4):569-81. doi: 10.1016/j.immuni.2014.02.012. PMID: 24745333


Yuen GJ, Ausubel FM. Enterococcus infection biology: lessons from invertebrate host models. J Microbiol. 2014 Mar;52(3):200-10. doi: 10.1007/s12275-014-4011-6. Epub 2014 Mar 1. PMID: 24585051


Tan X, Fuchs BB, Wang Y, Chen W, J Yuen G, Chen RB, Jayamani E, Anastassopoulou C, Pukkila-Worley R, Coleman JJ, Mylonakis E. The Role of Candida albicans SPT20 in Filamentation, Biofilm Formation and Pathogenesis. PLoS One. 2014 Apr 14;9(4):e94468. doi: 10.1371/journal.pone.0094468. eCollection 2014. PMID: 24732310 PMCID: PMC3986095 read article


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2013


Chatterjee P, Agyemang AF, Alimzhanov MB, Degn S, Tsiftsoglou SA, Alicot E, Jones SA, Ma M, Carroll MC. Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner. Eur J Immunol. 2013 Jun 10. doi: 10.1002/eji.201343412. [Epub ahead of print] PMID: 23749435


Albacker LA, Chaudhary V, Chang YJ, Kim HY, Chuang YT, Pichavant M, DeKruyff RH, Savage PB, Umetsu DT. Invariant natural killer T cells recognize a fungal glycosphingolipid that can induce airway hyperreactivity. Nat Med. 2013 Oct;19(10):1297-304. doi: 10.1038/nm.3321. Epub 2013 Sep 1. PMID: 23995283


Albacker LA, Yu S, Bedoret D, Lee WL, Umetsu SE, Monahan S, Freeman GJ, Umetsu DT, DeKruyff RH. TIM-4, expressed by medullary macrophages, regulates respiratory tolerance by mediating phagocytosis of antigen-specific T cells. Mucosal Immunol. 2013 May;6(3):580-90. doi: 10.1038/mi.2012.100. Epub 2012 Nov 14. PMID: 23149665


Chaudhary V, Albacker LA, Deng S, Chuang YT, Li Y, Umetsu DT, Savage PB. Synthesis of fungal glycolipid asperamide B and investigation of its ability to stimulate natural killer T cells. Org Lett. 2013 Oct 18;15(20):5242-5. doi: 10.1021/ol4024375. Epub 2013 Oct 10. PMID: 24111801


Guo G, Luc S, Marco E, Lin TW, Peng C, Kerenyi MA, Beyaz S, Kim W, Xu J, Das PP, Neff T, Zou K, Yuan GC, Orkin SH. Mapping cellular hierarchy by single-cell analysis of the cell surface repertoire. Cell Stem Cell. 2013 Oct 3;13(4):492-505. doi: 10.1016/j.stem.2013.07.017. Epub 2013 Sep 12. PMID: 24035353 PMCID: PMC3845089 read article


Chang J, Burkett PR, Borges CM, Kuchroo VK, Turka LA, Chang CH. MyD88 is essential to sustain mTOR activation necessary to promote Th17 cell proliferation by linking IL-1 and IL-23 signaling. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2270-5. doi: 10.1073/pnas.1206048110. Epub 2013 Jan 22. PMID: 23341605 PMCID: PMC3568327 read article


Gat-Viks I, Chevrier N, Wilentzik R, Eisenhaure T, Raychowdhury R, Steuerman Y, Shalek AK, Hacohen N, Amit I, Regev A. Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli. Nat Biotechnol. 2013 Apr;31(4):342-9. doi: 10.1038/nbt.2519. Epub 2013 Mar 17. PMID: 23503680 PMCID: PMC3622156 read article


Tonti E, Jiménez de Oya N, Galliverti G, Moseman EA, Di Lucia P, Amabile A, Sammicheli S, De Giovanni M, Sironi L, Chevrier N, Sitia G, Gennari L, Guidotti LG, von Andrian UH, Iannacone M. Bisphosphonates target B cells to enhance humoral immune responses. Cell Rep. 2013 Oct 31;5(2):323-30. doi: 10.1016/j.celrep.2013.09.004. Epub 2013 Oct 10. PMID: 24120862 PMCID: PMC3838640 read article


Viaud S, Saccheri F, Mignot G, Yamazaki T, Daillère R, Hannani D, Enot DP, Pfirschke C, Engblom C, Pittet MJ, Schlitzer A, Ginhoux F, Apetoh L, Chachaty E, Woerther PL, Eberl G, Bérard M, Ecobichon C, Clermont D, Bizet C, Gaboriau-Routhiau V, Cerf-Bensussan N, Opolon P, Yessaad N, Vivier E, Ryffel B, Elson CO, Doré J, Kroemer G, Lepage P, Boneca IG, Ghiringhelli F, Zitvogel L. The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science. 2013 Nov 22;342(6161):971-6. doi: 10.1126/science.1240537. PMID: 24264990 PMCID: PMC4048947 read article


Cortez-Retamozo V, Engblom C, Pittet MJ. Remote control of macrophage production by cancer. Oncoimmunology. 2013 May 1;2(5):e24183. PMID: 23762799 PMCID: PMC3667905 read article


Garris C, Pittet MJ. Therapeutically re-educating macrophages to treat GBM. Nat Med. 2013 Oct;19(10):1207-8. doi: 10.1038/nm.3355. PMID:24100977


Shim JH, Greenblatt MB, Zou W, Huang Z, Wein MN, Brady N, Hu D, Charron J, Brodkin HR, Petsko GA, Zaller D, Zhai B, Gygi S, Glimcher LH, Jones DC. Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts. J Clin Invest. 2013 Sep 3;123(9):4010-22. doi: 10.1172/JCI69443. Epub 2013 Aug 15. PMID: 23945236. PMCID: PMC3754267


Zou W, Greenblatt MB, Brady N, Lotinun S, Zhai B, de Rivera H, Singh A, Sun J, Gygi SP, Baron R, Glimcher LH, Jones DC. The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2. J Exp Med. 2013 Aug 26;210(9):1793-806. doi: 10.1084/jem.20111790. Epub 2013 Aug 5. PMID: 23918955. PMCID: PMC3754873


Greenblatt MB, Shim JH, Glimcher LH. Mitogen-Activated Protein Kinase Pathways in Osteoblasts. Annu Rev Cell Dev Biol. 2013 May 31. [Epub ahead of print] PMID: 23725048


Greenblatt MB, Aliprantis AO. The immune pathogenesis of scleroderma: context is everything. Curr Rheumatol Rep. 2013 Jan;15(1):297. doi: 10.1007/s11926-012-0297-8. Review. PMID: 23288576. PMCID: PMC3539168


Greenblatt MB, Ritter SY, Wright J, Tsang K, Hu D, Glimcher LH, Aliprantis AO. NFATc1 and NFATc2 repress spontaneous osteoarthritis. Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19914-9. doi: 10.1073/pnas.1320036110. Epub 2013 Nov 18. PMID:24248346. PMCID: PMC3856808


Zhang R, Huynh A, Whitcher G, Chang J, Maltzman JS, Turka LA. An Obligate Cell-Intrinsic Function for CD28 in Regulatory T cells. J Clin Invest. 2013 Feb 1;123(2):580-93. doi: 10.1172/JCI65013. Epub 2013 Jan 2. PMID: 23281398 PMCID: PMC3561819 read article


Huynh A and Turka LA. Control of T cell tolerance by PTEN. Ann N Y Acad Sci. 2013 Mar;1280:27-9. doi: 10.1111/nyas.12015. PMID: 23551099


Burzyn D, Kuswanto W, Kolodin D, Shadrach JL, Cerletti M, Jang Y, Sefik E, Tan TG, Wagers AJ, Benoist C, Mathis D. A special population of regulatory T cells potentiates muscle repair. Cell. 2013 Dec 5;155(6):1282-95. doi: 10.1016/j.cell.2013.10.054. PMID: 24315098 PMCID: PMC3894749


Cortez-Retamozo V, Etzrodt M, Newton A, Ryan R, Pucci F, Sio SW, Kuswanto W, Rauch PJ, Chudnovskiy A, Iwamoto Y, Kohler R, Marinelli B, Gorbatov R, Wojtkiewicz G, Panizzi P, Mino-Kenudson M, Forghani R, Figueiredo JL, Chen JW, Xavier R, Swirski FK, Nahrendorf M, Weissleder R, Pittet MJ. Angiotensin II drives the production of tumor-promoting macrophages. Immunity. 2013 Feb 21;38(2):296-308. doi: 10.1016/j.immuni.2012.10.015. Epub 2013 Jan 17. PMID: 23333075 PMCID: PMC3582771 read article


Burzyn D, Kuswanto W, Kolodin D, Shadrach JL, Cerletti M, Jang Y, Sefik E, Tan TG, Wagers AJ, Benoist C, Mathis D. A special population of regulatory T cells potentiates muscle repair. Cell. 2013 Dec 5;155(6):1282-95. doi: 10.1016/j.cell.2013.10.054. PMID: 24315098 PMCID: PMC3894749


Butovsky O, Jedrychowski MP, Moore CS, Cialic R, Lanser AJ, Gabriely G, Koeglsperger T, Dake B, Wu PM, Doykan CE, Fanek Z, Liu L, Chen Z,Rothstein JD, Ransohoff RM, Gygi SP, Antel JP, Weiner HL. Identification of a unique TGF-β-dependent molecular and functional signature in microglia. Nat Neurosci. 2014 Jan;17(1):131-43. doi: 10.1038/nn.3599. Epub 2013 Dec 8. PMID: 24316888


Yosef N, Shalek AK, Gaublomme JT, Jin H, Lee Y, Awasthi A, Wu C, Karwacz K, Xiao S, Jorgolli M, Gennert D, Satija R, Shakya A, Lu DY, Trombetta JJ, Pillai MR, Ratcliffe PJ, Coleman ML, Bix M, Tantin D, Park H, Kuchroo VK, Regev A. Dynamic regulatory network controlling TH17 cell differentiation. Nature. 2013 Apr 25;496(7446):461-8. doi: 10.1038/nature11981. Epub 2013 Mar 6. PMID: 23467089 PMCID: PMC3637864 read article


Wu C, Pot C, Apetoh L, Thalhamer T, Zhu B, Murugaiyan G, Xiao S, Lee Y, Rangachari M, Yosef N, Kuchroo VK. Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7802-7. doi: 10.1073/pnas.1211776110. Epub 2013 Apr 29. PMID: 23630250 PMCID: PMC3651423 read article


Henrickson SE, Perro M, Loughhead SM, Senman B, Stutte S, Quigley M, Alexe G, Iannacone M, Flynn MP, Omid S, Jesneck JL, Imam S, Mempel TR, Mazo IB, Haining WN, von Andrian UH. Antigen availability determines CD8⁺ T cell-dendritic cell interaction kinetics and memory fate decisions. Immunity. 2013 Sep 19;39(3):496-507. doi: 10.1016/j.immuni.2013.08.034. PMID: 24054328 PMCID: PMC3914670


Malhotra D, Fletcher AL, Turley SJ. Stromal and hematopoietic cells in secondary lymphoid organs: partners in immunity. Immunol Rev. 2013 Jan;251(1):160-76. doi: 10.1111/imr.12023. PMID: 23278748 PMCID: PMC3539229 read article


Mingueneau M, Kreslavsky T, Gray D, Heng T, Cruse R, Ericson J, Bendall S, Spitzer MH, Nolan GP, Kobayashi K, von Boehmer H, Mathis D, Benoist C; Immunological Genome Consortium, Best AJ, Knell J, Goldrath A, Jojic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kim F, Rao TN, Wagers A, Heng T, Ericson J, Rothamel K, Ortiz-Lopez A, Mathis D, Benoist C, Bezman NA, Sun JC, Min-Oo G, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Monach P, Blair DA, Dustin ML, Shinton SA, Hardy RR, Laidlaw D, Collins J, Gazit R, Rossi DJ, Malhotra N, Sylvia K, Kang J, Kreslavsky T, Fletcher A, Elpek K, Bellemare-Pelletier A, Malhotra D, Turley S. The transcriptional landscape of αβ T cell differentiation. Nat Immunol. 2013 Jun;14(6):619-32. doi: 10.1038/ni.2590. Epub 2013 May 5. PMID: 23644507 PMCID: PMC3660436 read article


Jojic V1, Shay T, Sylvia K, Zuk O, Sun X, Kang J, Regev A, Koller D; Immunological Genome Project Consortium, Best AJ, Knell J, Goldrath A, Jojic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kim F, Rao TN, Wagers A, Heng T, Ericson J, Rothamel K, Ortiz-Lopez A, Mathis D, Benoist C, Bezman NA, Sun JC, Min-Oo G, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Monach P, Blair DA, Dustin ML, Shinton SA, Hardy RR, Laidlaw D, Collins J, Gazit R, Rossi DJ, Malhotra N, Sylvia K, Kang J, Kreslavsky T, Fletcher A, Elpek K, Bellemare-Pelletier A, Malhotra D, Turley S. Identification of transcriptional regulators in the mouse immune system. Nat Immunol. 2013 Jun;14(6):633-43. doi: 10.1038/ni.2587. Epub 2013 Apr 28. PMID: 23624555 PMCID: PMC3690947 read article


Fuchs TA, Alvarez JJ, Martinod K, Bhandari AA, Kaufman RM, Wagner DD. Neutrophils release extracellular DNA traps during storage of red blood cell units. Transfusion. 2013 Dec;53(12):3210-6. doi: 10.1111/trf.12203. Epub 2013 Apr 8. PMID: 23560771 PMCID: PMC3728163


Martinod K, Demers M, Fuchs TA, Wong SL, Brill A, Gallant M, Hu J, Wang Y, Wagner DD. Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8674-9. doi: 10.1073/pnas.1301059110. Epub 2013 May 6. PMID: 23650392 PMCID: PMC3666755 read article


Borissoff JI, Joosen IA, Versteylen MO, Brill A, Fuchs TA, Savchenko AS, Gallant M, Martinod K, Ten Cate H, Hofstra L, Crijns HJ, Wagner DD, Kietselaer BL. Elevated levels of circulating DNA and chromatin are independently associated with severe coronary atherosclerosis and a prothrombotic state. Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):2032-40. doi: 10.1161/ATVBAHA.113.301627. Epub 2013 Jul 1. PMID: 3818485 PMCID: PMC3806482


Savchenko AS, Martinod K, Seidman MA, Wong SL, Borissoff JI, Piazza G, Libby P, Goldhaber SZ, Mitchell RN, Wagner DD. Neutrophil extracellular traps form predominantly during the organizing stage of human venous thromboembolism development. J Thromb Haemost. 2014 Jun;12(6):860-70. doi: 10.1111/jth.12571. PMID: 24674135


Martinod K, Wagner DD. Thrombosis: tangled up in NETs. Blood. 2014 May 1;123(18):2768-76. doi: 10.1182/blood-2013-10-463646. Epub 2013 Dec 23. PMID: 24366358 PMCID: PMC4007606


Hartwell KA, Miller PG, Mukherjee S, Kahn AR, Stewart AL, Logan DJ, Negri JM, Duvet M, Järås M, Puram R, Dancik V, Al-Shahrour F, Kindler T, Tothova Z, Chattopadhyay S, Hasaka T, Narayan R, Dai M, Huang C, Shterental S, Chu LP, Haydu JE, Shieh JH, Steensma DP, Munoz B, Bittker JA, Shamji AF, Clemons PA, Tolliday NJ, Carpenter AE, Gilliland DG, Stern AM, Moore MA, Scadden DT, Schreiber SL, Ebert BL, Golub TR. Niche-based screening identifies small-molecule inhibitors of leukemia stem cells. Nat Chem Biol. 2013 Dec;9(12):840-8. doi: 10.1038/nchembio.1367. Epub 2013 Oct 27.PMID: 24161946


Miller PG, Al-Shahrour F, Hartwell KA, Chu LP, Järås M, Puram RV, Puissant A, Callahan KP, Ashton J, McConkey ME, Poveromo LP, Cowley GS, Kharas MG, Labelle M, Shterental S, Fujisaki J, Silberstein L, Alexe G, Al-Hajj MA, Shelton CA, Armstrong SA, Root DE, Scadden DT, Hynes RO, Mukherjee S, Stegmaier K, Jordan CT, Ebert BL. In Vivo RNAi Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling. Cancer Cell. 2013 Jul 8;24(1):45-58. doi: 10.1016/j.ccr.2013.05.004. Epub 2013 Jun 13. PMID: 23770013. PMCID: PMC3746037


Chellappa V, Taylor KN, Pedrick K, Donado C, Netravali IA, Haider K, Cariappa A, Dalomba NF, and Pillai S. M89V sialic acid acetyl esterase and all other non-synonymous common variants of this gene are catalytically normal. PLoS One. 2013;8(1):e53453. doi: 10.1371/journal.pone.0053453. Epub 2013 Jan 7. PMID: 23308225 PMCID: PMC3538537 read article


Wesemann DR, Portuguese AJ, Meyers RM, Gallagher MP, Cluff-Jones K, Magee JM, Panchakshari RA, Rodig SJ, Kepler TB, Alt FW. Microbial colonization influences early B-lineage development in the gut lamina propria. Nature. 2013 Sep 5;501(7465):112-5. doi: 10.1038/nature12496. Epub 2013 Aug 21. PMID: 23965619 PMCID: PMC3807868 read article


Shay T, Jojic V, Zuk O, Rothamel K, Puyraimond-Zemmour D, Feng T, Wakamatsu E, Benoist C, Koller D, Regev A; ImmGen Consortium. Conservation and divergence in the transcriptional programs of the human and mouse immune systems. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2946-51. doi: 10.1073/pnas.1222738110. Epub 2013 Feb 4. PMID: 23382184 PMCID: PMC3581886 read article


Venkatesh D, Ernandez T, Rosetti F, Batal I, Cullere X, Luscinskas FW, Zhang Y, Stavrakis G, García-Cardeña G, Horwitz BH, Mayadas TN. Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-β autocrine signaling to promote monocyte recruitment. Immunity. 2013 May 23;38(5):1025-37. doi: 10.1016/j.immuni.2013.01.012. Epub 2013 Apr 25. PMID: 23623383 PMCID: PMC3760474


Tatituri RV, Watts GF, Bhowruth V, Barton N, Rothchild A, Hsu FF, Almeida CF, Cox LR, Eggeling L, Cardell S, Rossjohn J, Godfrey DI, Behar SM, Besra GS, Brenner MB, Brigl M. Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1827-32. doi: 10.1073/pnas.1220601110. Epub 2013 Jan 10. PMID: 23307809 PMCID: PMC3562825 read article


Burzyn D, Kuswanto W, Kolodin D, Shadrach JL, Cerletti M, Jang Y, Sefik E, Tan TG, Wagers AJ, Benoist C, Mathis D. A special population of regulatory T cells potentiates muscle repair. Cell. 2013 Dec 5;155(6):1282-95. doi: 10.1016/j.cell.2013.10.054. PMID: 24315098 PMCID: PMC3894749


Sitrin J, Ring A, Garcia KC, Benoist C, Mathis D. Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2. J Exp Med. 2013 Jun 3;210(6):1153-65. doi: 10.1084/jem.20122248. Epub 2013 May 6. PMID: 23650440 PMCID: PMC3674700 read article


Burzyn D, Kuswanto W, Kolodin D, Shadrach JL, Cerletti M, Jang Y, Sefik E, Tan TG, Wagers AJ, Benoist C, Mathis D. A special population of regulatory T cells potentiates muscle repair. Cell. 2013 Dec 5;155(6):1282-95. doi: 10.1016/j.cell.2013.10.054. PMID: 24315098 PMCID: PMC3894749


Woodruff MC, Herndon CN, Heesters BA, Carroll MC. Contextual analysis of immunological response through whole-organ fluorescent imaging. Lymphat Res Biol. 2013 Sep;11(3):121-7. doi: 10.1089/lrb.2013.0011. PMID: 24044754 PMCID: PMC3780310


Cezairliyan B, Vinayavekhin N, Grenfell-Lee D, Yuen GJ, Saghatelian A, Ausubel FM. Identification of Pseudomonas aeruginosa phenazines that kill Caenorhabditis elegans. PLoS Pathog. 2013 Jan;9(1):e1003101. doi: 10.1371/journal.ppat.1003101. Epub 2013 Jan 3. PMID: 23300454 PMCID: PMC3536714


top

2012


Detre C, Keszei M, Garrido-Mesa N, Kis-Toth K, Castro W, Agyemang AF, Veerapen N, Besra GS, Carroll MC, Tsokos GC, Wang N, Leadbetter EA, Terhorst C. SAP expression in invariant NKT cells is requisite for cognate help and dispensable for non-cognate support to B cells. Blood. 2012 May 21. [Epub ahead of print] PMID: 22613797


Kim HY, Chang YJ, Subramanian S, Lee HH, Albacker LA, Matangkasombut P, Savage PB, McKenzie AN, Smith DE, Rottman JB, DeKruyff RH, Umetsu DT. Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity. J Allergy Clin Immunol. 2012 Jan;129(1):216-27.e1-6. doi: 10.1016/j.jaci.2011.10.036. Epub 2011 Nov 25. PMID: 22119406 PMCID: PMC3246069 read article


Varadarajan N, Kwon DS, Law KM, Ogunniyi AO, Anahtar MN, Richter JM, Walker BD, Love JC. Rapid, efficient functional characterization and recovery of HIV-specific human CD8+ T cells using microengraving. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3885-90. Epub 2012 Feb 21. PMID:22355106 PMCID: PMC3309713 read article


Astarita JL, Acton SE, Turley SJ. 2012. Podoplanin: emerging functions in development, the immune system, and cancer. Front Immunol. 2012 Sep 12;3:283. doi: 10.3389/fimmu.2012.00283. eCollection 2012. PMID: 22988448 PMCID: PMC3439854 read article


Acton SE*, Astarita JL*, Malhotra D, Lukacs-Kornek V, Franz B, Hess PR, Jakus Z, Kuligowski M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Sceats L, Reynoso ED, Gonzalez SF, Graham DB, Chang J, Peters A, Woodruff M, Kim YA, Swat W, Morita T, Kuchroo V, Carroll MC, Kahn ML, Wucherpfennig KW, Turley SJ. 2012. Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2. Immunity. Immunity. 2012 Aug 24;37(2):276-89. doi: 10.1016/j.immuni.2012.05.022. Epub 2012 Aug 9. PMID 22884313 PMCID: PMC3556784 *co-first authors read article


Malhotra D, Fletcher AL, Astarita J, Lukacs-Kornek V, Tayalia P, Gonzalez SF, Elpek KG, Chang SK, Knoblich K, Hemler ME, Brenner MB, Carroll MC, Mooney DJ, Turley SJ; Immunological Genome Project Consortium. 2012. Nat Immunol. 2012. Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks. Nat Immunol. 2012 Apr 1;13(5):499-510. doi: 10.1038/ni.2262. PMID:22466668 PMCID: PMC3366863 read article


Boboila C, Alt FW, Schwer B. Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks. Adv Immunol. 2012;116:1-49. doi: 10.1016/B978-0-12-394300-2.00001-6. PMID: 23063072


Boboila C, Oksenych V, Gostissa M, Wang JH, Zha S, Zhang Y, Chai H, Lee CS, Jankovic M, Saez LM, Nussenzweig MC, McKinnon PJ, Alt FW, Schwer B. Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1). Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2473-8. doi: 10.1073/pnas.1121470109. Epub 2012 Jan 30. PMID: 22308491 PMCID: PMC3289296 read article


Martin CJ, Booty MG, Rosebrock TR, Nunes-Alves C, Desjardins DM, Keren I, Fortune SM, Remold HG, Behar SM. Efferocytosis is an innate antibacterial mechanism. Cell Host Microbe. 2012 Sep 13;12(3):289-300. doi: 10.1016/j.chom.2012.06.010. PMID: 22980326; PMCID: PMC3517204 read article


Cedeno-Laurent F, Dimitroff CJ. Galectin-1 research in T cell immunity: past, present and future. Clin Immunol. 2012 Feb;142(2):107-16. doi: 10.1016/j.clim.2011.09.011. Epub 2011 Oct 6. PMID: 22019770 PMCID: PMC3266984 read article


Cedeno-Laurent F, Opperman MJ, Barthel SR, Hays D, Schatton T, Zhan Q, He X, Matta KL, Supko JG, Frank MH, Murphy GF, Dimitroff CJ. Metabolic inhibition of galectin-1-binding carbohydrates accentuates antitumor immunity. J Invest Dermatol. 2012 Feb;132(2):410-20. doi: 10.1038/jid.2011.335. Epub 2011 Dec 8. PMID: 22158550 PMCID: PMC3258338  read article


Cedeno-Laurent F, Dimitroff CJ. Galectins and their ligands: negative regulators of anti-tumor immunity. Glycoconj J. 2012 Dec;29(8-9):619-25. doi: 10.1007/s10719-012-9379-0. Epub 2012 Apr 29. PMID: 22544342 PMCID: PMC3410977 read article


Cedeno-Laurent F, Opperman M, Barthel SR, Kuchroo VK, Dimitroff CJ. Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression. J Immunol. 2012 Apr 1;188(7):3127-37. doi: 10.4049/jimmunol.1103433. Epub 2012 Feb 17. PMID: 22345665 PMCID: PMC3311782 read article


Cedeno-Laurent F, Watanabe R, Teague JE, Kupper TS, Clark RA, Dimitroff CJ. Galectin-1 inhibits the viability, proliferation, and Th1 cytokine production of nonmalignant T cells in patients with leukemic cutaneous T-cell lymphoma. Blood. 2012 Apr 12;119(15):3534-8. doi: 10.1182/blood-2011-12-396457. Epub 2012 Mar 1. PMID: 22383798 PMCID: PMC3325040 read article


Cedeno-Laurent F, Dimitroff CJ. Evidence of a novel galectin-9-binding membrane glycoprotein ligand on T helper cells. Clin Immunol. 2012 Apr;143(1):6-7. doi: 10.1016/j.clim.2012.01.010. Epub 2012 Jan 24. PMID: 22321867


Acton SE, Astarita JL, Malhotra D, Lukacs-Kornek V, Franz B, Hess PR, Jakus Z, Kuligowski M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Sceats L,Reynoso ED, Gonzalez SF, Graham DB, Chang J, Peters A, Woodruff M, Kim YA, Swat W, Morita T, Kuchroo V, Carroll MC, Kahn ML, Wucherpfennig KW,Turley SJ. Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2. Immunity. 2012 Aug 24;37(2):276-89. doi: 10.1016/j.immuni.2012.05.022. Epub 2012 Aug 9. PMID: 22884313 PMCID: PMC3556784 read article


Garber M, Yosef N, Goren A, Raychowdhury R, Thielke A, Guttman M, Robinson J, Minie B, Chevrier N, Itzhaki Z, Blecher-Gonen R, Bornstein C, Amann-Zalcenstein D, Weiner A, Friedrich D, Meldrim J, Ram O, Cheng C, Gnirke A, Fisher S, Friedman N, Wong B, Bernstein BE, Nusbaum C, Hacohen N, Regev A, Amit I. A high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals. Mol Cell. 2012 Sep 14;47(5):810-22. doi: 10.1016/j.molcel.2012.07.030. Epub 2012 Aug 30. PMID: 22940246 PMCID: PMC3873101 read article


Moseman EA, Iannacone M, Bosurgi L, Tonti E, Chevrier N, Tumanov A, Fu YX, Hacohen N, von Andrian UH. B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity. Immunity. 2012 Mar 23;36(3):415-26. doi: 10.1016/j.immuni.2012.01.013. Epub 2012 Mar 1. PMID: 22386268 PMCID: PMC3359130 read article


Shalek AK, Gaublomme JT, Wang L, Yosef N, Chevrier N, Andersen MS, Robinson JT, Pochet N, Neuberg D, Gertner RS, Amit I, Brown JR, Hacohen N, Regev A, Wu CJ, Park H. Nanowire-mediated delivery enables functional interrogation of primary immune cells: application to the analysis of chronic lymphocytic leukemia. Nano Lett. 2012 Dec 12;12(12):6498-504. doi: 10.1021/nl3042917. Epub 2012 Dec 3. PMID: 23190424 PMCID: PMC3573729 read article


Narayan K, Sylvia KE, Malhotra N, Yin CC, Martens G, Vallerskog T, Kornfeld H, Xiong N, Cohen NR, Brenner MB, Berg LJ, Kang J; Immunological Genome Project Consortium. Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes. Nat Immunol. 2012 Apr 1;13(5):511-8. doi: 10.1038/ni.2247. PMID: 22473038 PMCID: PMC3427768


Fu W, Ergun A, Lu T, Hill JA, Haxhinasto S, Fassett MS, Gazit R, Adoro S, Glimcher L, Chan S, Kastner P, Rossi D, Collins JJ, Mathis D, Benoist C. A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells.Nat Immunol. 2012 Oct;13(10):972-80. doi: 10.1038/ni.2420. Epub 2012 Sep 9.PMID: 22961053. PMCID: PMC3698954


Fassett MS, Jiang W, D'Alise AM, Mathis D, Benoist C Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3891-6. Epub 2012 Feb 15. PMID: 22345564. PMCID: PMC3309794


Barral DC, Garg S, Casalou C, Watts GF, Sandoval JL, Ramalho JS, Hsu VW, Brenner MB. Arl13b regulates endocytic recycling traffic. Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21354-9. doi 10.1073/pnas.1218272110. Epub 2012 Dec 7. PMID: 23223633. PMCID: PMC3535586


Greenblatt MB, Sargent JL, Farina G, Tsang K, Lafyatis R, Glimcher LH, Whitfield ML, Aliprantis AO. Interspecies Comparison of Human and Murine Scleroderma Reveals IL-13 and CCL2 as Disease Subset-Specific Targets. Am J Pathol. 2012 Mar;180(3):1080-94. Epub 2012 Jan 11. PMID: 22245215. PMCID: PMC3349888


Greenblatt MB, Vbranac V, Tivey T, Tsang K, Tager AM, Aliprantis AO Graft versus Host Disease in the Bone Marrow, Liver and Thymus Humanized Mouse Model.PLoS One. 2012;7(9):e44664. Epub 2012 Sep 5. PMID:22957096. PMCID: PMC3434179


Sung JH, Zhang H, Moseman EA, Alvarez D, Iannacone M, Henrickson SE, de la Torre JC, Groom JR, Luster AD, von Andrian UH. Chemokine guidance of central memory T cells is critical for antiviral recall responses in lymph nodes. Cell. 2012 Sep 14;150(6):1249-63. doi: 10.1016/j.cell.2012.08.015. PMID: 22980984. PMCID: PMC3445043.


Houser BL. Decidual macrophages and their roles at the maternal-fetal interface. Yale J Biol Med. 2012 Mar;85(1):105-18. Epub 2012 Mar 29. PMID: 22461749 PMCID: PMC3313525 read article


Hwang J, Jaroensuk J, Leimanis ML, Russell B, McGready R, Day N, Snounou G, Nosten F, Imwong M. Long-term storage limits PCR-based analyses of malaria parasites in archival dried blood spots. Malar J. 2012 Oct 8;11:339. doi: 10.1186/1475-2875-11-339. PMID: 23043522


Penaranda C, Kuswanto W, Hofmann J, Kenefeck R, Narendran P, Walker LS, Bluestone JA, Abbas AK, Dooms H. IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12668-73. doi: 10.1073/pnas.1203692109. Epub 2012 Jun 25. PMID: 22733744 PMCID: PMC3411948 read article


Butovsky O, Siddiqui S, Gabriely G, Lanser AJ, Dake B, Murugaiyan G, Doykan CE, Wu PM, Gali RR, Iyer LK, Lawson R, Berry J, Krichevsky AM, Cudkowicz ME, Weiner HL. Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS. Journal of Clinical Immunology. J Clin Invest. 2012 Sep 4;122(9):3063-87. doi: 10.1172/JCI62636. Epub 2012 Aug 6. PMID: 22863620 PMCID: PMC3428086 read article


Lee MN, Roy M, Ong SE, Mertins P, Villani AC, Li W, Dotiwala F, Sen J, Doench JG, Orzalli MH, Kramnik I, Knipe DM, Lieberman J, Carr SA, Hacohen N. Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach. Nat Immunol. 2012 Dec 23;14(2):179-85. doi: 10.1038/ni.2509. Epub 2012 Dec 23. PMID: 23263557


Lee Y, Awasthi A, Yosef N, Quintana FJ, Xiao S, Peters A, Wu C, Kleinewietfeld M, Kunder S, Hafler DA, Sobel RA, Regev A, Kuchroo VK. Induction and molecular signature of pathogenic TH17 cells. Nat Immunol. 2012 Oct;13(10):991-9. doi: 10.1038/ni.2416. Epub 2012 Sep 9. PMID: 22961052 PMCID: PMC3459594 read article


León L, Tatituri RV, Grenha R, Sun Y, Barral DC, Minnaard AJ, Bhowruth V, Veerapen N, Besra GS, Kasmar A, Peng W, Moody DB, Grabowski GA, Brenner MB. Saposins utilize two strategies for lipid transfer and CD1 antigen presentation. Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4357-64. doi: 10.1073/pnas.1200764109. Epub 2012 Feb 13. PMID: 22331868 PMCID: PMC3311357 read article


Liu Y, Belkina NV, Park C, Nambiar R, Loughhead SM, Patino-Lopez G, Ben-Aissa K, Hao JJ, Kruhlak MJ, Qi H, von Andrian UH, Kehrl JH, Tyska MJ, Shaw S. Constitutively active ezrin increases membrane tension, slows migration, and impedes endothelial transmigration of lymphocytes in vivo in mice. Blood. 2012 Jan 12;119(2):445-53. doi: 10.1182/blood-2011-07-368860. Epub 2011 Nov 21. PMID: 22106344 PMCID: PMC3257010 read article


Musselwhite LW, Maciag K, Lankowski A, Gretes MC, Wellems TE, Tavera G, Goulding RE, Guillen E. First Universities Allied for Essential Medicines (UAEM) Neglected Diseases and Innovation Symposium. Am J Trop Med Hyg. 2012 Jan;86(1):65-74. doi: 10.4269/ajtmh.2012.11-0608. PMID: 22232453 PMCID: PMC3247111 read article


Malhotra D, Fletcher AL, Astarita J, Lukacs-Kornek V, Tayalia P, Gonzalez SF, Elpek KG, Chang SK, Knoblich K, Hemler ME, Brenner MB, Carroll MC, Mooney DJ, Turley SJ, Immunological Genome Project Consortium. Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks. Nat Immunol. 2012 Apr 1;13(5):499-510. doi: 10.1038/ni.2262. PMID: 22466668 PMCID: PMC3366863 read article


Acton SE, Astarita JL, Malhotra D, Lukacs-Kornek V, Franz B, Hess PR, Jakus Z, Kuligowski M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Sceats L, Reynoso ED, Gonzalez SF, Graham DB, Chang J, Peters A, Woodruff M, Kim YA, Swat W, Morita T, Kuchroo V, Carroll MC, Kahn ML, Wucherpfennig KW, Turley SJ. Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2. Immunity. 2012 Aug 24;37(2):276-89. doi: 10.1016/j.immuni.2012.05.022. Epub 2012 Aug 9. PMID: 22884313 PMCID: PMC3556784 read article


Thomas GM, Carbo C, Curtis BR, Martinod K, Mazo IB, Schatzberg D, Cifuni SM, Fuchs TA, von Andrian UH, Hartwig JH, Aster RH, Wagner DD. Extracellular DNA traps are associated with pathogenesis of TRALI in humans and mice. Blood. 2012 Jun 28;119(26):6335-43. doi: 10.1182/blood-2012-01-405183. Epub 2012 May 17. PMID: 22596262 PMCID: PMC3383196 read article


Brill A, Fuchs TA, Savchenko AS, Thomas GM, Martinod K, De Meyer SF, Bhandari AA, Wagner DD. Neutrophil extracellular traps promote deep vein thrombosis in mice. J Thromb Haemost. 2012 Jan;10(1):136-44. doi: 10.1111/j.1538-7836.2011.04544.x. PMID: 22044575 PMCID: PMC3319651 read article


Demers M, Krause DS, Schatzberg D, Martinod K, Voorhees JR, Fuchs TA, Scadden DT, Wagner DD. Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis. Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13076-81. doi: 10.1073/pnas.1200419109. Epub 2012 Jul 23. PMID: 22826226 PMCID: PMC3420209 read article


Chen K, Nishi H, Travers R, Tsuboi N, Martinod K, Wagner DD, Stan R, Croce K, Mayadas TN. Endocytosis of soluble immune complexes leads to their clearance by FcγRIIIB but induces neutrophil extracellular traps via FcγRIIA in vivo. Blood. 2012 Nov 22;120(22):4421-31. doi: 10.1182/blood-2011-12-401133. Epub 2012 Sep 6. PMID: 22955924 PMCID: PMC3507149 read article


Ashton JM, Balys M, Neering SJ, Hassane DC, Cowley G, Root DE, Miller PG, Ebert BL, McMurray HR, Land H, Jordan CT. Gene sets identified with oncogene cooperativity analysis regulate in vivo growth and survival of leukemia stem cells. Cell Stem Cell. 2012 Sep 7;11(3):359-72. Epub 2012 Aug 2. PMID:22863534; NIHMS: NIHMS572904


Pillai S, Netravali IA, Cariappa A, and Mattoo H. Siglecs and immune regulation. Annu Rev Immunol. 2012;30:357-92. doi: 10.1146/annurev-immunol-020711-075018. Epub 2012 Jan 3. PMID: 22224769 PMCID: PMC3781015 read article


Wesemann DR, Portuguese AJ, Magee JM, Gallagher MP, Zhou X, Panchakshari RA, Alt FW. Reprogramming IgH isotype-switched B cells to functional-grade induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13745-50. doi: 10.1073/pnas.1210286109. Epub 2012 Aug 6. PMID: 22869756 PMCID: PMC3427115  read article


Rosetti F, Tsuboi N, Chen K, Nishi H, Ernandez T, Sethi S, Croce K, Stavrakis G, Alcocer-Varela J, Gómez-Martin D, van Rooijen N, Kyttaris VC, Lichtman AH, Tsokos GC, Mayadas TN. Human lupus serum induces neutrophil-mediated organ damage in mice that is enabled by Mac-1 deficiency J Immunol. 2012 Oct 1;189(7):3714-23. Epub 2012 Aug 29. PMID: 22933624 PMCID: PMC3462585 read article


Crispín JC, Apostolidis SA, Rosetti F, Keszei M, Wang N, Terhorst C, Mayadas TN, Tsokos GC. Cutting edge: protein phosphatase 2A confers susceptibility to autoimmune disease through an IL-17-dependent mechanism. J Immunol. 2012 Apr 15;188(8):3567-71. doi: 10.4049/jimmunol.1200143. Epub 2012 Mar 14. PMID: 22422882 PMCID: PMC3324672 read article


Gohda T, Niewczas MA, Ficociello LH, Walker WH, Skupien J, Rosetti F, Cullere X, Johnson AC, Crabtree G, Smiles AM, Mayadas TN, Warram JH, Krolewski AS. Circulating TNF receptors 1 and 2 predict stage 3 CKD in type 1 diabetes. J Am Soc Nephrol. 2012 Mar;23(3):516-24. doi: 10.1681/ASN.2011060628. Epub 2012 Jan 19. PMID: 22266664 PMCID: PMC3294299 read article


Niewczas MA, Gohda T, Skupien J, Smiles AM, Walker WH, Rosetti F, Cullere X, Eckfeldt JH, Doria A, Mayadas TN, Warram JH, Krolewski AS. Circulating TNF receptors 1 and 2 predict ESRD in type 2 diabetes. J Am Soc Nephrol. 2012 Mar;23(3):507-15. doi: 10.1681/ASN.2011060627. Epub 2012 Jan 19. PMID:22266663 PMCID: PMC3294310 read article


Lee MN, Roy M, Ong SE, Mertins P, Villani AC, Li W, Dotiwala F, Sen J, Doench JG, Orzalli MH, Kramnik I, Knipe DM, Lieberman J, Carr SA, Hacohen N. Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach. Nat Immunol. 2012 Dec 23. doi: 10.1038/ni.2509. [Epub ahead of print] PubMed PMID: 23263557.


Sage, P. T., L. M. Varghese, R. Martinelli, T. E. Sciuto, M. Kamei, A. M. Dvorak, T. A. Springer, A. H. Sharpe, and C. V. Carman. 2012. Antigen Recognition Is Facilitated by Invadosome-like Protrusions Formed by Memory/Effector T Cells. J Immunol 188:3686-3699.


Sage, P. T., L. M. Francisco, C. V. Carman, and A. H. Sharpe. 2012. The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood. Nature immunology.


Acton S, Astarita J, Malhotra D, Lukacs-Kornek V, Franz B, Hess P, Jakus Z, Kuligowski M, Fletcher A, Elpek K, Bellemare-Pelletier A, Sceats L, Reynoso E, Gonzalez S, Graham D, Chang J, Peters A, Woodruff M, Kim Y, Swat W, Morita T, Kuchroo V, Carroll M, Kahn M, Wucherpfennig K, Turley S Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2 Immunity. 2012 Aug 24;37(2):276-89. doi: 10.1016/j.immuni.2012.05.022. Epub 2012 Aug 9. PMID: 22884313 PMCID: PMC3556784 read article


top

2011


Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, Ferraro F, Mercier F, Singh H, Brumme KM, Acharya SS, Scholl C, Tothova Z, Attar E, Frohling S, DePinho RA, Gilliland DG, Armstrong SA, Scadden DT. AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias. Cell. 2011 Sep 2;146(5):697-708. doi: 10.1016/j.cell.2011.07.032. PMID: 21884932 PMCID: PMC3826540 read article


Henrickson SE, Agyemang AF, Garg S, Hafler JP. Integrating clinical perspectives into graduate education. Clin Immunol. 2011 Nov;141(2):228-30PMID: 21944668


Chang YJ, Kim HY, Albacker LA, Baumgarth N, McKenzie ANJ, Smith DE, DeKruyff RH, Umetsu DT (2011) Innate lymphoid cells mediate influenza-induced asthma independent of adaptive immunity. Nat. Immunol. 12(7):631-8. PMID: 21623379 PMCID: PMC3417123


Lucas CL, Workman CJ, Beyaz S, LoCascio S, Zhao G, Vignali DA, Sykes M. LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L. Blood. 2011 May 19;117(20):5532-40. Epub 2011 Mar 21. PubMed PMID: 21422469; PubMed Central PMCID: PMC3109721. read article


Zha S, Guo C, Boboila C, Oksenych V, Cheng HL, Zhang Y, Wesemann DR, Yuen G, Patel H, Goff PH, Dubois RL, Alt FW. ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks. Nature. 2011 Jan 13;469(7329):250-4. Epub 2010 Dec 15. PubMed PMID: 21160472; PubMed Central PMCID: PMC3058373.


Wesemann DR, Magee JM, Boboila C, Calado DP, Gallagher MP, Portuguese AJ, Manis JP, Zhou X, Recher M, Rajewsky K, Notarangelo LD, Alt FW. Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination. J Exp Med. 2011 Dec 19;208(13):2733-46. doi: 10.1084/jem.20111155. Epub 2011 Dec 5. PMID: 22143888 PMCID: PMC3244039 read article


Behar SM, Martin CJ, Booty MG, Nishimura T, Zhao X, Gan HX, Divangahi M, Remold HG. Apoptosis is an innate defense function of macrophages against Mycobacterium tuberculosis. Mucosal Immunol. 2011 May;4(3):279-87. doi: 10.1038/mi.2011.3. Epub 2011 Feb 9. PMID: 21307848; PubMed Central PMCID: PMC3155700.  read article


Paterson AM, Brown KE, Keir ME, Vanguri VK, Riella LV, Chandraker A, Sayegh MH, Blazar BR, Freeman GJ, Sharpe AH. The programmed death-1 ligand 1:b7-1 pathway restrains diabetogenic effector T cells in vivo. J Immunol. 2011 Aug 1;187(3):1097-105. Epub 2011 Jun 22. PubMed PMID: 21697456; PubMed Central PMCID: PMC3148082.


Cale EM, Hraber P, Giorgi EE, Fischer W, Bhattacharya T, Leitner T, Yeh WW, Gleasner C, Green LD, Han CS, Korber B, Letvin NL. Epitope-specific CD8+ T lymphocytes cross-recognize mutant simian immunodeficiency virus (SIV) sequences but fail to contain very early evolution and eventual fixation of epitope escape mutations during SIV infection. J Virol. 2011 Apr;85(8):3746-57. Epub 2011 Feb 9. PMID: 21307185 PMCID: PMC3126128


Hulot SL, Cale EM, Korber BT, Letvin NL. Vaccine-induced CD8+ T lymphocytes of rhesus monkeys recognize variant forms of an HIV epitope but do not mediate optimal functional activity. J Immunol. 2011 May 15;186(10):5663-74. Epub 2011 Apr 13. PubMed PMID: 21490161


Cale EM, Bazick HS, Rianprakaisang TA, Alam SM, Letvin NL. Mutations in a Dominant Nef Epitope of SIVmac Diminish TCR:Epitope Peptide Affinity but not Epitope Peptide:MHC Class I Binding. J Immunol. 2011 Sep 15;187(6):3300-13. doi: 10.4049/jimmunol.1101080. Epub 2011 Aug 12. PMID: 21841125 PMCID: PMC3175636


Barthel SR, Antonopoulos A, Cedeno-Laurent F, Schaffer L, Hernandez G, Patil SA, North SJ, Dell A, Matta KL, Neelamegham S, Haslam SM, Dimitroff CJ. Peracetylated 4-Fluoro-glucosamine Reduces the Content and Repertoire of N- and O-Glycans without Direct Incorporation. J Biol Chem. 2011 Jun 17;286(24):21717-31. Epub 2011 Apr 14. PubMed PMID: 21493714; PubMed Central PMCID: PMC3122228.


Cedeno-Laurent F, Penalva de Oliveira AC, Vidal JE, Trujillo JR. Human Polyomavirus-Associated Cerebral Disorders in the Post-HAART Era. Patholog Res Int. 2011 Feb 22;2011:562427. PubMed PMID: 21437187; PubMed Central PMCID: PMC3062102.


Cedeno-Laurent F, Gómez-Flores M, Mendez N, Ancer-Rodríguez J, Bryant JL,Gaspari AA, Trujillo JR. New insights into HIV-1-primary skin disorders. J Int AIDS Soc. 2011 Jan 24;14:5. Review. PubMed PMID: 21261982; PubMed Central PMCID: PMC3037296.


Chevrier N, Mertins P, Artyomov MN, Shalek AK, Iannacone M, Ciaccio MF, Gat-Viks I, Tonti E, Degrace MM, Clauser KR, Garber M, Eisenhaure TM, Yosef N, Robinson J, Sutton A, Andersen MS, Root DE, von Andrian U, Jones RB, Park H, Carr SA, Regev A, Amit I, Hacohen N. Systematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits. Cell. 2011 Nov 11;147(4):853-67. PubMed PMID: 22078882


Brigl M, Tatituri RV, Watts GF, Bhowruth V, Leadbetter EA, Barton N, Cohen NR, Hsu FF, Besra GS, Brenner MB. Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection. J Exp Med. 2011 Jun 6;208(6):1163-77. Epub 2011 May 9. PMID: 21555485 PMCID:PMC3173255


Cohen NR, Tatituri RV, Rivera A, Watts GF, Kim EY, Chiba A, Fuchs BB, Mylonakis E, Besra GS, Levitz SM, Brigl M, Brenner MB. Innate recognition of cell wall β-glucans drives invariant natural killer T cell responses against fungi. Cell Host Microbe. 2011 Nov 17;10(5):437-50. doi: 10.1016/j.chom.2011.09.011. PMID: 22100160


Cornejo MG, Mabialah V, Sykes SM, Khandan T, Lo Celso C, Lopez C, Rivera-Muñoz P, Rameau P, Tothova Z, Aster JC, Depinho RA, Scadden DT, Gilliland DG, Mercher T. Crosstalk between Notch and AKT signaling during murine megakaryocyte lineage specification. Blood. 2011 Jun 7. [Epub ahead of print] PMID: 21653327 PMCID: PMC3152494


Baecher-Allan CM, Costantino CM, Cvetanovich GL, Ashley CW, Beriou G, Dominguez-Villar M, Hafler DA. CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis. J Immunol. 2011 Mar 15;186(6):3317-26. Epub 2011 Feb 7. PubMed PMID: 21300823.


Dougan M, Li D, Neuberg D, Mihm M, Googe P, Wong KK, Dranoff G. A dual rolefor the immune response in a mouse model of inflammation-associated lung cancer. J Clin Invest. 2011 May 2. pii: 44796. doi: 10.1172/JCI44796. [Epub ahead of print] PMID: 21537082


Garg S, Sharma M, Ung C, Tuli A, Barral DC, Hava DL, Veerapen N, Besra GS, Hacohen N, Brenner MB. Lysosomal trafficking, antigen presentation, and microbial killing are controlled by the Arf-like GTPase Arl8b. Immunity. 2011 Aug 26;35(2):182-93. Epub 2011 Jul 28. PMID: 21802320. PMCID: PMC3584282


Shim JH, Greenblatt MB, Singh A, Brady N, Hu D, Drapp R, Ogawa W, Kasuga M, Noda T, Yang SH, Lee SK, Rebel VI, Glimcher LH. Administration of recombinant BMP2/7 in utero partially reverses Rubinstein Taybi Syndrome-like skeletal defects induced by Pdk1 or Cbp mutations. J Clin Invest. 2012 Jan 3;122(1):91-106. doi: 10.1172/JCI59466. Epub 2011 Dec 1. PMID: 22133875 PMCID: PMC3248303 read article


Dougan SK, Hu CC, Paquet ME, Greenblatt MB, Kim J, Lilley BN, Watson N, Ploegh HL. Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Mol Cell Biol. 2011 Mar;31(6):1145-59. Epub 2011 Jan 10. PMID: 21220515. PMCID: PMC3067910


Zou W, Greenblatt MB, Shim JH, Kant S, Zhai B, Lotinun S, Brady N, Hu DZ, Gygi SP, Baron R, Davis RJ, Jones D, Glimcher LH. MLK3 regulates bone development downstream of the Faciogenital Dysplasia protein FGD1 in mice. J Clin Invest. 2011 Nov;121(11):4383-92. doi: 10.1172/JCI59041. Epub 2011 Oct 3. PMID: 21965325 PMCID: PMC3204846 read article


Henrickson SE, Agyemang AF, Garg S, Hafler JP. Integrating clinical perspectives into graduate education.Clin Immunol. 2011 Nov;141(2):228-30. Epub 2011 Sep 5. No abstract available. PMID:21944668


Houser BL, Tilburgs T, Hill J, Nicotra ML, Strominger JL. (2011). Two unique human decidual macrophage populations. J Immunol. 2011 Feb 15;186(4):2633-42. doi: 10.4049/jimmunol.1003153. Epub 2011 Jan 21. PMID: 21257965 PMCID: PMC3712354 read article


Cipolletta D, Kolodin D, Benoist C, and Mathis D. Tissular Tregs: A unique population of adipose-tissue-resident Foxp3+CD4+ T cells that impacts organismal metabolism. Semin Immunol. 2011 Dec;23(6):431-7. doi: 10.1016/j.smim.2011.06.002. Epub 2011 Jul 2. PMID: 21724410


Lin Y, Zhang L, Cai AX, Lee M, Zhang W, Neuberg D, Canning CM, Soiffer RJ, Alyea EP, Ritz J, Hacohen N, Means TK, Wu CJ. Effective posttransplant antitumor immunity is associated with TLR-stimulating nucleic acid-immunoglobulin complexes in humans. J Clin Invest. 2011. 121(4):1574-84. PMCID: PMC3069775.


Chang SK, Noss EH, Chen M, Gu Z, Townsend K, Grenha R, Leon L, Lee SY, Lee DM, Brenner MB. Cadherin-11 regulates fibroblast inflammation. Proc Natl Acad Sci U S A. 2011 May 17;108(20):8402-7. doi: 10.1073/pnas.1019437108. Epub 2011 May 2. PMID: 21536877 PMCID: PMC3100978 read article


Peters A, Lee Y, Kuchroo VK. The many faces of Th17 cells. Curr Opin Immunol. 2011 Dec;23(6):702-6. doi: 10.1016/j.coi.2011.08.007. Epub 2011 Sep 6. PMID: 21899997; PMCID: PMC3232281 read article


Chang SK, Noss EH, Chen M, Gu Z, Townsend K, Grenha R, Leon L, Lee SY, Lee DM,Brenner MB. Cadherin-11 regulates fibroblast inflammation. Proc Natl Acad Sci U S A. 2011 May 17;108(20):8402-7. Epub 2011 May 2. PubMed PMID: 21536877; PubMed Central PMCID: PMC3100978.


Kasmar AG, van Rhijn I, Cheng TY, Turner M, Seshadri C, Schiefner A, Kalathur RC, Annand JW, de Jong A, Shires J, Leon L, Brenner M, Wilson IA, Altman JD, Moody DB. CD1b tetramers bind αβ T cell receptors to identify a mycobacterial glycolipid-reactive T cell repertoire in humans. J Exp Med. 2011 Aug 29;208(9):1741-7. doi: 10.1084/jem.20110665. Epub 2011 Aug 1. PMID: 21807869 PMCID: PMC3171094 read article


Manne J, Maciag K. Neglected tropical diseases and the HIV prevention agenda. Lancet. 2011 Dec 17;378(9809):2069-70. doi: 10.1016/S0140-6736(11)61897-7. PMID: 22177509


Lukacs-Kornek V, Malhotra D, Fletcher AL, Acton SE, Elpek KG, Tayalia P, Collier AR, Turley SJ. Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes. Nat Immunol. 2011 Sep 18;12(11):1096-104. doi: 10.1038/ni.2112. PMID: 21926986 PMCID: PMC3457791 read article


Elpek KG, Bellemare-Pelletier A, Malhotra D, Reynoso ED, Lukacs-Kornek V, DeKruyff RH, Turley SJ. Lymphoid organ-resident dendritic cells exhibit unique transcriptional fingerprints based on subset and site. PLoS One. 2011;6(8):e23921. doi: 10.1371/journal.pone.0023921. Epub 2011 Aug 19. PMID: 21886840 PMCID: PMC3158776 read article


Fletcher AL, Malhotra D, Acton SE, Lukacs-Kornek V, Bellemare-Pelletier A, Curry M, Armant M, Turley SJ. Reproducible isolation of lymph node stromal cells reveals site-dependent differences in fibroblastic reticular cells. Front Immunol. 2011 Sep 12;2:35. doi: 10.3389/fimmu.2011.00035. eCollection 2011. PMID: 22566825 PMCID: PMC3342056 read article


Fletcher AL, Malhotra D, Turley SJ. Lymph node stroma broaden the peripheral tolerance paradigm. Trends Immunol. 2011 Jan;32(1):12-8. doi: 10.1016/j.it.2010.11.002. Epub 2010 Dec 10. PMID: 21147035 PMCID: PMC3163075 read article


Brown DR, Calpe S, Keszei M, Wang N, McArdel S, Terhorst C, Sharpe AH. Cutting edge: an NK cell-independent role for slamf4 in controlling humoral autoimmunity. J Immunol. 2011 Jul 1;187(1):21-5. doi: 10.4049/jimmunol.1100510. Epub 2011 May 27.PMID 21622868 PMCID: PMC3119727 read article


Li S, Moffett HF, Lu J, Werner L, Zhang H, Ritz J, Neuberg D, Wucherpfennig KW, Brown JR, Novina CD. MicroRNA expression profiling identifies activated B cell status in chronic lymphocytic leukemia cells. PLoS One. 2011 Mar 8;6(3):e16956. PubMed PMID: 21408091; PubMed Central PMCID: PMC3050979.


Pessach IM, Ordovas-Montanes J, Zhang SY, Casanova JL, Giliani S, Gennery AR, Al-Herz W, Manos PD, Schlaeger TM, Park IH, Rucci F, Agarwal S, Mostoslavsky G, Daley GQ, Notarangelo LD. Induced pluripotent stem cells: A novel frontier in the study of human primary immunodeficiencies. J Allergy Clin Immunol. 2011 Jun;127(6):1400-1407.e4. Epub 2010 Dec 24. PMID: 21185069 PMCID: PMC3081993. read article


Moskwa P, Buffa FM, Pan Y, Panchakshari R, Gottipati P, Muschel RJ, Beech J, Kulshrestha R, Abdelmohsen K, Weinstock DM, Gorospe M, Harris AL, Helleday T, Chowdhury D. miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors. Mol Cell. 2011 Jan 21;41(2):210-20. Epub 2010 Dec 30. PMID: 21195000 PMCID: PMC3249932 read article


Srikantan S, Abdelmohsen K, Lee EK, Tominaga K, Subaran SS, Kuwano Y, Kulshrestha R, Panchakshari R, Kim HH, Yang X, Martindale JL, Marasa BS, Kim MM, Wersto RP, Indig FE, Chowdhury D, Gorospe M. Translational control of TOP2A influences doxorubicin efficacy. Mol Cell Biol. 2011 Sep;31(18):3790-801. doi: 10.1128/MCB.05639-11. Epub 2011 Jul 18. PMID: 21768308; PMCID: PMC3165726 . read article


Sillé FC, Martin C, Jayaraman P, Rothchild A, Fortune S , Besra GS, Behar SM, Boes M. Requirement for Invariant chain in macrophages for Mycobacterium tuberculosis replication and CD1d antigen presentation. Infect Immun. 2011 Aug;79(8):3053-63. doi: 10.1128/IAI.01108-10. Epub 2011 May 16. PMID: 21576321 PMCID: PMC3147586 read article


Sillé FC, Martin C, Jayaraman P, Rothchild A, Besra GS, Behar SM, Boes M. Critical role for invariant chain in CD1d-mediated selection and maturation of Vα14-invariant NKT cells. Immunol Lett. 2011 Sep 30;139(1-2):33-41. doi: 10.1016/j.imlet.2011.04.012. Epub 2011 May 5. PMID: 21565221 PMCID: PMC3146573 read article


Jin Y, Chauhan SK, Annan JE, Sage PT, Sharpe AH, Dana R. A novel function for programmed death ligand-1 regulation of angiogenesis. Am J Pathol. 2011 Apr;178(4):1922-9. PMCID: PMC3078456.


Riella LV, Watanabe T, Sage PT, Yang J, Yeung M, Azzi J, Vanguri V, Chandraker A, Sharpe AH, Sayegh MH, Najafian N. Essential role of PDL1 expression on nonhematopoietic donor cells in acquired tolerance to vascularized cardiac allografts. Am J Transplant. 2011 Apr;11(4):832-40.


Kriegel MA, Sefik E, Hill JA, Wu HJ, Benoist C, Mathis D. Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11548-53. doi: 10.1073/pnas.1108924108. Epub 2011 Jun 27. PMID: 21709219 PMCID: PMC3136249 read article


Koh KP, Yabuuchi A, Rao S, Huang Y, Cunniff K, Nardone J, Laiho A, Tahiliani M, Sommer CA, Mostoslavsky G, Lahesmaa R, Orkin SH, Rodig SJ, Daley GQ, Rao A. Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell. 2011 Feb 4;8(2):200-13. PMID: 21295276. PMCID: PMC313431.


Pastor WA, Pape UJ, Huang Y, Henderson HR, Lister R, Ko M, McLoughlin EM, Brudno Y, Mahapatra S, Kapranov P, Tahiliani M, Daley GQ, Liu XS, Ecker JR, Milos PM, Agarwal S, Rao A. Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature. 2011 May 19;473(7347):394-7. Epub 2011 May 8. PMID: 21552279. PMCID: PMC3124347.


Vander Lugt B, Beck ZT, Fuhlbrigge RC, Hacohen N, Campbell JJ, Boes M. TGF-β Suppresses β-Catenin-Dependent Tolerogenic Activation Program in Dendritic Cells. PLoS One. 2011;6(5):e20099. Epub 2011 May 20. PMID: 21625453. PMCID: PMC3098869


Wheeler LA, Trifonova R, Vrbanac V, Basar E, McKernan S, Xu Z, Seung E, Deruaz M, Dudek T, Einarsson JI, Yang L, Allen TM, Luster AD, Tager AM, Dykxhoorn DM, Lieberman J. Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras. J Clin Invest. 2011 Jun 1;121(6):2401-12. doi: 10.1172/JCI45876. Epub 2011 May 16. PubMed PMID: 21576818; PubMed Central PMCID: PMC3104760.


Yan N, O'Day E, Wheeler LA, Engelman A, Lieberman J. HIV DNA is heavily uracilated, which protects it from autointegration. Proc Natl Acad Sci U S A. 2011 May 31;108(22):9244-9. Epub 2011 May 16. PubMed PMID: 21576478; PubMed Central PMCID: PMC3107311.


Gonzalez SF, Degn SE, Pitcher LA, Woodruff M, Heesters BA, Carroll MC. Trafficking of B cell antigen in lymph nodes. Annu Rev Immunol. 2011;29:215-33. doi: 10.1146/annurev-immunol-031210-101255. PMID: 21219172


Woodworth JS, Shin D, Volman M, Nunes-Alves C, Fortune SM, Behar SM. Mycobacterium tuberculosis directs immunofocusing of CD8+ T cell responses despite vaccination. J Immunol. 2011 Feb 1;186(3):1627-37. Epub 2010 Dec 22. PubMed PMID: 21178003; PubMed Central PMCID: PMC3133636.


Basu U, Meng FL, Keim C, Grinstein V, Pefanis E, Eccleston J, Zhang T, Myers D, Wasserman CR, Wesemann DR, Januszyk K, Gregory RI, Deng H, Lima CD, Alt FW. The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell. 2011 Feb 4;144(3):353-63. PMCID: PMC3065114.


Ise W, Kohyama M, Schraml BU, Zhang T, Schwer B, Basu U, Alt FW, Tang J, Oltz EM, Murphy TL, Murphy KM. The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nature Immunology. 2011 May 15. PMCID: PMC3117275.


top

2010


Albacker LA, Karisola P, Chang YJ, Umetsu SE, Zhou M, Akbari O, Kobayashi N, Baumgarth N, Freeman GJ, Umetsu DT, DeKruyff RH. (2010) TIM-4, a Receptor for Phosphatidylserine, Controls Adaptive Immunity by Regulating the Removal of Antigen-Specific T Cells. Journal of Immunology. 185(11):6839-49. PMID: 21037090 PMCID: PMC3153437


Chang YJ, Kim HY, Albacker LA, Lee HH, Baumgarth N, Akira S, Savage PB, Endo S, Yamamura T, Maaskant J, Kitano N, Singh A, Bhatt A, Besra GS, van den Elzen P, Appelmelk B, Franck RW, Chen G, DeKruyff RH, Shimamura M, Illarionov P, Umetsu DT. Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity. J Clin Invest. 2011 Jan 4;121(1):57-69. doi: 10.1172/JCI44845. Epub 2010 Dec 13. PMID: 21157038 PMCID: PMC3007162


Giallourakis CC, Franklin A, Guo C, Cheng HL, Yoon HS, Gallagher M, Perlot T, Andzelm M, Murphy AJ, Macdonald LE, Yancopoulos GD, Alt FW. Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination. Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22207-12. Epub 2010 Dec 1. PubMed PMID: 21123744; PubMed Central PMCID: PMC3009784. read article


Liu H, Chi AW, Arnett KL, Chiang MY, Xu L, Shestova O, Wang H, Li YM, Bhandoola A, Aster JC, Blacklow SC, Pear WS. Notch dimerization is required for leukemogenesis and T-cell development. Genes Dev. 2010 Nov 1;24(21):2395-407. Epub 2010 Oct 8. PubMed PMID: 20935071; PubMed Central PMCID: PMC2964750.


Arnett KL, Hass M, McArthur DG, Ilagan MX, Aster JC, Kopan R, Blacklow SC. Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. Nat Struct Mol Biol. 2010 Nov;17(11):1312-7. Epub 2010 Oct 24. PubMed PMID: 20972443; PubMed Central PMCID: PMC3024583.


Barker BR, Gladstone MN, Gillard GO, Panas MW, Letvin NL. Critical role for IL-21 in both primary and memory anti-viral CD8+ T cell responses. European Journal of Immunology, 2010; 40(11):3085-96. PMCID: PMC3119210.


Zhang T, Franklin A, Boboila C, McQuay A, Gallagher MP, Manis JP, Khamlichi AA, Alt FW. Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3040-5. Epub 2010 Feb 1. PubMed PMID: 20133637; PubMed Central PMCID: PMC2840363.


Boboila C, Jankovic M, Yan CT, Wang JH, Wesemann DR, Zhang T, Fazeli A, Feldman L, Nussenzweig A, Nussenzweig M, Alt FW. Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3034-9. Epub 2010 Jan 25. PubMed PMID: 20133803; PubMed Central PMCID: PMC2840344.


Zhang Y, Gostissa M, Hildebrand DG, Becker MS, Boboila C, Chiarle R, Lewis S, Alt FW. The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers. Adv Immunol. 2010;106:93-133. Review. PubMed PMID: 20728025; PubMed Central PMCID: PMC3073861.


Boboila C, Yan C, Wesemann DR, Jankovic M, Wang JH, Manis J, Nussenzweig A, Nussenzweig M, Alt FW. Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4. J Exp Med. 2010 Feb 15;207(2):417-27. doi: 10.1084/jem.20092449. Epub 2010 Feb 8. PMID: 20142431 PMCID: PMC2822597 read article


Zhang T, Franklin A, Boboila C, McQuay A, Gallagher MP, Manis JP, Khamlichi AA, Alt FW. Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3040-5. doi: 10.1073/pnas.0915072107. Epub 2010 Feb 1. PMID: 20133637 PMCID: PMC2840363 read article


Brown KE, Freeman GJ, Wherry EJ, Sharpe AH. Role of PD-1 in regulating acute infections. Curr Opin Immunol. 2010 Jun;22(3):397-401. Epub 2010 Apr 27. Review. PubMed PMID: 20427170; PubMed Central PMCID: PMC2905659.


Cedeno-Laurent F, Barthel SR, Opperman MJ, Lee DM, Clark RA, Dimitroff CJ. Development of a nascent galectin-1 chimeric molecule for studying the role of leukocyte galectin-1 ligands and immune disease modulation. J Immunol. 2010 Oct 15;185(8):4659-72. Epub 2010 Sep 15. PubMed PMID: 20844192; PubMed Central PMCID:PMC2953643.


Haas MS, Alicot EM, Schuerpf F, Chiu I, Li J, Moore FD, Carroll MC. Blockade of self-reactive IgM significantly reduces injury in a murine model of acute myocardial infarction. Cardiovasc Res. 2010 Sep 1;87(4):618-27. Epub 2010 May 11. PMID: 20462867. PMCID: PMC2920809.


Beriou G, Bradshaw EM, Lozano E, Costantino CM, Hastings WD, Orban T, Elyaman W, Khoury SJ, Kuchroo VK, Baecher-Allan C, Hafler DA. TGF-beta induces IL-9 production from human Th17 cells. J Immunol. 2010 Jul 1;185(1):46-54. Epub 2010 May 24. PubMed PMID: 20498357; PubMed Central PMCID: PMC2936106.


Sakaguchi S, Miyara M, Costantino CM, Hafler DA. FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol. 2010 Jul;10(7):490-500. Epub 2010 Jun 18. Review. PubMed PMID: 20559327.


Tu C, Ortega-Cava CF, Winograd P, Stanton MJ, Reddi AL, Dodge I, Arya R, Dimri M, Clubb RJ, Naramura M, Wagner KU, Band V, Band H. Endosomal-sorting complexes required for transport (ESCRT) pathway-dependent endosomal traffic regulates the localization of active Src at focal adhesions. Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16107-12. Epub 2010 Aug 30. PubMed PMID: 20805499; PubMed Central PMCID: PMC2941294.


Dougan ML, Dougan S, Slisz J, Firestone B, Vanneman M, Draganov D, Goyal G, Li W, Neuberg D, Blumberg R, Hacohen N, Porter D, Zawel L, Dranoff G. IAP inhibitors enhance co-stimulation to promote tumor immunity. J Exp Med. 2010 Sep 27;207(10):2195-206. Epub 2010 Sep 13. PMID: 20837698


Zeissig S, Dougan SK, Barral DC, Junker Y, Chen Z, Kaser A, Ho M, Mandel H, McIntyre A, Kennedy SM, Painter GF, Veerapen N, Besra GS, Cerundolo V, Yue S, Beladi S, Behar SM, Chen X, Gumperz JE, Breckpot K, Raper A, Baer A, Exley MA, Hegele RA, Cuchel M, Rader DJ, Davidson NO, Blumberg RS. Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function. J Clin Invest. 2010 Aug 2;120(8):2889-99. doi: 10.1172/JCI42703. Epub 2010 Jul 1. PubMed PMID: 20592474; PubMed Central PMCID: PMC2912200.


Dougan M, Dougan S, Slisz J, Firestone B, Vanneman M, Draganov D, Goyal G, Li W, Neuberg D, Blumberg R, Hacohen N, Porter D, Zawel L, Dranoff G. IAP inhibitors enhance co-stimulation to promote tumor immunity. J Exp Med. 2010 Sep 27;207(10):2195-206. Epub 2010 Sep 13. PubMed PMID: 20837698; PubMed Central PMCID: PMC2947073.


Dougan M, Dougan S, Slisz J, Firestone B, Vanneman M, Draganov D, Goyal G, Li W, Neuberg D, Blumberg R, Hacohen N, Porter D, Zawel L, Dranoff G. IAP inhibitors enhance co-stimulation to promote tumor immunity. J Exp Med. 2010 Sep 27;207(10):2195-206. Epub 2010 Sep 13. PubMed PMID: 20837698; PubMed Central PMCID: PMC2947073.


Odyniec AN, Barral DC, Garg S, Tatituri RV, Besra GS, Brenner MB. Regulation of CD1 antigen-presenting complex stability. J Biol Chem. 2010 Apr 16;285(16):11937-47. Epub 2010 Feb 4. PMID: 20133943 PMCID: PMC2852931


Dougan M, Dougan S, Slisz J, Firestone B, Vanneman M, Draganov D, Goyal G, Li W, Neuberg D, Blumberg R, Hacohen N, Porter D, Zawel L, Dranoff G. IAP inhibitors enhance co-stimulation to promote tumor immunity. J Exp Med. 2010 Sep 27;207(10):2195-206. Epub 2010 Sep 13. PubMed PMID: 20837698; PubMed Central PMCID: PMC2947073. read article


Greenblatt MB, Shim, JH, Zou W, Sitara D, Schweitzer M, Hu D, Lotinun S, Sano Y, Baron R, Park JM, Arathur S, Xie M, Schneider MD, Zhai B, Gygi S, Davis R. Glimcher LH. The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice.J Clin Invest. 2010 Jul 1; 120(7):2457073.doe: 10. 1172/JCI42285. Epub 2010 Jun 14. doi: 10.1172/JCI42285. PMID: 20551513. PMCID: PMC2898605.


Greenblatt MB, Aliprantis A, Hu B, Glimcher LH. Calcineurin regulates innate antifungal immunity in neutrophils. J Exp Med. 2010 May 10;207(5):923-31. Epub 2010 Apr 26. PMID: 20421389 PMCID: PMC2867274


Greenblatt MB, Shim JH, Glimcher LH. TAK1 mediates BMP signaling in cartilage. Ann N Y Acad Sci. 2010 Mar;1192(1):385-90. PMID: 20392264. PMCID: PMC3096020


Iannacone M, Moseman EA, Tonti E, Bosurgi L, Junt T, Henrickson SE, Whelan SP, Guidotti LG, von Andrian UH. Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus. Nature. 2010 Jun 24;465(7301):1079-83. PMID: 20577213 PMCID: PMC2892812


Boscacci RT, Pfeiffer F, Gollmer K, Sevilla AI, Martin AM, Soriano SF, Natale D, Henrickson S, von Andrian UH, Fukui Y, Mellado M, Deutsch U, Engelhardt B, Stein JV. Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing. Blood. 2010 Aug 12;116(6):915-25. Epub 2010 Apr 15. PMID: 20395417. PMCID: PMC3324225


Henrickson SE, DiMarzio EA, Wang Q, Stanford VM, Kasianowicz JJ. Probing single nanometer-scale pores with polymeric molecular rulers. J Chem Phys. 2010 Apr 7;132(13):135101. PMID: 20387958


Textor J, Peixoto A, Henrickson SE, Sinn M, von Andrian UH, Westermann J.Defining the quantitative limits of intravital two-photon lymphocyte tracking.Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12401-6. Epub 2011 Jul 6.PMID:21734152. PMCID: PMC3145739


Park B, Spooner E, Houser BL, Strominger JL, Ploegh HL. The HCMV membrane glycoprotein US10 selectively targets HLA-G for degradation. J Exp Med. 2010 Aug 30;207(9):2033-41. Epub 2010 Aug 16. PMCID: PMC2931171.


Koh AS, Kingston RE, Benoist C, Mathis D. Global relevance of Aire binding to hypomethylated lysine-4 of histone-3. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13016-21. Epub 2010 Jul 6. PMID: 20615959 PMCID: PMC2919944.


Ghosh S, Koralov SB, Stevanovic I, Sundrud MS, Sasaki Y, Rajewsky K, Rao A, Müller M. Hyperactivation of NFAT1 in T cells attenuates development of murine autoimmune encephalomyelitis. PNAS 2010 Aug 24;107(34):15169-74. PMID: 20696888. PMC2930568.


Kreslavsky T, Gleimer M, Garbe AI, von Boehmer H. αβ versus γδ fate choice: counting the T-cell lineages at the branch point. Immunol Rev. 2010 Nov;238(1):169-81. doi: 10.1111/j.1600-065X.2010.00947.x. Review. PubMed PMID: 20969592; PubMed Central PMCID: PMC3031133.


Kreslavsky T, Gleimer M, von Boehmer H. Alphabeta versus gammadelta lineage choice at the first TCR-controlled checkpoint. Curr Opin Immunol. 2010 Apr;22(2):185-92. Epub 2010 Jan 13. Review. PubMed PMID: 20074925; PubMed Central PMCID: PMC2861550.


Kreslavsky T, von Boehmer H. gammadeltaTCR ligands and lineage commitment. Semin Immunol. 2010 Aug;22(4):214-21. Epub 2010 May 5. Review. PubMed PMID: 20447836; PubMed Central PMCID: PMC2912151.


Mitsdoerffer M, Lee Y, Jäger A, Kim HJ, Korn T, Kolls JK, Cantor H, Bettelli E, Kuchroo VK. Proinflammatory T helper type 17 cells are effective B-cell helpers. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14292-7. doi: 10.1073/pnas.1009234107. Epub 2010 Jul 26. PMID: 20660725 PMCID: PMC2922571. read article


Maciag K, Kishore SP. Generic drugs for developing nations. Nat Rev Microbiol. 2010 Jul;8(7):530. doi: 10.1038/nrmicro2345-c1. PMID: 20531275


Zhang T, Franklin A, Boboila C, McQuay A, Gallagher MP, Manis JP, Khamlichi AA, Alt FW. Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3040-5. Epub 2010 Feb 1. PubMed PMID: 20133637. PMCID: PMC2840363.


Paust S, Gill HS, Wang BZ, Flynn MP, Moseman EA, Senman B, Szczepanik M, Telenti A, Askenase PW, Compans RW, von Andrian UH. Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. Nat Immunol. 2010 Dec;11(12):1127-35. Epub 2010 Oct 24. PubMed PMID: 20972432; PubMed Central PMCID: PMC2982944


Bao X, Moseman EA, Saito H, Petryanik B, Thiriot A, Hatakeyama S, Ito Y, Kawashima H, Yamaguchi Y, Lowe JB, von Andrian UH, Fukuda M. Endothelial heparan sulfate controls chemokine presentation in recruitment of lymphocytes and dendritic cells to lymph nodes. Immunity. 2010 Nov 24;33(5):817-29. PubMed PMID: 21093315; PubMed Central PMCID: PMC2996097


Iannacone M, Moseman EA, Tonti E, Bosurgi L, Junt T, Henrickson SE, Whelan SP, Guidotti LG, von Andrian UH. Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus. Nature. 2010 Jun 24;465(7301):1079-83. PubMed PMID: 20577213; PubMed Central PMCID: PMC2892812


Mamo T, Moseman EA, Kolishetti N, Salvador-Morales C, Shi J, Kuritzkes DR,Langer R, von Andrian U, Farokhzad OC. Emerging nanotechnology approaches for HIV/AIDS treatment and prevention. Nanomedicine (Lond). 2010 Feb;5(2):269-85. Review. PubMed PMID: 20148638; PubMed Central PMCID: PMC2861897


Liang X, Moseman EA, Farrar MA, Bachanova V, Weisdorf DJ, Blazar BR, Chen W. Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells. Blood. 2010 Jun 17;115(24):5041-52. Epub 2010 Mar 25. PubMed PMID: 20339095; PubMed Central PMCID: PMC2890142


Surolia I, Pirnie SP, Chellappa V, Taylor KN, Cariappa A, Moya J, Liu H, Bell DW, Driscoll DR, Diederichs S, Haider K, Netravali I, Le S, Elia R, Dow E, Lee A, Freudenberg J, De Jager PL, Chretien Y, Varki A, Macdonald ME, Gillis T, Behrens TW, Bloch D, Collier D, Korzenik J, Podolsky DK, Hafler D, Murali M, Sands B, Stone JH, Gregersen PK, Pillai S. Functionally defective germline variants of sialic acid acetylesterase in autoimmunity. Nature. 2010 Jul 8;466(7303):243-7. doi: 10.1038/nature09115. Epub 2010 Jun 16. PMID: 20555325 PMCID: PMC2900412 read article


Yoshida T, Ng SY, Georgopoulos K. Awakening lineage potential by Ikaros-mediated transcriptional priming. Curr Opin Immunol. 2010 Apr;22(2):154-60. Epub 2010 Mar 17. Review. PubMed PMID: 20299195.


Barker BR, Gladstone MN, Gillard GO, Panas MW, Letvin NL. Critical role for IL-21 in both primary and memory anti-viral CD8+ T-cell responses..Eur J Immunol. 2010 Nov;40(11):3085-96. doi: 10.1002/eji.200939939. Epub 2010 Oct 27. PMID:21061439. PMCID: PMC3119210.


Fletcher AL, Lukacs-Kornek V, Reynoso ED, Pinner SE, Bellemare-Pelletier A, Curry MS, Collier AR, Boyd RL, Turley SJ. Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions. J Exp Med. 2010 Apr 12;207(4):689-97. Epub 2010 Mar 22. PubMed PMID: 20308362; PubMed Central PMCID: PMC2856033.


Rodriguez-Manzanet R, Sanjuan MA, Wu HY, Quintana FJ, Xiao S, Anderson AC, Weiner HL, Green DR, Kuchroo VK. T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice. Proc Natl Acad Sci U S A. 2010 May 11;107(19):8706-11. Epub 2010 Apr 5. PMID: 20368430 PMCID: PMC2889349


Mayadas TN, Rosetti F, Ernandez T, Sethi S. Neutrophils: game changers in glomerulonephritis? Trends Mol Med. 2010 Aug;16(8):368-78. Epub 2010 Jul 29. Review. PMID: 20667782 PMCID: PMC2925238. read article


Garces A, Atmakuri K, Chase MR, Woodworth JS, Krastins B, Rothchild AC, Ramsdell TL, Lopez MF, Behar SM, Sarracino DA, Fortune SM. EspA acts as a critical mediator of ESX1-dependent virulence in Mycobacterium tuberculosis by affecting bacterial cell wall integrity. PLoS Pathog. 2010 Jun 24;6(6):e1000957. doi: 10.1371/journal.ppat.1000957. PMID: 20585630 PMCID: PMC2891827 read article


Anderson AC, Lord GM, Dardalhon V, Lee DH, Sabatos-Peyton CA, Glimcher LH, Kuchroo VK. (2010). T-bet, a Th1 transcription factor regulates the expression of Tim-3. Eur J Immunol. 40:859-866. PMC2837127.


Francisco LM, Sage PT, Sharpe AH. The PD-1 pathway in tolerance and autoimmunity. Immunol Rev. 2010 Jul;236:219-42. PMCID: PMC2919275.


Koduru, S., L. Kumar, M. J. Massaad, N. Ramesh, S. Le Bras, E. Ozcan, M. K. Oyoshi, M. Kaku, Y. Fujiwara, L. Kremer, S. King, R. Fuhlbrigge, S. Rodig, P. Sage, C. Carman, P. Alcaide, F. W. Luscinskas, and R. S. Geha. 2010. Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking. Proc Natl Acad Sci U S A 107:16252-16256.


Sircar P, Furr KL, Dorosh LA, Letvin NL. Clonal repertoires of virus-specific CD8+ T lymphocytes are shared in mucosal and systemic compartments during chronic simian immunodeficiency virus infection in rhesus monkeys. J Immunol. 2010 Aug 15;185(4):2191-9. Epub 2010 Jul 12. PMID: 20624939.


Younan G, Suber F, Xing W, Shi T, Kunori Y, Abrink M, Pejler G, Schlenner SM, Rodewald HR, Moore FD Jr, Stevens RL, Adachi R, Austen KF, Gurish MF. The inflammatory response after an epidermal burn depends on the activities of mouse mast cell proteases 4 and 5.J Immunol. 2010 Dec 15;185(12):7681-90. doi: 10.4049/jimmunol.1002803. Epub 2010 Nov 12. PMID: 21076070 PMCID: PMC3058366.  read article


Huang Y, Pastor WA, Shen Y, Tahiliani M, Liu DR, Rao A. The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing. PLoS One (2010) 5: 8888. PMID: 20126651. PMCID: PMC2811190.


Ko M, Huang Y, Jankowska AM, Pape UJ, Tahiliani M, Bandukwala HS, An J, Lamperti ED, Koh KP, Ganetzky R, Liu XS, Aravind L, Agarwal S, Maciejewski JP, Rao A. Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature. 2010 Dec 9;468(7325):839-43. PMID: 21057493. PMCID: PMC3003755.


Zha S, Bassing CH, Sanda T, Brush JW, Patel H, Goff PH, Murphy MM, Tepsuporn S, Gatti RA, Look AT, Alt FW. ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification. J Exp Med. 2010 Jul 5;207(7):1369-80. Epub 2010 Jun 21. PubMed PMID: 20566716. PMCID: PMC2901073.


Nishio J, Feuerer M, Wong J, Mathis D, Benoist C. Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor-specified peripheral niche constraints. J Exp Med. 2010 Aug 30;207(9):1879-89. Epub 2010 Aug 2. PMID: 20679403. PMCID: PMC2931163.


Musunuru K, Strong A, Frank-Kamenetsky M, Lee NE, Ahfeldt T, Sachs KV, Li X, Li H, Kuperwasser N, Ruda VM, Pirruccello JP, Muchmore B, Prokunina-Olsson L, Hall JL, Schadt EE, Morales CR, Lund-Katz S, Phillips MC, Wong J, Cantley W, Racie T, Ejebe KG, Orho-Melander M, Melander O, Koteliansky V, Fitzgerald K, Krauss RM, Cowan CA, Kathiresan S, Rader DJ. From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature. 2010 Aug 5;466(7307):714-9. PMID: 20686566. PMCID: PMC3062476.


Garces A, Atmakuri K, Chase MR, Woodworth JS, Krastins B, Rothchild AC, Ramsdell TL, Lopez MF, Behar SM, Sarracino DA, Fortune SM. EspA acts as a critical mediator of ESX1-dependent virulence in Mycobacterium tuberculosis by affecting bacterial cell wall integrity. PLoS Pathog. 2010 Jun 24;6(6):e1000957. PubMed PMID: 20585630; PubMed Central PMCID: PMC2891827.


Zha S, Guo C, Boboila C, Oksenych V, Cheng HL, Zhang Y, Wesemann DR, Yuen G, Patel H, Goff PH, Dubois RL, Alt FW. ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks. Nature. 2011 Jan 13;469(7329):250-4. doi: 10.1038/nature09604. Epub 2010 Dec 15. PMID: 21160472 PMCID: PMC3058373 read article


Zhang T, Franklin A, Boboila C, McQuay A, Gallagher MP, Manis JP, Khamlichi AA, Alt FW. Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions. Proceedings of the National Academy of Sciences USA. 2010 Feb 16;107(7):3040-5. PMCID: PMC2840363.


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2009


Francisco LM, Salinas VH, Brown KE, Vanguri VK, Freeman GJ, Kuchroo VK, Sharpe AH. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med. 2009 Dec 21;206(13):3015-29. Epub 2009 Dec 14. PubMed PMID: 20008522; PubMed Central PMCID: PMC2806460.


Amit I, Garber M, Chevrier N, Leite AP, Donner Y, Eisenhaure T, Guttman M, Grenier JK, Li W, Zuk O, Schubert LA, Birditt B, Shay T, Goren A, Zhang X, Smith Z, Deering R, McDonald RC, Cabili M, Bernstein BE, Rinn JL, Meissner A, Root DE, Hacohen N, Regev A. Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses. Science. 2009 Oct 9;326(5950):257-63. Epub 2009 Sep 3. PMID: 19729616 PMCID: PMC2879337 read article


Chiu IM, Phatnani H, Kuligowski M, Tapia JC, Carrasco MA, Zhang M, Maniatis T, Carroll MC. Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice. Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20960-5. Epub 2009 Nov 20. PMID: 19933335. PMCID: PMC2791631.


Kuo TT, de Muinck EJ, Claypool SM, Yoshida M, Nagaishi T, Aveson VG, Lencer WI, Blumberg RS. N-glycan moieties in FcRn determine steady-state membrane distribution and directional transport of IgG. J Biol Chem. 2009 Mar 27;284(13):8292-300. PMCID: PMC2659187.


Cohen NR, Garg S, Brenner MB. Antigen Presentation by CD1 Lipids, T Cells, and NKT Cells in Microbial Immunity. Adv Immunol. 2009;102:1-94. Review. PubMed PMID: 19477319.


Chiba, A; Cohen, N; Brigl, M; Brennan, PJ; Besra, GS & Brenner, MB. Rapid and reliable generation of invariant natural killer T cell lines in vitro. Immunology. 2009. 128(3):324-33. PMCID: PMC2770680.


Cornejo MG, Kharas MG, Werneck MB, Le Bras S, Moore SA, Rodig S, Aster JC, Lee BH, Cantor H, Gilliland DG, Mercher T. Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models. Blood, 2009 Mar 19; 113 (12); 2746-54. PMCID: PMC2661862.


Mercher T, Raffel GD, Moore SA, Cornejo MG, Baudry-Bluteau D, Cagnard N, Jesneck JL, Pikman Y, Cullen D, Williams IR, Akashi K, Shigematsu H, Bourquin JP, Giovannini M, Vainchenker W, Levine RL, Lee BH, Bernard OA, Gilliland DG.The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model. J Clin Invest. 2009 Apr; 119 (4):852-64. PMCID: PMC2662544.


Hofmann I, Stover EH, Cullen DE, Mao J, Morgan KJ, Lee BH, Kharas MG, Miller PG, Cornejo MG, Okabe R, Armstrong SA, Ghilardi N, Gould S, de Sauvage FJ, McMahon AP, Gilliland DG. Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis. Cell Stem Cell. 2009 Jun 5; 4(6):559-67. PMCID: PMC3065323.


Moellering RE, Cornejo MG, Del Bianco C, Hancock M, Aster JC, Blacklow SC, Gilliland DG, Verdine GL, Bradner JE. Direct Inhibition of the Notch Transcription Factor Complex. Nature. 2009 Nov 12; 462(7270): 182-8. PMCID: PMC2951323.


Cornejo MG, Boggon TJ, Mercher T. JAK3: a two-faced player in hematological disorders. (Int J Biochem Cell Biol. 2009 Dec; 41(12): 2376-9) PMCID: PMC2853879.


Costantino CM, Ploegh HL, Hafler DA. Cathepsin S regulates class II MHC processing in human CD4+ HLA-DR+ T cells. J Immunol. 2009 Jul 15;183(2):945-52. Epub 2009 Jun 24. PubMed PMID: 19553543; PubMed Central PMCID: PMC2752291.


Beriou G, Costantino CM, Ashley CW, Yang L, Kuchroo VK, Baecher-Allan C, Hafler DA. IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood. 2009 Apr 30;113(18):4240-9. Epub 2009 Jan 26. PubMed PMID: 19171879; PubMed Central PMCID: PMC2676084.


Amit I, Garber M, Chevrier N, Leite AP, Donner Y, Eisenhaure T, Guttman M, Grenier JK, Li W, Zuk O, Schubert LA, Birditt B, Shay T, Goren A, Zhang X, Smith Z, Deering R, McDonald RC, Cabili M, Bernstein BE, Rinn JL, Meissner A, Root DE, Hacohen N, Regev A. Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses. Science. 2009 Oct 9;326(5950):257-63. doi: 10.1126/science.1179050. Epub 2009 Sep 3. PMID: 19729616 PMCID: PMC2879337 read article


Djuretic IM, Cruz-Guilloty F, Rao A. Regulation of gene expression in peripheral T cells by Runx transcription factors. Adv Immunol. 2009;104:1-23. Epub 2009 Dec 1. Review. PubMed PMID: 20457114.


Cruz-Guilloty F, Pipkin ME, Djuretic IM, Levanon D, Lotem J, Lichtenheld MG, Groner Y, Rao A. Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs. J Exp Med. 2009 Jan 16;206(1):51-9. Epub 2009 Jan 12. PubMed PMID: 19139168; PubMed Central PMCID: PMC2626671.


Dougan M, Dranoff G. The immune response to tumors. Curr Protoc Immunol. 2009 Apr;Chapter 20:Unit 20.11. PMID: 19347848


Dougan M, Dranoff G.Immune Therapy for Cancer. Annu Rev Immunol. 2009;27:83-117. Review. PMID: 19007331


Hu CC, Dougan SK, McGehee AM, Love JC, Ploegh HL. XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells. EMBO J. 2009 Jun 3;28(11):1624-36. Epub 2009 Apr 30. PubMed PMID: 19407814; PubMed Central PMCID: PMC2684024.


Cohen NR, Garg S, Brenner MB. Antigen Presentation by CD1 Lipids, T Cells, and NKT Cells in Microbial Immunity. Adv Immunol. 2009;102:1-94. Review. PMID: 19477319


Veerapen N, Brigl M, Garg S, Cerundolo V, Cox LR, Brenner MB, Besra GS. Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4288-91. Epub 2009 May 27. PMID: 19502056. PMCID: PMC2722241


Shim JH, Greenblatt MB, Xie M, Schneider MD, Zou W, Zhai B, Gygi S, Glimcher LH. TAK1 is an essential regulator of BMP signalling in cartilage. EMBO J. 2009 Jul 22;28(14):2028-41. Epub 2009 Jun 18. PMID: 19536134


Beltman JB, Henrickson SE, von Andrian UH, de Boer RJ, Marée AF. Towards estimating the true duration of dendritic cell interactions with T cells. J Immunol Methods. 2009 Aug 15;347(1-2):54-69. Epub 2009 Jun 9. PMID: 19520083


Li C, Houser BL, Nicotra ML, Strominger JL. HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human decidual macrophages and natural killer cells. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5767-72. Epub 2009 Mar 20. PMCID: PMC2667005.


Sundrud MS, Koralov SB, Feuerer M, Calado DP, Kozhaya AE, Rhule-Smith A, Lefebvre RE, Unutmaz D, Mazitschek R, Waldner H, Whitman M, Keller T, Rao A. Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science. 2009 Jun 5;324(5932):1334-8. PMCID: PMC2803727.


Kreslavsky T, Savage AK, Hobbs R, Gounari F, Bronson R, Pereira P, Pandolfi PP, Bendelac A, von Boehmer H. TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12453-8. Epub 2009 Jul 15. PubMed PMID: 19617548; PubMed Central PMCID: PMC2718370.


Van Rhijn I, Young DC, De Jong A, Vazquez J, Cheng TY, Talekar R, Barral DC, León L, Brenner MB, Katz JT, Riese R, Ruprecht RM, O'Connor PB, Costello CE, Porcelli SA, Briken V, Moody DB. CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids. J Exp Med. 2009 Jun 8;206(6):1409-22. Epub 2009 May 25. Erratum in: J Exp Med. 2009 Aug 3;206(8):1831. Barral, Duarte [corrected to Barral, Duarte C]. PubMed PMID: 19468063; PubMed Central PMCID: PMC2715062.


McLaughlin KA, Chitnis T, Newcombe J, Franz B, Kennedy J, McArdel S, Kuhle J, Kappos L, Rostasy K, Pohl D, Gagne D, Ness JM, Tenembaum S, O'Connor KC, Viglietta V, Wong SJ, Tavakoli NP, de Seze J, Idrissova Z, Khoury SJ, Bar-Or A, Hafler DA, Banwell B, Wucherpfennig KW. Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis. J Immunol. 2009 Sep 15;183(6):4067-76. doi: 10.4049/jimmunol.0801888. Epub 2009 Aug 17. PMID: 19687098 PMCID: PMC2795331 read article


Amit I, Garber M, Chevrier N, Leite AP, Donner Y, Eisenhaure T, Guttman M, Grenier JK, Li W, Zuk O, Schubert LA, Birditt B, Shay T, Goren A, Zhang X, Smith Z, Deering R, McDonald RC, Cabili M, Bernstein BE, Rinn JL, Meissner A, Root DE, Hacohen N, Regev A. Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses. Science. 2009 Oct 9;326(5950):257-63. Epub 2009 Sep 3. PMID: 19729616 PMCID: PMC2879337 read article


McLaughlin KA, Chitnis T, Newcombe J, Franz B, Kennedy J, McArdel S, Kuhle J, Kappos L, Rostasy K, Pohl D, Gagne D, Ness JM, Tenembaum S, O'Connor KC, Viglietta V, Wong SJ, Tavakoli NP, de Seze J, Idrissova Z, Khoury SJ, Bar-Or A, Hafler DA, Banwell B, Wucherpfennig KW. Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis. J Immunol. 2009 Sep 15;183(6):4067-76. Epub 2009 Aug 17. PMID: 19687098. PMCID: PMC2795331.


Hofmann I, Stover EH, Cullen DE, Mao J, Morgan KJ, Lee BH, Kharas MG, Miller PG, Cornejo MG, Okabe R, Armstrong SA, Ghilardi N, Gould S, de Sauvage FJ, McMahon AP, Gilliland DG. Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis. Cell Stem Cell. 2009 Jun 5;4(6):559-67. PMID: 19497284. PMCID: PMC3065323. NIHMSID: NIHMS189973


Ng SY, Yoshida T, Zhang J, Georgopoulos K. Genome-wide lineage-specific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells. Immunity. 2009 Apr 17;30(4):493-507. Epub 2009 Apr 2. PubMed PMID: 19345118; PubMed Central PMCID: PMC3012962.


Hovav AH, Santosuosso M, Bivas-Benita M, Plair A, Cheng A, Elnekave M, Righi E, Chen T, Kashiwagi S, Panas MW, Xiang SH, Furmanov K, Letvin NL, Poznansky MC X4 human immunodeficiency virus type 1 gp120 down-modulates expression and immunogenicity of codelivered antigens..J Virol. 2009 Nov;83(21):10941-50. Epub 2009 Aug 19.PMID:19692474. PMCID: PMC2772807.


Reynoso ED, Turley SJ. Unconventional antigen-presenting cells in the induction of peripheral CD8(+) T cell tolerance. J Leukoc Biol. 2009 Oct;86(4):795-801. Epub 2009 Aug 3. Review. PubMed PMID: 19652027.


Reynoso ED, Elpek KG, Francisco L, Bronson R, Bellemare-Pelletier A, Sharpe AH, Freeman GJ, Turley SJ. Intestinal tolerance is converted to autoimmune enteritis upon PD-1 ligand blockade. J Immunol. 2009 Feb 15;182(4):2102-12. PubMed PMID: 19201863.


Reynoso ED, Lee JW, Turley SJ. Peripheral tolerance induction by lymph node stroma. Adv Exp Med Biol. 2009;633:113-27. Review. PubMed PMID: 19209685.


Sage PT, Carman CV. Settings and mechanisms for trans-cellular diapedesis. Front Biosci. 2009 Jun 1;14:5066-83.


Iyer LM, Tahiliani M, Rao A, Aravind L. Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids. Cell Cycle (2009) 8(11): 1698-1710. PMID: 19411852. PMCID: PMC2995806.


Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, Agarwal S, Iyer LM, Liu DR, Aravind L, Rao A. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by the MLL fusion partner, TET1. Science (2009) 324 (5929): 930-5. PMID: 19372391. PMCID: PMC2715015.


Cornejo MG, Kharas MG, Werneck MB, Le Bras S, Moore SA, Ball B, Beylot-Barry M, Rodig SJ, Aster JC, Lee BH, Cantor H, Merlio JP, Gilliland DG, Mercher T. Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models. Blood. 2009 Mar 19;113(12):2746-54. Epub 2009 Jan 12. PubMed PMID: 19139084; PubMed Central PMCID: PMC2661862.


Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A, Lee J, Goldfine AB, Benoist C, Shoelson S, Mathis D. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med. 2009 Aug;15(8):930-9. Epub 2009 Jul 26. PMID: 19633656. PMCID: PMC3115752.


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2008


Gordon WR, Arnett KL, Blacklow SC. The molecular logic of Notch signaling-a structural and biochemical perspective. J Cell Sci. 2008 Oct 1;121(Pt 19):3109-19. Review. PubMed PMID: 18799787; PubMed Central PMCID: PMC2696053.


Vig M, Dehaven WI, Bird GS, Billingsley JM, Wang H, Rao PE, Hutchings AB, Jouvin MH, Putney JW, Kinet JP. 2008. Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels. Nat. Immunol. 9(1); 89-96. PMCID: PMC2377025.


Franco S, Murphy MM, Li G, Borjeson T, Boboila C, Alt FW. DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination. J Exp Med. 2008 Mar 17;205(3):557-64. Epub 2008 Mar 3. PubMed PMID: 18316419; PubMed Central PMCID: PMC2275379.


Cariappa A, Takematsu H, Liu H, Diaz S, Haider K, Boboila C, Kalloo G, Connole M, Shi HN, Varki N, Varki A, Pillai S. B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase. J Exp Med. 2009 Jan 16;206(1):125-38. Epub 2008 Dec 22. PubMed PMID: 19103880; PubMed Central PMCID: PMC2626685.


Butty V, Campbell C, Mathis D, Benoist C; DPT-1 Study Group. Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).Diabetes. 2008 Sep;57(9):2348-59. Epub 2008 Jun 12. PMID:18556337. PMCID: PMC2518486.


Johnsen AK, Plenge RM, Butty V, Campbell C, Dieguez-Gonzalez R, Gomez-Reino JJ, Shadick N, Weinblatt M, Gonzalez A, Gregersen PK, Benoist C, Mathis D. A broad analysis of IL1 polymorphism and rheumatoid arthritis. Arthritis Rheum. 2008 Jul;58(7):1947-57. PMID:18576312. PMCID: PMC2533126.


Xu C, Gagnon E, Call ME, Schnell JR, Schwieters CD, Carman CV, Chou JJ, Wucherpfennig KW. Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif. Cell. 2008 Nov 14;135(4):702-13. PubMed PMID: 19013279; PubMed Central PMCID: PMC2597348.


Cedeno-Laurent F, Bryant J, Fishelevich R, Jones OD, Deng A, Eng ML, Gaspari AA, Trujillo JR. Inflammatory papillomatous hyperplasia and epidermal necrosis in a transgenic rat for HIV-1. J Dermatol Sci. 2009 Feb;53(2):112-9. Epub 2008 Nov 11. PubMed PMID: 19004620; PubMed Central PMCID: PMC3125122.


Chiu IM, Chen A, Zheng Y, Kosaras B, Tsiftsoglou SA, Vartanian TK, Brown RH Jr, Carroll MC. T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS. Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17913-8. Epub 2008 Nov 7. PMID: 18997009. PMCID: PMC2581614.


Dickinson BL, Claypool SM, Aiken ML, D'Angelo JA, Venu N, Yen EH, Wagner JS, Borawski JA, Pierce AT, Hershberg R, Blumberg RS, Lencer WI. Ca2+-dependent calmodulin-binding to FcRn sorts between the transcytotic and lysosomal pathways. Mol Biol Cell. 2008 Jan;19(1):414-23. PMCID: PMC2174181.


Leadbetter EA, Brigl M, Illarionov P, Cohen N, Luteran MC, Pillai S, Besra GS, Brenner MB. NK T cells provide lipid antigen-specific cognate help for B cells. Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8339-44. Epub 2008 Jun 11. PMID: 18550809 PMCID: PMC2448838


Hava DL, van der Wel N, Cohen N, Dascher CC, Houben D, León L, Agarwal S, Sugita M, van Zon M, Kent SC, Shams H, Peters PJ, Brenner MB. Evasion of peptide, but not lipid antigen presentation, through pathogen-induced dendritic cell maturation. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11281-6. Epub 2008 Aug 6. PMID: 18685099 PMCID: PMC2516216


Kindler T, Cornejo MG, Scholl C, Liu J, Leeman DS, Haydu JE, Fröhling S, Lee BH, Gilliland DG. K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors. Blood. 2008 Oct 15;112(8):3373-82. Epub 2008 Jul 28. PubMed PMID: 18663146; PubMed Central PMCID: PMC2569181.


Costantino CM, Hang HC, Kent SC, Hafler DA, Ploegh HL. Lysosomal cysteine and aspartic proteases are heterogeneously expressed and act redundantly to initiate human invariant chain degradation. J Immunol. 2008 Mar 1;180(5):2876-85. PubMed PMID: 18292509.


Costantino CM, Baecher-Allan C, Hafler DA. Multiple sclerosis and regulatory T cells. J Clin Immunol. 2008 Nov;28(6):697-706. Epub 2008 Sep 2. Review. PubMed PMID: 18763026; PubMed Central PMCID: PMC2752287.


Costantino CM, Baecher-Allan CM, Hafler DA. Human regulatory T cell and autoimmunity. Eur J Immunol. 2008 Apr;38(4):921-4. Review. PubMed PMID: 18395861; PubMed Central PMCID: PMC2752283.


Dougan M, Dranoff G. Inciting inflammation: the RAGE about tumor promotion.J Exp Med. 2008 Feb 18;205(2):267-70. Epub 2008 Feb 11. PMID: 18268042


Hussain MM, Rava P, Pan X, Dai K, Dougan SK, Iqbal J, Lazare F, Khatun I. Microsomal triglyceride transfer protein in plasma and cellular lipid metabolism. Curr Opin Lipidol. 2008 Jun;19(3):277-84. Review. PubMed PMID: 18460919.


Jinushi M, Nakazaki Y, Carrasco DR, Draganov D, Souders N, Johnson M, Mihm MC,Dranoff G. Milk fat globule EGF-8 promotes melanoma progression through coordinated Akt and twist signaling in the tumor microenvironment. Cancer Res. 2008 Nov 1;68(21):8889-98. PubMed PMID: 18974133.


Heng TS, Painter MW; Immunological Genome Project Consortium (Elpek K, Lukacs-Kornek V, Mauermann N, Turley SJ, Koller D, Kim FS, Wagers AJ, Asinovski N, Davis S, Fassett M, Feuerer M, Gray DH, Haxhinasto S, Hill JA, Hyatt G, Laplace C, Leatherbee K, Mathis D, Benoist C, Jianu R, Laidlaw DH, Best JA, Knell J, Goldrath AW, Jarjoura J, Sun JC, Zhu Y, Lanier LL, Ergun A, Li Z, Collins JJ, Shinton SA, Hardy RR, Friedline R, Sylvia K, Kang J.) The Immunological Genome Project: networks of gene expression in immune cells.Nat Immunol. 2008 Oct;9(10):1091-4.PMID: 18800157


Barral DC, Cavallari M, McCormick PJ, Garg S, Magee AI, Bonifacino JS, De Libero G, Brenner MB. CD1a and MHC class I follow a similar endocytic recycling pathway.Traffic. 2008 Sep;9(9):1446-57. Epub 2008 Jun 28. PMID: 18564371. PMCID: PMC3839101


Henrickson SE, Mempel TR, Mazo IB, Liu B, Artyomov MN, Zheng H, Peixoto A, Flynn MP, Senman B, Junt T, Wong HC, Chakraborty AK, von Andrian UH. T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation.Nat Immunol. 2008 Mar;9(3):282-91. Epub 2008 Jan 20. PMID: 18204450. PMCID: PMC2698867


Henrickson SE, Mempel TR, Mazo IB, Liu B, Artyomov MN, Zheng H, Peixoto A, Flynn M, Senman B, Junt T, Wong HC, Chakraborty AK, von Andrian UH. In vivo imaging of T cell priming. Sci Signal. 2008 Mar 25;1(12):pt2. PMID: 18364513


Zheng H, Jin B, Henrickson SE, Perelson AS, von Andrian UH, Chakraborty AK. How antigen quantity and quality determine T-cell decisions in lymphoid tissue.Mol Cell Biol. 2008 Jun;28(12):4040-51. Epub 2008 Apr 21. PMID: 18426917. PMCID: PMC2423119


Koh AS, Kuo AJ, Park SY, Cheung P, Abramson J, Bua D, Carney D, Shoelson SE, Gozani O, Kingston RE, Benoist C, Mathis D. Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15878-83. Epub 2008 Oct 7. PMID: 18840680 PMCID: PMC2572939


Mesaros A***, Koralov SB***, Rother E, Wunderlich FT, Ernst MB, Barsh GS, Rajewsky K, Brüning JC. Activation of Stat3 signaling in AgRP neurons promotes locomotor activity. Cell Metab. 2008 Mar;7(3):236-48. ***Denotes equal contribution.


Koralov SB, Muljo SA, Galler GR, Krek A, Chakraborty T, Kanellopoulou C, Jensen K, Cobb BS, Merkenschlager M, Rajewsky N, Rajewsky K. Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell. 2008 Mar 7;132(5):860-74.


Egawa T, Kreslavsky T, Littman DR, von Boehmer H. Lineage diversion of T cell receptor transgenic thymocytes revealed by lineage fate mapping. PLoS One. 2008 Jan 30;3(1):e1512. PubMed PMID: 18231598; PubMed Central PMCID: PMC2211402.


Kreslavsky T, Garbe AI, Krueger A, von Boehmer H. T cell receptor-instructed alphabeta versus gammadelta lineage commitment revealed by single-cell analysis. J Exp Med. 2008 May 12;205(5):1173-86. Epub 2008 Apr 28. PubMed PMID: 18443226; PubMed Central PMCID: PMC2373848.


Hava DL, van der Wel N, Cohen N, Dascher CC, Houben D, León L, Agarwal S, Sugita M, van Zon M, Kent SC, Shams H, Peters PJ, Brenner MB. Evasion of peptide, but not lipid antigen presentation, through pathogen-induced dendritic cell maturation. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11281-6. Epub 2008 Aug 6. PubMed PMID: 18685099; PubMed Central PMCID: PMC2516216.


Werneck MB, Lugo-Villarino G, Hwang ES, Cantor H, Glimcher LH. T-bet plays a key role in NK-mediated control of melanoma metastatic disease. J Immunol. 2008 Jun 15;180(12):8004-10. PubMed PMID: 18523263.


McLaughlin KA, Wucherpfennig KW. B cells and autoantibodies in the pathogenesis of multiple sclerosis and related inflammatory demyelinating diseases. Adv Immunol. 2008;98:121-49. Review. PMID: 18772005.


Verginis P, McLaughlin KA, Wucherpfennig KW, von Boehmer H, Apostolou I. Induction of antigen-specific regulatory T cells in wild-type mice: visualization and targets of suppression. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3479-84. Epub 2008 Feb 25. PMID: 18299571. PMCID: PMC2265184.


Kawamura K, McLaughlin KA, Weissert R, Forsthuber TG. Myelin-reactive type B T cells and T cells specific for low-affinity MHC-binding myelin peptides escape tolerance in HLA-DR transgenic mice. J Immunol. 2008 Sep 1;181(5):3202-11. PMID: 18713991. PMCID: PMC2724067.


Rodriguez-Manzanet R, Meyers JH, Balasubramanian S, Slavik J, Kassam N, Dardalhon V, Greenfield EA, Anderson AC, Sobel RA, Hafler DA, Strom TB, Kuchroo VK. TIM-4 expressed on APCs induces T cell expansion and survival. J Immunol. 2008 Apr 1;180(7):4706-13. PubMed PMID: 18354194; PubMed Central PMCID: PMC2948965.


Love TM, Moffett HF, Novina CD. Not miR-ly small RNAs: big potential for microRNAs in therapy. J Allergy Clin Immunol. 2008 Feb;121(2):309-19. Review. PubMed PMID: 18269923.


Yoshida T, Hazan I, Zhang J, Ng SY, Naito T, Snippert HJ, Heller EJ, Qi X, Lawton LN, Williams CJ, Georgopoulos K. The role of the chromatin remodeler Mi-2beta in hematopoietic stem cell self-renewal and multilineage differentiation. Genes Dev. 2008 May 1;22(9):1174-89. PubMed PMID: 18451107; PubMed Central PMCID: PMC2335314.


Ansel KM, Pastor WA, Rath N, Lapan AD, Glasmacher E, Wolf C, Smith LC, Papadopoulou N, Lamperti ED, Tahiliani M, Ellwart J, Shi YJ, Kremmer E, Rao A, Heissmeyer V. Mouse ERI-1 interacts with the ribosome and catalyzes 5.8S rRNA processing. Nature Structural Biology (2008) 15(5): 523-30. PMID: 18438418. PMCID: PMC3032500.


Venanzi ES, Melamed R, Mathis D, Benoist C. The variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcription. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15860-5. Epub 2008 Oct 6. PubMed PMID: 18838677; PubMed Central PMCID: PMC2572942.


Villaseñor J, Besse W, Benoist C, Mathis D. Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15854-9. Epub 2008 Oct 3. PubMed PMID: 18836079; PubMed Central PMCID: PMC2572966.


Wein MN, Jones DC, Glimcher LH. Lentivirus delivery of shRNA constructs into osteoblasts.Methods Mol Biol. 2008;455:149-55. PMID: 18463817


Mukherjee S, Raje N, Schoonmaker JA, Liu JC, Hideshima T, Wein MN, Jones DC, Vallet S, Bouxsein ML, Pozzi S, Chhetri S, Seo YD, Aronson JP, Patel C, Fulciniti M, Purton LE, Glimcher LH, Lian JB, Stein G, Anderson KC, Scadden DT. Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice.J Clin Invest. 2008 Feb;118(2):491-504. PMID: 18219387 PMCID: PMC2213372


Werneck MB, Lugo-Villarino G, Hwang ES, Cantor H, Glimcher LH. T-bet plays a key role in NK-mediated control of melanoma metastatic disease. J Immunol. 2008 Jun 15;180(12):8004-10. PubMed PMID: 18523263.


Lu L, Kim HJ, Werneck MB, Cantor H. Regulation of CD8+ regulatory T cells: Interruption of the NKG2A-Qa-1 interaction allows robust suppressive activity and resolution of autoimmune disease. Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19420-5. Epub 2008 Dec 1. PubMed PMID: 19047627; PubMed Central PMCID: PMC2614776.


Woodworth JS, Fortune SM, Behar SM. Bacterial protein secretion is required for priming of CD8+ T cells specific for the Mycobacterium tuberculosis antigen CFP10. Infect Immun. 2008 Sep;76(9):4199-205. Epub 2008 Jun 30. PubMed PMID: 18591224; PubMed Central PMCID: PMC2519428.


Wu Y, Woodworth JS, Shin DS, Morris S, Behar SM. Vaccine-elicited 10-kilodalton culture filtrate protein-specific CD8+ T cells are sufficient to mediate protection against Mycobacterium tuberculosis infection. Infect Immun. 2008 May;76(5):2249-55. Epub 2008 Mar 10. PubMed PMID: 18332205; PubMed Central PMCID: PMC2346695.


Woodworth JS, Wu Y, Behar SM. Mycobacterium tuberculosis-specific CD8+ T cells require perforin to kill target cells and provide protection in vivo. J Immunol. 2008 Dec 15;181(12):8595-603. PubMed PMID: 19050279; PubMed Central PMCID: PMC3133658.


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2007


Wang JP, Asher DR, Chan M, Kurt-Jones EA, Finberg RW. Cutting Edge: Antibody-mediated TLR7-dependent recognition of viral RNA. Journal of Immunology (2007) 178: 3363-3367.


Barker BR, Parvani JG, Meyer D, Hey AS, Skak K, Letvin NL. IL-21 Induces Apoptosis of Antigen-Specific CD8+ T Lymphocytes. Journal of Immunology, 2007; 179: 3596-3603.


Moran ST, Cariappa A, Liu H, Muir B, Sgroi D, Boboila C, Pillai S. Synergism between NF-kappa B1/p50 and Notch2 during the development of marginal zone B lymphocytes. J Immunol. 2007;179(1):195-200


Cariappa A, Boboila C, Moran ST, Liu H, Shi HN, Pillai S. The recirculating B cell pool contains two functionally distinct, long-lived, posttransitional, follicular B cell populations. J Immunol. 2007;179(4):2270-81


Yan CT, Boboila C, Souza EK, Franco S, Hickernell TR, Murphy M, Gumaste S, Geyer M, Zarrin AA, Manis JP, Rajewsky K, Alt FW. IgH class switching and translocations use a robust non-classical end-joining pathway. Nature. 2007;449(7161):478-82.


Gauguet JM, Bonasio R and von Andrian UH. High endothelial venules. In: The Endothelium: A Comprehensive Reference. (2007) Aird WC (ed.). Cambridge University Press (ISBN 9780521853767), pp. 1568-1588.


Bonasio R, Carman CV, Kim E, Sage PT, Love KR, Mempel TR, Springer TA, von Andrian UH (2007). Specific and covalent labeling of a membrane protein with organic fluorochromes and quantum dots. Proceedings of the National Academy of Sciences 104:14753-8. PMID: 17785425; PMCID: PMC1976196.


Rodacki M, Svoren B, Butty V, Besse W, Laffel L, Benoist C, Mathis D. Altered natural killer cells in type 1 diabetic patients. Diabetes. 2007 Jan;56(1):177-85. PMID:17192480.


Butty V, Roy M, Sabeti P, Besse W, Benoist C, Mathis D. Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes. Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):570-5. Epub 2006 Dec 29. PMID:17197413.


Garibyan L, Lobito AA, Siegel RM, Call ME, Wucherpfennig KW, Geha RS. Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID). J Clin Invest. 2007 Jun;117(6):1550-7. Epub 2007 May 10. PubMed PMID: 17492055; PubMed Central PMCID: PMC1865037.


Call ME, Wucherpfennig KW. Common themes in the assembly and architecture of activating immune receptors. Nat Rev Immunol. 2007 Nov;7(11):841-50. Review. PubMed PMID: 17960150.


Catic A, Misaghi S, Korbel GA, Ploegh HL. ElaD, a deubiquitinating protease expressed by E. coli. PLoS ONE. 2007 Apr;2(4):e381.


Catic A, Sun ZY, Ratner D, Misaghi S, Galardy PG, Korbel GA, Spooner E, Samuelson J, Wagner G, Ploegh HL. Sequence and structure evolved separately in a ribosomal ubiquitin variant. EMBO J. 2007 Jul;26(14):3474-83.


Catic A, Fiebiger E, Korbel GA, Blom D, Galardy PJ, Ploegh HL. Screen for ISG15-crossreactive deubiquitinases. PLoS ONE. 2007 Jul;2(7):e679.


Love KR, Catic A, Schlieker C, Ploegh HL. Mechanism, biology and inhibitors of deubiquitinating enzymes. Nat. Chem. Biol. 2007 Nov;3(11):697-705. Review.


Matthews AG, Kuo AJ, Ramón-Maiques S, Han S, Champagne KS, Ivanov D, Gallardo M, Carney D, Cheung P, Ciccone DN, Walter KL, Utz PJ, Shi Y, Kutateladze TG, Yang W, Gozani O, Oettinger MA. RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature. 2007 Dec 13;450(7172):1106-10. Epub 2007 Nov 21. PubMed PMID: 18033247; PubMed Central PMCID: PMC2988437.


Gu TL, Mercher T, Tyner JW, Goss VL, Walters DK, Cornejo MG, Reeves C, Popova L, Lee K, Rush J, Daibata M, Miyoshi I, Gilliland DG, Druker BJ, Polakiewicz RD. A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia. Blood, 2007 Jul 1; 110 (1): 323-33.


Djuretic IM, Levanon D, Negreanu V, Groner Y, Rao A, Ansel KM. Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat Immunol. 2007 Feb;8(2):145-53. Epub 2006 Dec 31. PubMed PMID: 17195845.


Hu H, Djuretic I, Sundrud MS, Rao A. Transcriptional partners in regulatory T cells: Foxp3, Runx and NFAT. Trends Immunol. 2007 Aug;28(8):329-32. Epub 2007 Jul 6. PubMed PMID: 17618833.


Jinushi M, Nakazaki Y, Dougan M, Carrasco DR, Mihm M, Dranoff G. MFG-E8-mediated uptake of apoptotic cells by APCs links the pro- and antiinflammatory activities of GM-CSF. J Clin Invest. 2007 Jul;117(7):1902-13. PMID: 17557120 PMCID: PMC1884688


Enzler T, Gillessen S, Dougan M, Allison JP, Neuberg D, Oble DA, Mihm M, Dranoff G. Functional deficiencies of granulocyte-macrophage colony stimulating factor and interleukin-3 contribute to insulitis and destruction of {beta}-cells. Blood. 2007 May 4; [Epub ahead of print] PMID: 17483299 PMCID: PMC1924767


Dougan SK, Rava P, Hussain MM, Blumberg RS. MTP regulated by an alternate promoter is essential for NKT cell development. J Exp Med. 2007 Mar 19;204(3):533-45. Epub 2007 Feb 20. PubMed PMID: 17312007; PubMed Central PMCID: PMC2137905.


Dougan SK, Kaser A, Blumberg RS. CD1 expression on antigen-presenting cells. Curr Top Microbiol Immunol. 2007;314:113-41. Review. PubMed PMID: 17593659. Zeissig S, Kaser A, Dougan SK, Nieuwenhuis EE, Blumberg RS. Role of NKT cells in the digestive system. III. Role of NKT cells in intestinal immunity. Am J Physiol Gastrointest Liver Physiol. 2007 Dec;293(6):G1101-5. Epub 2007 Aug 23. PubMed PMID: 17717040.


Zeissig S, Kaser A, Dougan SK, Nieuwenhuis EE, Blumberg RS. Role of NKT cells in the digestive system. III. Role of NKT cells in intestinal immunity. Am J Physiol Gastrointest Liver Physiol. 2007 Dec;293(6):G1101-5. Epub 2007 Aug 23. PubMed PMID: 17717040.


Henrickson SE, Hartmann EM, Ott G., Rosenwald A. Gene expression profiling in malignant lymphomas. Adv Exp Med Biol. 2007;593:134-46. Review. PMID: 17265723


Henrickson SE, von Andrian UH. Single-cell dynamics of T-cell priming. Curr Opin Immunol. 2007 Jun;19(3):249-58. Epub 2007 Apr 12. PMID: 17433876


Hauser AE, Junt T, Mempel TR, Sneddon MW, Kleinstein SH, Henrickson SE, von Andrian UH, Shlomchik MJ, Haberman AM. Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns. Immunity. 2007 May;26(5):655-67. PMID: 17509908


Junt T, Moseman EA, Iannacone M, Massberg S, Lang PA, Boes M, Fink K, Henrickson SE, Shayakhmetov DM, Di Paolo NC, van Rooijen N, Mempel TR, Whelan SP, von Andrian UH. Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature. 2007 Nov 1;450(7166):110-4. Epub 2007 Oct 14. PMID: 17934446


Edry E, Koralov SB, Rajewsky K, Melamed D. Spontaneous Class Switch Recombination in B Cell Lymphopoiesis Generates Aberrant Switch Junctions and Is Increased after VDJ Rearrangement. J Immunol. 2007. Nov 15;179(10):6555-60.


Kitamoto S, Sukhova GK, Sun J, Yang M, Libby P, Love V, Duramad P, Sun C, Zhang Y, Yang X, Peters C, Shi GP. Cathepsin L deficiency reduces diet-induced atherosclerosis in low-density lipoprotein receptor-knockout mice. Circulation. 2007 Apr 17;115(15):2065-75. Epub 2007 Apr 2. PubMed PMID: 17404153.


Love VA, Grabie N, Duramad P, Stavrakis G, Sharpe A, Lichtman A. CTLA-4 ablation and interleukin-12 driven differentiation synergistically augment cardiac pathogenicity of cytotoxic T lymphocytes. Circ Res. 2007 Aug 3;101(3):248-57. Epub 2007 Jun 14. PubMed PMID: 17569889.


Garrett WS, Lord GM, Punit S, Lugo-Villarino G, Mazmanian SK, Ito S, Glickman JN, Glimcher LH. Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell. 2007 Oct 5;131(1):33-45. PubMed PMID: 17923086;PubMed Central PMCID: PMC2169385.


Ramón-Maiques S, Kuo AJ, Carney D, Matthews AG, Oettinger MA, Gozani O, Yang W. The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2. Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):18993-8. Epub 2007 Nov 19. PubMed PMID: 18025461; PubMed Central PMCID: PMC2141896.


Matthews AG, Kuo AJ, Ramón-Maiques S, Han S, Champagne KS, Ivanov D, Gallardo M, Carney D, Cheung P, Ciccone DN, Walter KL, Utz PJ, Shi Y, Kutateladze TG, Yang W, Gozani O, Oettinger MA. RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature. 2007 Dec 13;450(7172):1106-10. Epub 2007 Nov 21. PubMed PMID: 18033247; PubMed Central PMCID: PMC2988437.


O'Connor KC, McLaughlin KA, De Jager PL, Chitnis T, Bettelli E, Xu C, Robinson WH, Cherry SV, Bar-Or A, Banwell B, Fukaura H, Fukazawa T, Tenembaum S, Wong SJ, Tavakoli NP, Idrissova Z, Viglietta V, Rostasy K, Pohl D, Dale RC, Freedman M, Steinman L, Buckle GJ, Kuchroo VK, Hafler DA, Wucherpfennig KW. Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein. Nat Med. 2007 Feb;13(2):211-7. Epub 2007 Jan 12. PMID: 17237795.


Moffett HF, Novina CD. A small RNA makes a Bic difference. Genome Biol. 2007;8(7):221. Review. PubMed PMID: 17666120; PubMed Central PMCID: PMC2323214.


Moran ST, Cariappa A, Liu H, Muir B, Sgroi D, Boboila C, Pillai S. Synergism between NF-kappa B1/p50 and Notch2 during the development of marginal zone B lymphocytes. J Immunol. 2007. Jul 1;179(1):195-200. PMID:17579038.


Cariappa A, Boboila C, Moran ST, Liu H, Shi HN, Pillai S. The recirculating B cell pool contains two functionally distinct, long-lived, posttransitional, follicular B cell populations. J Immunol. 2007. Aug 15;179(4):2270-81. PMID:17675488.


Massberg S, Schaerli P, Knezevic-Maramica I, Köllnberger M, Tubo N, Moseman EA, Huff IV, Junt T, Wagers AJ, Mazo IB, von Andrian UH. Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. Cell. 2007 Nov 30;131(5):994-1008. PubMed PMID: 18045540; PubMed Central PMCID: PMC2330270


de Paz JL, Moseman EA, Noti C, Polito L, von Andrian UH, Seeberger PH. Profiling heparin-chemokine interactions using synthetic tools. ACS Chem Biol. 2007 Nov 20;2(11):735-44. PubMed PMID: 18030990; PubMed Central PMCID: PMC2716178


Junt T, Moseman EA, Iannacone M, Massberg S, Lang PA, Boes M, Fink K, Henrickson SE, Shayakhmetov DM, Di Paolo NC, van Rooijen N, Mempel TR, Whelan SP, von Andrian UH. Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature. 2007 Nov 1;450(7166):110-4. Epub 2007 Oct 14. PubMed PMID: 17934446


Jayasekera JP, Moseman EA, Carroll MC. Natural antibody and complement mediate neutralization of influenza virus in the absence of prior immunity. J Virol. 2007 Apr;81(7):3487-94. Epub 2007 Jan 3. PubMed PMID: 17202212; PubMed Central PMCID: PMC1866020


Hovav AH, Panas MW, Osuna CE, Cayabyab MJ, Autissier P, Letvin NL. 2007. The impact of a boosting immunogen on the differentiation of secondary memory CD8+ T cells. J Virol. 2007 Dec;81(23):12793-802.


Hovav AH, Panas MW, Osuna CE, Cayabyab MJ, Autissier P, Letvin NL.The impact of a boosting immunogen on the differentiation of secondary memory CD8+ T cells. J Virol. 2007 Dec;81(23):12793-802. Epub 2007 Sep 19. PMID:17881444. PMCID: PMC2169130.


Hovav AH, Panas MW, Rahman S, Sircar P, Gillard G, Cayabyab MJ, Letvin NL.Duration of antigen expression in vivo following DNA immunization modifies the magnitude, contraction, and secondary responses of CD8+ T lymphocytes. J Immunol. 2007 Nov 15;179(10):6725-33. PMID:17982062


Li J, Brieher WM, Scimone ML, Kang SJ, Zhu H, Yin H, von Andrian UH, Mitchison T, Yuan J. Caspase-11 regulates cell migration by promoting Aip1 Cofilin-mediated actin depolymerization. Nat Cell Biol. 2007 Mar;9(3):276-86. Epub 2007 Feb 11. Erratum in: Nat Cell Biol. 2007 Apr;9(4):480. PubMed PMID: 17293856.


Hovav AH, Panas MW, Rahman S, Sircar P, Gillard G, Cayabyab MJ, Letvin NL. Duration of antigen expression in vivo following DNA immunization modifies the magnitude, contraction, and secondary responses of CD8+ T lymphocytes. J Immunol. 2007 Nov 15;179(10):6725-33. PMC2190620.


Tahiliani M, Mei P, Fang R, Leonor T, Rutenberg M, Shimizu F, Li J, Rao A, Shi Y. The Histone H3K4 Demethylase SMCX Links REST Target Genes to X-Linked Mental Retardation. Nature (2007) 447: 601-5. PMID: 17468742.


Venanzi ES, Gray DH, Benoist C, Mathis D. Lymphotoxin pathway and Aire influences on thymic medullary epithelial cells are unconnected. J Immunol. 2007 Nov 1;179(9):5693-700. PubMed PMID: 17947641.


Glimcher LH, Jones DC, Wein MN. Control of postnatal bone mass by the zinc finger adapter protein Schnurri-3.Ann N Y Acad Sci. 2007 Nov;1116:174-81. Review. PMID: 18083927


Jones DC, Wein MN, Glimcher LH. Schnurri-3 is an essential regulator of osteoblast function and adult bone mass.Ann Rheum Dis. 2007 Nov;66 Suppl 3:iii49-51. Review. PMID: 17934096


Jones DC, Wein MN, Glimcher LH. Schnurri-3: a key regulator of postnatal skeletal remodeling. Adv Exp Med Biol. 2007;602:1-13. PMID: 17966382


Lu L, Ikizawa K, Hu D, Werneck MB, Wucherpfennig KW, Cantor H. Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Immunity. 2007 May;26(5):593-604. PubMed PMID: 17509909.


Moza B, Varma AK, Buonpane RA, Zhu P, Herfst CA, Nicholson MJ, Wilbuer AK, Seth NP, Wucherpfennig KW, McCormick JK, Kranz DM, Sundberg EJ. Structural basis of T-cell specificity and activation by the bacterial superantigen TSST-1. EMBO J. 2007 Feb 21;26(4):1187-97. Epub 2007 Feb 1. PMID: 17268555 PMCID: PMC1852840


Wong J, Obst R, Correia-Neves M, Losyev G, Mathis D, Benoist C. Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4+ T cells. J Immunol. 2007 Jun 1;178(11):7032-41. PMID: 17513752.


Wong J, Mathis D, Benoist C. TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets. J Exp Med. 2007 Sep 3;204(9):2039-45. Epub 2007 Aug 27. PMID: 17724131.


Behar SM, Woodworth JS, Wu Y. Next generation: tuberculosis vaccines that elicit protective CD8+ T cells. Expert Rev Vaccines. 2007 Jun;6(3):441-56. Review. PubMed PMID: 17542758; PubMed Central PMCID: PMC3134449.


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2006


Pau AK, McLaughlin MM, Hu Z, Agyemang AF, Polis MA, Kottilil S. Predictors for Hematopoietic Growth Factors Use in HIV/HCV-Coinfected Patients Treated with Peginterferon Alfa 2b and Ribavirin. AIDS Patient Care STDS. 2006 Sep;20(9):612-9. PMID: 16987047


Keir ME, Liang SC, Guleria I, Latchman YE, Qipo A, Albacker LA, Koulmanda M, Freeman GJ, Sayegh MH, Sharpe AH. Tissue expression of PD-L1 mediates peripheral T cell tolerance. J Exp Med. 2006 Apr 17;203(4):883-95. Epub 2006 Apr 10. PMID: 16606670 PMCID: PMC2118286


Balsara ZR, Roan NR, Steele LN, Starnbach MN. Developmental regulation of Chlamydia trachomatis class I accessible protein-1, a CD8+ T cell antigen. J Infect Dis. 2006 May 15;193(10):1459-63. Epub 2006 Apr 12. PMID: 16619195.


Balsara ZR, Misaghi S, Lafave JN, Starnbach MN. Chlamydia trachomatis infection induces cleavage of the mitotic cyclin B1. Infect Immun. 2006 Oct;74(10):5602-8. PMC1594933.


Bernstein-Hanley I, Coers J, Balsara ZR, Taylor GA, Starnbach MN, Dietrich WF. The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3 and mediate cellular resistance in mice. Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14092-7. Epub 2006 Sep 7. PMC1599917.


Letvin NL, Mascola JR, Sun Y, Gorgone DA, Buzby AP, Xu L, Yang Z, Chakrabarti B, Rao SS, Schmitz JE, Montefiori DC, Barker BR, Bookstein FL, Nabel GJ. Preserved CD4+ Central Memory T Cells and Survival in Vaccinated SIV-Challenged Monkeys. Science, 2006; 312:1530-1533.


Sun Y, Schmitz JE, Buzby AP, Barker BR, Rao SS, Xu L, Yang Z, Mascola JR, Nabel GJ, Letvin NL. Virus-specific Cellular Immune Correlates of Survival in Vaccinated Monkeys After Simian Immunodeficiency Virus Challenge. Journal of Virology, 2006; 80(22):10950-6. PMCID: PMC1642180.


Vig M***, Beck A***, Billingsley JM***, Lis A, Parvez S, Peinelt C, Koomoa DL, Soboloff J, Gill DL, Fleig A, Kinet JP, Penner R. 2006. CRACM1 multimers form the ion-selective pore of the CRAC channel. Curr Biol. 16(20):2073-9. PMID: 16978865.***Equal Contribution.


Moran ST, Cariappa A, Liu H, Boboila C, Shi HN, Holland PM, Peschon JJ, Pillai S. Protein kinase C-associated kinase is not required for the development of peripheral B lymphocyte populations. Mol Immunol. 2006;43(10):1694-9.


Bonasio R, von Andrian UH. (2006). Origin, destination and function of circulating dendritic cells. Current Opinions in Immunology 18:503-11. PMID: 16777395.


Bonasio R, Scimone ML, Schaerli P, Grabie N, Lichtman AH, von Andrian UH (2006). Clonal deletion of autoreactive thymocytes by circulating dendritic cells homing to the thymus. Nature Immunology 7:1092-100. PMID: 16951687.


Wu Y, Borde M, Heissmeyer V, Feuerer M, Lapan AD, Stroud JC, Bates DL, Guo L, Han A, Ziegler SF, Mathis D, Benoist C, Chen L, Rao A. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell. 2006 Jul 28;126(2):375-87.PubMed PMID: 16873067.


Barrington RA, Borde M, Rao A, Carroll MC. Involvement of NFAT1 in B cell self-tolerance. J Immunol. 2006 Aug 1;177(3):1510-5. PubMed PMID: 16849457.


Hu H, Wang B, Borde M, Nardone J, Maika S, Allred L, Tucker PW, Rao A. Foxp1 is an essential transcriptional regulator of B cell development. Nat Immunol. 2006 Aug;7(8):819-26. Epub 2006 Jul 2. PubMed PMID: 16819554.


Tomczak MF, Gadjeva M, Wang YY, Brown K, Maroulakou I, Tsichlis PN, Erdman SE, Fox JG, Horwitz BH. Defective activation of ERK in macrophages lacking the p50/p105 subunit of NF-kappaB is responsible for elevated expression of IL-12 p40 observed after challenge with Helicobacter hepaticus. J Immunol. 2006 Jan 15;176(2):1244-51. PubMed PMID: 16394015.


Yeh WW, Cale EM, Jaru-Ampornpan P, Lord CI, Peyerl FW, Letvin NL. Compensatory substitutions restore normal core assembly in simian immunodeficiency virus isolates with Gag epitope cytotoxic T-lymphocyte escape mutations. J Virol. 2006 Aug;80(16):8168-77. PMID: 16873273 PMCID: PMC1563819


Wang B, Love TM, Call ME, Doench JG, Novina CD. Recapitulation of short RNA-directed translational gene silencing in vitro. Mol Cell. 2006 May 19;22(4):553-60. PubMed PMID: 16713585.


Xu C, Call ME, Wucherpfennig KW. A membrane-proximal tetracysteine motif contributes to assembly of CD3deltaepsilon and CD3gammaepsilon dimers with the T cell receptor. J Biol Chem. 2006 Dec 1;281(48):36977-84. Epub 2006 Oct 5. PubMed PMID: 17023417.


Call ME, Schnell JR, Xu C, Lutz RA, Chou JJ, Wucherpfennig KW. The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor. Cell. 2006 Oct 20;127(2):355-68. PubMed PMID: 17055436.


Feng J, Call ME, Wucherpfennig KW. The assembly of diverse immune receptors is focused on a polar membrane-embedded interaction site. PLoS Biol. 2006 May;4(5):e142. Epub 2006 Apr 25. PubMed PMID: 16623599; PubMed Central PMCID: PMC1440944.


DiBacco A, Ouyang J, Lee HY, Catic A, Ploegh H, Gill G. The SUMO-specific protease SENP5 is required for cell division. Mol. Cell. Biol. 2006 Jun;26(12):4489-98.


Misaghi S, Balsara ZR, Catic A, Spooner E, Ploegh HL, Starnbach MN. Chlamydia trachomatis-derived deubiquitinating enzymes in mammalian cells during infection. Mol. Microbiol. 2006 Jul;61(1):142-150.


Artavanis-Tsakonas K, Misaghi S, Comeaux CA, Catic A, Spooner E, Duraisingh MT, Ploegh H. Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum. Mol. Microbiol. 2006 Sep;61(5):1187-95.


Ghosh S, Chackerian AA, Parker CM, Ballantyne CM, Behar SM. The LFA-1 adhesion molecule is required for protective immunity during pulmonary Mycobacterium tuberculosis infection. J Immunol. 2006 Apr 15;176(8):4914-22. PubMed PMID: 16585587.


Ma Y, Li J, Chiu I, Wang Y, Sloane JA, Lü J, Kosaras B, Sidman RL, Volpe JJ, Vartanian T. Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis. J Cell Biol. 2006 Oct 23;175(2):209-15. PMID: 17060494.


Zhang M, Alicot EM, Chiu I, Li J, Verna N, Vorup-Jensen T, Kessler B, Shimaoka M, Chan R, Friend D, Mahmood U, Weissleder R, Moore FD, Carroll MC. Identification of the target self-antigens in reperfusion injury. J Exp Med. 2006 Jan 23;203(1):141-52. Epub 2006 Jan 3. PMID: 16390934.


Yoshida M, Kobayashi K, Kuo TT, Bry L, Glickman JN, Claypool SM, Kaser A, Nagaishi T, Higgins DE, Mizoguchi E, Wakatsuki Y, Roopenian DC, Mizoguchi A, Lencer WI, and Blumberg RS. 2006. Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria. J. Clin. Invest. 2006 Aug;116(8): 2142-2151. PMCID: PMC1501111.


Yoshida M, Masuda A, Kuo TT, Kobayashi K, Claypool SM, Takagawa T, Kutsumi H, Azuma T, Lencer WI, Blumberg RS. IgG transport across mucosal barriers by neonatal Fc receptor for IgG and mucosal immunity. Springer Semin. Immunopathol. 2006 Dec; 28(4): 397-403. PMID: 17051393.


Ansel KM, Djuretic I, Tanasa B, Rao A. Regulation of Th2 differentiation and Il4 locus accessibility. Annu Rev Immunol. 2006;24:607-56. Review. PubMed PMID: 16551261.


Fragoso RC, Pyarajan S, Irie HY, Burakoff SJ. A CD8/Lck transgene is able to drive thymocyte differentiation. J Immunol, 177(9): 6007-17. 2006.


Koralov SB, Novobrantseva TI, Königsmann J, Ehlich A, Rajewsky K. Antibody repertoires generated by VH replacement and direct VH to JH joining. Immunity. 2006 Jul;25(1):43-53.


Casola S, Cattoretti G, Uyttersprot N, Koralov SB, Seagal J, Hao Z, Waisman A, Egert A, Ghitza D, Rajewsky K. Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7396-401. Epub 2006 May 1.


Keir ME, Liang SC, Guleria I, Latchman YE, Qipo A, Albacker LA, Koulmanda M, Freeman GJ, Sayegh MH, Sharpe AH. Tissue expression of PD-L1 mediates peripheral T cell tolerance. J Exp Med. 2006 Apr 17;203(4):883-95. Epub 2006 Apr 10. PubMed PMID: 16606670; PubMed Central PMCID: PMC2118286.


Liang SC, Greenwald RJ, Latchman YE, Rosas L, Satoskar A, Freeman GJ, Sharpe AH. PD-L1 and PD-L2 have distinct roles in regulating host immunity to cutaneous leishmaniasis. Eur J Immunol. 2006 Jan;36(1):58-64. PubMed PMID: 16358363.


Wang J, Fathman JW, Lugo-Villarino G, Scimone L, von Andrian U, Dorfman DM, Glimcher LH. Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells. J Clin Invest. 2006 Feb;116(2):414-21. Epub 2006 Jan 12. PubMed PMID: 16410834; PubMed Central PMCID: PMC1326147.


Rosas LE, Snider HM, Barbi J, Satoskar AA, Lugo-Villarino G, Keiser T, Papenfuss T, Durbin JE, Radzioch D, Glimcher LH, Satoskar AR. Cutting edge: STAT1 and T-bet play distinct roles in determining outcome of visceral leishmaniasis caused by Leishmania donovani. J Immunol. 2006 Jul 1;177(1):22-5. PubMed PMID: 16785492.


Borowski C, Martin C, Gounari F, Haughn L, Aifantis I, Grassi F, von Boehmer H. On the brink of becoming a T cell. Curr Opin Immunol. 2002 Apr;14(2):200 6. Review. PubMed PMID: 11869893.


Brigl M, van den Elzen P, Chen X, Meyers JH, Wu D, Wong CH, Reddington F, Illarianov PA, Besra GS, Brenner MB, Gumperz JE. Conserved and heterogeneous lipid antigen specificities of CD1d-restricted NKT cell receptors. J Immunol. 2006 Mar 15;176(6):3625-34. PubMed PMID: 16517731.


Kuchroo VK, Meyers JH, Umetsu DT, DeKruyff RH. TIM family of genes in immunity and tolerance. Adv Immunol. 2006;91:227-49. Review. PubMed PMID: 16938542.


Norris PJ, Stone JD, Anikeeva N, Heitman JW, Wilson IC, Hirschkorn DF, Clark MJ, Moffett HF, Cameron TO, Sykulev Y, Stern LJ, Walker BD. Antagonism of HIV-specific CD4+ T cells by C-terminal truncation of a minimum epitope. Mol Immunol. 2006 Mar;43(9):1349-57. Epub 2005 Oct 7. PubMed PMID: 16216327; PubMed Central PMCID: PMC2561961.


Moran ST, Cariappa A, Liu H, Boboila C, Shi HN, Holland PM, Peschon JJ, Pillai S. Protein kinase C-associated kinase is not required for the development of peripheral B lymphocyte populations. Mol Immunol. 2006. Apr;43(10):1694-9. PMID:16256200.


Yoshida T, Ng SY, Zuniga-Pflucker JC, Georgopoulos K. Early hematopoietic lineage restrictions directed by Ikaros. Nat Immunol. 2006 Apr;7(4):382-91. Epub 2006 Mar 5. PubMed PMID: 16518393.


Hovav AH, Cayabyab MJ, Panas MW, Santra S, Greenland J, Geiben R, Haynes BF, Jacobs WR Jr, Letvin NL.Rapid memory CD8+ T-lymphocyte induction through priming with recombinant Mycobacterium smegmatis. J Virol. 2007 Jan;81(1):74-83. Epub 2006 Oct 18. PMID:17050608. PMCID: PMC1797252.


Butty V, Roy M, Sabeti P, Besse W, Benoist C, Mathis D. Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes. Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):570-5. Epub 2006 Dec 29. PubMed PMID: 17197413; PubMed Central PMCID: PMC1766426.


Scimone ML, Aifantis I, Apostolou I, von Boehmer H, von Andrian UH. A multistep adhesion cascade for lymphoid progenitor cell homing to the thymus. Proc Natl Acad Sci U S A. 2006 May 2;103(18):7006-11. Epub 2006 Apr 25. PubMed PMID: 16641096; PubMed Central PMCID: PMC1459009.


Bonasio R, Scimone ML, Schaerli P, Grabie N, Lichtman AH, von Andrian UH. Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus. Nat Immunol. 2006 Oct;7(10):1092-100. Epub 2006 Sep 3. Erratum in: Nat Immunol. 2006 Nov;7(11):1234. PubMed PMID: 16951687.


Balsara ZR, Roan NR, Steele LN, Starnbach MN. Developmental regulation of Chlamydia trachomatis class I accessible protein-1, a CD8+ T cell antigen. J Infect Dis. 2006 May 15;193(10):1459-63. Epub 2006 Apr 12. PubMed PMID: 16619195.


Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, Lou Z, Bassing CH, Manis JP, Chen J, Carpenter PB, Alt FW. H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell. 2006 Jan 20;21(2):201-14. PubMed PMID: 16427010.


Yan CT, Kaushal D, Murphy M, Zhang Y, Datta A, Chen C, Monroe B, Mostoslavsky G, Coakley K, Gao Y, Mills KD, Fazeli AP, Tepsuporn S, Hall G, Mulligan R, Fox E, Bronson R, De Girolami U, Lee C, Alt FW. XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7378-83. Epub 2006 May 2. PubMed PMID: 16670198.


Jones DC*, Wein MN*, Oukka M, Hofstaetter J, Glimcher M, Glimcher LH. Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3. Science. 2006 May 26;312(5777):1223-7. PMID: 16728642


Lu L, Werneck MB, Cantor H. The immunoregulatory effects of Qa-1. Immunol Rev. 2006 Aug;212:51-9. Review. PubMed PMID: 16903905.


Shinohara ML, Lu L, Bu J, Werneck MB, Kobayashi KS, Glimcher LH, Cantor H. Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells. Nat Immunol. 2006 May;7(5):498-506. Epub 2006 Apr 9. PubMed PMID: 16604075.


Daniels R, Rusan NM, Wilbuer AK, Norkin LC, Wadsworth P, Hebert DN. Simian virus 40 late proteins possess lytic properties that render them capable of permeabilizing cellular membranes. J Virol. 2006 Jul;80(13):6575-87. PMID: 16775344 PMCID: PMC1488938


Kamath A, Woodworth JS, Behar SM. Antigen-specific CD8+ T cells and the development of central memory during Mycobacterium tuberculosis infection. J Immunol. 2006 Nov 1;177(9):6361-9. PubMed PMID: 17056567; PubMed Central PMCID: PMC3133654.


Woodworth JS, Behar SM. Mycobacterium tuberculosis-specific CD8+ T cells and their role in immunity. Crit Rev Immunol. 2006;26(4):317-52. Review. PubMed PMID: 17073557; PubMed Central PMCID: PMC3134450.


Zhang T, Sun Y, Tian E, Deng H, Zhang Y, Luo X, Cai Q, Wang H, Chai J, Zhang H. RNA-binding proteins SOP-2 and SOR-1 form a novel PcG-like complex in C.elegans. Development. 2006 Mar;133(6):1023-33.


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2005


Dougan SK, Salas A, Rava P, Agyemang A, Kaser A, Morrison J, Khurana A, Kronenberg M, Johnson C, Exley M, Hussain MM, Blumberg RS. Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells. J Exp Med. 2005 Aug 15;202(4):529-39. PMID: 16087713 PMCID: PMC2212858


Repik A, Pincus SE, Ghiran I, Nicholson-Weller A, Asher DR, Cerny AM, Casey LS, Jones SM, Jones SN, Mohamed N, Klickstein LB, Spitalny G, Finberg RW. A transgenic mouse model for studying the clearance of blood-borne pathogens via human complement receptor 1 (CR1). Clin Exp Immunol. (2005) 140:230-40.


Asher DR, Cerny AM, Weiler SR, Horner JW, Keeler ML, Neptune MA, Jones SN, Bronson RT, Depinho RA, Finberg RW. Coxsackievirus and adenovirus receptor is essential for cardiomyocyte development. Genesis (2005) 42:77-85.


Asher DR, Cerny AM, Finberg RW. The erythrocyte viral trap: transgenic expression of viral receptor on erythrocytes attenuates coxsackievirus B infection. Proc Natl Acad Sci U S A. (2005) 102:12897-902.


Kraft S, Fleming T, Billingsley JM, Lin SY, Jouvin MH, Storz P, Kinet JP. Anti-CD63 antibodies suppress IgE-dependent allergic reactions in vitro and in vivo. J Exp Med. 2005 Feb 7;201(3):385-96. Epub 2005 Jan 31. PubMed PMID: 15684326; PubMed Central PMCID: PMC2213034.


Gauguet JM, Bonasio R and von Andrian UH. High endothelial venules. In: Endothelial Cells in Health and Disease. (2005) Aird WC (ed.). Taylor & Francis, Boca Raton, FL. pp. 77-103.


Mazo IB, Honczarenko M, Leung H, Cavanagh LL, Bonasio R, Weninger W, Engelke K, Xia L, McEver RP, Koni PA, Silberstein LE, von Andrian UH (2005). Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells. Immunity 22:259-70. PMID: 15723813.


Halin C*, Scimone ML*, Bonasio R, Gauguet JM, Mempel TR, Quackenbush E, Proia RL, Mandala S, von Andrian UH (2005). The S1P-analog FTY720 differentially modulates T cell homing via HEV: T cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer's patches. Blood 106:1314-22. PMID: 15870184; PMCID: PMC1895188.


Cavanagh LL***, Bonasio R***, Mazo IB, Halin C, Cheng G, van der Velden AW, Cariappa A, Chase C, Russell P, Starnbach MN, Koni PA, Pillai S, Weninger W, von Andrian UH (2005). Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells. Nature Immunology 6:1029-37. PMID: 16155571; PMCID: PMC1780273.


Mandal M, Borowski C, Palomero T, Ferrando AA, Oberdoerffer P, Meng F, Ruiz-Vela A, Ciofani M, Zuniga-Pflucker JC, Screpanti I, Look AT, Korsmeyer SJ, Rajewsky K, von Boehmer H, Aifantis I. The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med. 2005 Feb 21;201(4):603-14.


Oberdoerffer P, Kanellopoulou C, Heissmeyer V, Paeper C, Borowski C, Aifantis I, Rao A, Rajewsky K. Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages. Mol Cell Biol. 2005 May;25(10):3896-905.


Ibrahim AS, Bowman JC, Avanessian V, Brown K, Spellberg B, Edwards JE Jr, Douglas CM. Caspofungin inhibits Rhizopus oryzae 1,3-beta-D-glucan synthase, lowers burden in brain measured by quantitative PCR, and improves survival at a low but not a high dose during murine disseminated zygomycosis. Antimicrob Agents Chemother. 2005 Feb;49(2):721-7. PubMed PMID: 15673756; PubMed Central PMCID: PMC547300.


Call ME, Wucherpfennig KW. The T cell receptor: critical role of the membrane environment in receptor assembly and function. Annu Rev Immunol. 2005;23:101-25. Review. PubMed PMID: 15771567.


Feng J, Garrity D, Call ME, Moffett H, Wucherpfennig KW. Convergence on a distinctive assembly mechanism by unrelated families of activating immune receptors. Immunity. 2005 Apr;22(4):427-38. PubMed PMID: 15845448.


O'Connor KC, Appel H, Bregoli L, Call ME, Catz I, Chan JA, Moore NH, Warren KG, Wong SJ, Hafler DA, Wucherpfennig KW. Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein. J Immunol. 2005 Aug 1;175(3):1974-82. PubMed PMID: 16034142.


Garrity D, Call ME, Feng J, Wucherpfennig KW. The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7641-6. Epub 2005 May 13. PubMed PMID: 15894612; PubMed Central PMCID: PMC1140444.


Catic A, Ploegh HL. Ubiquitin--conserved protein or selfish gene? Trends Biochem. Sci. 2005 Nov;30(11):600-4.


Clatworthy AE, Valencia-Burton MA, Haber JE, Oettinger MA. The MRE11-RAD50-XRS2 complex, in addition to other non-homologous end-joining factors, is required for V(D)J joining in yeast. J Biol Chem. 2005 May 27;280(21):20247-52. Epub 2005 Mar 9. PubMed PMID: 15757898.


Stirling CM, Charleston B, Takamatsu H, Claypool S, Lencer W, Blumberg RS, Wileman TE. Characterization of the porcine neonatal Fc receptor-potential use for trans-epithelial protein delivery. Immunology. 2005 Apr;114(4): 542-53. PMCID: PMC1782108.


Hua F, Cornejo MG, Cardone MH, Stokes CL, Lauffenburger DA. Effects of Bcl-2 levels on Fas signaling-induced caspase-3 activation: molecular genetic tests of computational model prediction. Journal of Immunology, 2005 Jul 15;175 (2):985-95.


Dougan SK, Salas A, Rava P, Agyemang A, Kaser A, Morrison J, Khurana A, Kronenberg M, Johnson C, Exley M, Hussain MM, Blumberg RS. Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells. J Exp Med. 2005 Aug 15;202(4):529-39. Epub 2005 Aug 8. PubMed PMID: 16087713; PubMed Central PMCID: PMC2212858.


Dudley DD, Chaudhuri J, Bassing CH, Alt FW. Mechanism and Control of V(D)J Recombination versus Class Switch Recombination: Similarities and Differences. Adv Immunol. 2005;86:43-112. PMID: 15705419.


van den Elzen P, Garg S, Leon L, Brigl M, Leadbetter EA, Gumperz JE, Dascher CC, Cheng TY, Sacks FM, Illarionov PA, Besra GS, Kent SC, Moody DB, Brenner MB. Apolipoprotein-mediated pathways of lipid antigen presentation. Nature. 2005 Oct 6;437(7060):906-10. PMID:16208376


Thompson MA, Stumph J, Henrickson SE, Rosenwald A, Wang Q, Olson S, Brandt SJ, Roberts J, Zhang X, Shyr Y, Kinney MC. Differential gene expression in anaplastic lymphoma kinase-positive and anaplastic lymphoma kinase-negative anaplastic large cell lymphomas. Hum Pathol. 2005 May;36(5):494-504. PMID: 15948116


Koralov SB, Novobrantseva TI, Hochedlinger K, Jaenisch R, Rajewsky K. Direct in vivo VH to JH rearrangement violating the 12/23 rule. J Exp Med. 2005. 7;201(3):341-8. PMCID: PMC1237122.


Monticelli S, Ansel KM, Lee DU, Rao A. Regulation of gene expression in mast cells: micro-rNA expression and chromatin structural analysis of cytokine genes. Novartis Found Symp. 2005;271:179-87; discussion 187-90, 198-9. Review. PubMed PMID: 16605135.


Monticelli S, Lee DU, Nardone J, Bolton DL, Rao A. Chromatin-based regulation of cytokine transcription in Th2 cells and mast cells. Int Immunol. 2005 Nov;17(11):1513-24. Epub 2005 Sep 30. PubMed PMID: 16199489.


van den Elzen P, Garg S, León L, Brigl M, Leadbetter EA, Gumperz JE, Dascher CC, Cheng TY, Sacks FM, Illarionov PA, Besra GS, Kent SC, Moody DB, Brenner MB. Apolipoprotein-mediated pathways of lipid antigen presentation. Nature. 2005 Oct 6;437(7060):906-10. PubMed PMID: 16208376.


Lugo-Villarino G, Ito S, Klinman DM, Glimcher LH. The adjuvant activity of CpG DNA requires T-bet expression in dendritic cells. Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13248-53. Epub 2005 Aug 31. PubMed PMID: 16135562; PubMed Central PMCID: PMC1201626.


Meyers JH, Chakravarti S, Schlesinger D, Illes Z, Waldner H, Umetsu SE, Kenny J, Zheng XX, Umetsu DT, DeKruyff RH, Strom TB, Kuchroo VK. TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation. Nat Immunol. 2005 May;6(5):455-64. Epub 2005 Mar 27. PubMed PMID: 15793576.


Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R,Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK. CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions. J Immunol. 2005 Aug 1;175(3):1558-65. PubMed PMID: 16034094.


Meyers JH, Sabatos CA, Chakravarti S, Kuchroo VK. The TIM gene family regulates autoimmune and allergic diseases. Trends Mol Med. 2005 Aug;11(8):362-9. Review. PubMed PMID: 16002337.


Pillai S, Cariappa A, Moran ST. Marginal zone B cells. Annu Rev Immunol. 2005. 23:161-96. PMID:15771569.


Paust S, Cantor H. Regulatory T cells and autoimmune disease. Immunol Rev. 2005 Apr;204:195-207. Review. PubMed PMID: 15790360.


Vincent MS, Xiong X, Grant EP, Peng W, Brenner MB. CD1a-, b-, and c-restricted TCRs recognize both self and foreign antigens. J Immunol. 2005 Nov 15;175(10):6344-51. PubMed PMID: 16272286.


Rooney S, Alt FW, Sekiguchi J, Manis JP. Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development. Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2471-5. Epub 2005 Feb 7. PMID: 15699324.


Zucchelli S, Holler P, Yamagata T, Roy M, Benoist C, Mathis D. Defective central tolerance induction in NOD mice: genomics and genetics. Immunity. 2005 Mar;22(3):385-96. PMID: 15780994.


Ohmura K, Johnsen A, Ortiz-Lopez A, Desany P, Roy M, Besse W, Rogus J, Bogue M, Puech A, Lathrop M, Mathis D, Benoist C. Variation in IL-1beta gene expression is a major determinant of genetic differences in arthritis aggressivity in mice. Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12489-94. Epub 2005 Aug 19. PubMed PMID: 16113081; PubMed Central PMCID: PMC1194932.


Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK. CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions. J Immunol. 2005 Aug 1;175(3):1558-65. PubMed PMID: 16034094.


Chakravarti S, Sabatos CA, Xiao S, Illes Z, Cha EK, Sobel RA, Zheng XX, Strom TB, Kuchroo VK. Tim-2 regulates T helper type 2 responses and autoimmunity. J Exp Med. 2005 Aug 1;202(3):437-44. Epub 2005 Jul 25. Erratum in: J Exp Med. 2005 Sep 19;202(6):877. PubMed PMID: 16043519; PubMed Central PMCID: PMC2213076.


Halin C, Scimone ML, Bonasio R, Gauguet JM, Mempel TR, Quackenbush E, Proia RL, Mandala S, von Andrian UH. The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches. Blood. 2005 Aug 15;106(4):1314-22. Epub 2005 May 3. PubMed PMID: 15870184; PubMed Central PMCID: PMC1895188.


Lord GM, Rao RM, Choe H, Sullivan BM, Lichtman AH, Luscinskas FW, Glimcher LH. T-bet is required for optimal pro-inflammatoy CD4+ T cell trafficking. Blood. 106(10):3432-9, 2005.


Sullivan BM***, Jobe O***, Lazarevic V***, Vasquez K, Bronson R, Glimcher LH, Kramnik Increased susceptibility of mice lacking T-bet to infection with Mycobacterium tuberculosis correlates with increased IL-10 and decreased IFN-gamma production. J. Immunol. 175(7):4593-602, 2005.


Borodovsky A, Ovaa H, Meester WJ, Venanzi ES, Bogyo MS, Hekking BG, Ploegh HL, Kessler BM, Overkleeft HS. Small-molecule inhibitors and probes for ubiquitin- and ubiquitin-like-specific proteases. Chembiochem. 2005 Feb;6(2):287-91. PubMed PMID: 15651044.


Johnnidis JB, Venanzi ES, Taxman DJ, Ting JP, Benoist CO, Mathis DJ. Chromosomal clustering of genes controlled by the aire transcription factor. Proc Natl Acad Sci U S A. 2005 May 17;102(20):7233-8. Epub 2005 May 9. PubMed PMID: 15883360; PubMed Central PMCID: PMC1129145.


Anderson MS, Venanzi ES, Chen Z, Berzins SP, Benoist C, Mathis D. The cellular mechanism of Aire control of T cell tolerance. Immunity. 2005 Aug;23(2):227-39. PubMed PMID: 16111640.


Villaseñor J, Benoist C, Mathis D. AIRE and APECED: molecular insights into an autoimmune disease. Immunol Rev. 2005 Apr;204:156-64. Review. PubMed PMID: 15790357.


Wein MN, Jones DC, Glimcher LH. Turning down the system: counter-regulatory mechanisms in bone and adaptive immunity. Immunol Rev. 2005 Dec;208:66-79. Review. PMID: 16313341


Shinohara ML, Jansson M, Hwang ES, Werneck MB, Glimcher LH, Cantor H.T-bet- dependent expression of osteopontin contributes to T cell polarization. Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17101-6. Epub 2005 Nov 14. PubMed PMID: 16286640; PubMed Central PMCID: PMC1288014.


ian T, Woodworth J, Sköld M, Behar SM. In vivo depletion of CD11c+ cells delays the CD4+ T cell response to Mycobacterium tuberculosis and exacerbates the outcome of infection. J Immunol. 2005 Sep 1;175(5):3268-72. PubMed PMID: 16116218.


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2004


Sklar PA, Agyemang AF, Monastra R, Kress DR, Metcalf JA, Robinson MR, Masur H, Polis MA.. Five-year follow-up of a cohort of profoundly immunosuppressed patients discontinuing therapy for cytomegalovirus retinitis. AIDS. 2004 Feb 20;18(3):567-9. PMID: 15090813


Arnett KL, Harrison SC, Wiley DC. Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment. Proc Natl Acad Sci U S A. 2004 Nov 16;101(46):16268-73. Epub 2004 Nov 8. PubMed PMID: 15534202; PubMed Central PMCID: PMC528977.


Steele LN, Balsara ZR, Starnbach MN. Hematopoietic cells are required to initiate a Chlamydia trachomatis-specific CD8+ T cell response. J Immunol. 2004 Nov 15;173(10):6327-37. PMID: 15528372.


On M, Billingsley JM, Jouvin MH, Kinet JP. Molecular dissection of the FcRbeta signaling amplifier. J Biol Chem. 2004 Oct 29;279(44):45782-90. Epub 2004 Aug 30. PubMed PMID: 15339926.


Repasky J, Corbett E, Boboila C, Schatz DG. Mutational analysis of terminal ofdeoxynucleotidyl transferase-mediated N-nucleotide addition in V(D)J recombination, J Immunol. 2004;172(9):5478-88. J Immunol. 2004;172(9):5478-88.


Borowski C, Li X, Aifantis I, Gounari F, von Boehmer H. Pre-TCRalpha and TCRalpha are not interchangeable partners of TCRbeta during T lymphocyte development. J Exp Med. 2004 Mar 1;199(5):607-15.


Call ME, Wucherpfennig KW. Molecular mechanisms for the assembly of the T cell receptor-CD3 complex. Mol Immunol. 2004 Apr;40(18):1295-305. Review. PubMed PMID: 15072848.


Call ME, Pyrdol J, Wucherpfennig KW. Stoichiometry of the T-cell receptor-CD3 complex and key intermediates assembled in the endoplasmic reticulum. EMBO J. 2004 Jun 16;23(12):2348-57. Epub 2004 May 20. PubMed PMID: 15152191; PubMed Central PMCID: PMC423287.


Deng LW, Chiu I, Strominger JL. MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression. Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):757-62. Epub 2004 Jan 12. PMID: 14718661.


Zhang M, Austen WG Jr, Chiu I, Alicot EM, Hung R, Ma M, Verna N, Xu M, Hechtman HB, Moore FD Jr, Carroll MC. Identification of a specific self-reactive IgM antibody that initiates intestinal ischemia/reperfusion injury. Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3886-91. Epub 2004 Mar 3. PMID: 14999103.


Ciccone DN, Morshead KB, Oettinger MA. Chromatin immunoprecipitation in the analysis of large chromatin domains across murine antigen receptor loci. Methods Enzymol. 2004;376:334-48. Review. PubMed PMID: 14975316.


Claypool SM, Dickinson BL, Wagner J, Johansen FE, Nanda Venu, Borawski J, Lencer WI, Blumberg RS. Bi-directional Transepithelial IgG Transport by a Strongly Polarized Basolateral Membrane Fcg-Receptor. Mol. Biol. Cell. 2004 Apr;15(4): 1746-59. PMCID: PMC379272.


Yoshida M, Claypool SM, Wagner JS, Mizoguchi E, Mizoguchi A, Roopenian DC, Lencer WI, Blumberg RS. Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells. Immunity. 2004 Jun;20(6): 769-83. PMID: 1518974.


Cooper EM, Hudson AW, Amos J, Wagstaff J, Howley PM. Biochemical analysis of Angelman syndrome-associated mutations in the E3 ubiquitin ligase E6-associated protein. J Biol Chem. 2004 Sep 24;279(39):41208-17. Epub 2004 Jul 19. PubMed PMID: 15263005.


Cortés M, Georgopoulos K. Aiolos is required for the generation of high affinity bone marrow plasma cells responsible for long-term immunity. J Exp Med. 2004 Jan 19;199(2):209-19. Epub 2004 Jan 12. PubMed PMID: 14718515; PubMed Central PMCID: PMC2211773.


Ansel KM, Greenwald RJ, Agarwal S, Bassing CH, Monticelli S, Interlandi J, Djuretic IM, Lee DU, Sharpe AH, Alt FW, Rao A. Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat Immunol. 2004 Dec;5(12):1251-9. Epub 2004 Oct 31. PubMed PMID: 15516924.


Talukder SR, Dudley DD, Alt FW, Takahama Y, Akamatsu Y. Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice. Nucleic Acids Res. 2004 Aug 24;32(15):4539-49. Print 2004. PMID: 15328366.


Mempel TR, Henrickson SE, Von Andrian UH. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature. 2004 Jan 8;427(6970):154-9. PMID: 14712275


Cahir-McFarland ED, Carter K, Rosenwald A, Giltnane JM, Henrickson SE, Staudt LM, Kieff E. Role of NF-kappa B in cell survival and transcription of latent membrane protein 1-expressing or Epstein-Barr virus latency III-infected cells. J Virol. 2004 Apr;78(8):4108-19. PMID: 15047827 PMCID: PMC374271


Andres PG, Howland KC, Nirula A, Kane LP, Barron L, Dresnek D, Sadra A, Imboden J, Weiss A, Abbas AK. Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation. Nat Immunol. 2004 Apr;5(4):435-42. Epub 2004 Mar 7.


Andres PG, Howland KC, Dresnek D, Edmondson S, Abbas AK, Krummel MF. CD28 signals in the immature immunological synapse. J Immunol. 2004 May 15;172(10):5880-6.


Nardone J, Lee DU, Ansel KM, Rao A. Bioinformatics for the 'bench biologist': how to find regulatory regions in genomic DNA. Nat Immunol. 2004 Aug;5(8):768-74. Review. PubMed PMID: 15282556.


Lee DU, Rao A. Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: a target for STAT6 but not GATA3. Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):16010-5. Epub 2004 Oct 26. PubMed PMID: 15507491; PubMed Central PMCID: PMC528768.


Ansel KM, Greenwald RJ, Agarwal S, Bassing CH, Monticelli S, Interlandi J, Djuretic IM, Lee DU, Sharpe AH, Alt FW, Rao A. Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat Immunol. 2004 Dec;5(12):1251-9. Epub 2004 Oct 31. PubMed PMID: 15516924.


Matthews AG, Elkin SK, Oettinger MA. Ordered DNA release and target capture in RAG transposition. EMBO J. 2004 Mar 10;23(5):1198-206. Epub 2004 Feb 26. PubMed PMID: 14988730; PubMed Central PMCID: PMC380985.


Norris PJ, Moffett HF, Brander C, Allen TM, O'Sullivan KM, Cosimi LA, Kaufmann DE, Walker BD, Rosenberg ES. Fine specificity and cross-clade reactivity of HIV type 1 Gag-specific CD4+ T cells. AIDS Res Hum Retroviruses. 2004 Mar;20(3):315-25. PMID: 15117455.


SenGupta D, Norris PJ, Suscovich TJ, Hassan-Zahraee M, Moffett HF, Trocha A, Draenert R, Goulder PJ, Binder RJ, Levey DL, Walker BD, Srivastava PK, Brander C. Heat shock protein-mediated cross-presentation of exogenous HIV antigen on HLA class I and class II. J Immunol. 2004 Aug 1;173(3):1987-93. PMID: 15265933


Norris PJ, Moffett HF, Yang OO, Kaufmann DE, Clark MJ, Addo MM, Rosenberg ES. Beyond help: direct effector functions of human immunodeficiency virus type 1-specific CD4(+) T cells. J Virol. 2004 Aug;78(16):8844-51. PMID: 15280492


Pillai S, Cariappa A, Moran ST. Positive selection and lineage commitment during peripheral B-lymphocyte development. Immunol Rev. 2004. Feb;197:206-18. PMID:14962197.


Ciccone DN, Morshead KB, Oettinger MA. Chromatin immunoprecipitation in the analysis of large chromatin domains across murine antigen receptor loci. Methods Enzymol. 2004;376:334-48. Review. PubMed PMID: 14975316.


On M, Billingsley JM, Jouvin MH, Kinet JP. Molecular dissection of the FcRbeta signaling amplifier. J Biol Chem. 2004 Oct 29;279(44):45782-90. Epub 2004 Aug 30. PubMed PMID: 15339926.


Paust S, Lu L, McCarty N, Cantor H. Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease. Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10398-403. Epub 2004 Jul 2. PubMed PMID: 15235129; PubMed Central PMCID: PMC478583.


McCarty N, Paust S, Ikizawa K, Dan I, Li X, Cantor H. Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes. Nat Immunol. 2005 Jan;6(1):65-72. Epub 2004 Dec 19. Erratum in: Nat Immunol. 2005 Feb;6(2):219. PubMed PMID: 15608642.


Radosevich M, Song Z, Gorga JC, Ksander B, Ono SJ. Epigenetic silencing of the CIITA gene and posttranscriptional regulation of class II MHC genes in ocular melanoma cells. Invest Ophthalmol Vis Sci. 2004 Sep;45(9):3185-95. PMID: 15326139


Radosevich M, Ono SJ. MHC class II gene expression is not induced in HPIV3-infected respiratory epithelial cells. Immunol Res. 2004;30(2):125-38. PMID: 15477655.


Kraft S, Rana S, Jouvin MH, Kinet JP. The role of the FcepsilonRI beta-chain in allergic diseases. Int Arch Allergy Immunol. 2004 Sep;135(1):62-72. Epub 2004 Aug 13. Review. PMID: 15316148.


Ghosh AK, Reddi AL, Rao NL, Duan L, Band V, Band H. Biochemical basis for the requirement of kinase activity for Cbl-dependent ubiquitinylation and degradation of a target tyrosine kinase. J Biol Chem. 2004 Aug 20;279(34):36132-41. Epub 2004 Jun 18. PubMed PMID: 15208330.


Rooney S, Sekiguchi J, Whitlow S, Eckersdorff M, Manis JP, Lee C, Ferguson DO, Alt FW. Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells. Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2410-5. PMID: 14983023.


Rooney S, Chaudhuri J, Alt FW. The role of the non-homologous end-joining pathway in lymphocyte development. Immunol Rev. 2004 Aug;200:115-31. Review. PMID: 15242400.


Scimone ML, Felbinger TW, Mazo IB, Stein JV, Von Andrian UH, Weninger W. CXCL12 mediates CCR7-independent homing of central memory cells, but not naive T cells, in peripheral lymph nodes. J Exp Med. 2004 Apr 19;199(8):1113-20. PubMed PMID: 15096537; PubMed Central PMCID: PMC2211897.


Monticelli S, Solymar DC, Rao A. Role of NFAT proteins in IL13 gene transcription in mast cells. J Biol Chem. 2004 Aug 27;279(35):36210-8. Epub 2004 Jun 30. PMID: 15229217.


Steele LN, Balsara ZR, Starnbach MN. Hematopoietic cells are required to initiate a Chlamydia trachomatis-specific CD8+ T cell response. J Immunol. 2004 Nov 15;173(10):6327-37. PubMed PMID: 15528372.


Su MW, Pyarajan S, Chang JH, Yu CL, Jin YJ, Stierhof YD, Walden P, Burakoff SJ. Fratricide of CD8+ cytotoxic T lymphocytes is dependent on cellular activation and perforin-mediated killing. Eur J Immunol. 2004 Sep;34(9):2459-70. PMID: 15307178.


Bettelli E, Sullivan B, Szabo SJ, Sobel RA, Glimcher LH, Kuchroo VK. Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J. Exp. Med. 200(1):79-87, 2004.


INVITED PUBLICATIONS (non-peer reviewed): Glimcher LH, Townsend MJ, Sullivan BM, Lord GM. Recent developments in the transcriptional regulation of cytolytic effector cells. Nat. Rev. Immunol. 4(11):900-11, 2004.


Venanzi ES, Benoist C, Mathis D. Good riddance: Thymocyte clonal deletion prevents autoimmunity. Curr Opin Immunol. 2004 Apr;16(2):197-202. PubMed PMID: 15023413.


Oukka M, Wein MN, Glimcher LH. Schnurri-3 (KRC) Interacts with c-Jun to Regulate the IL-2 Gene in T Cells. J Exp Med. 2004 Jan 5;199(1):15-24.PMID: 14707112 PMCID: PMC1887724


Kamath AB, Woodworth J, Xiong X, Taylor C, Weng Y, Behar SM. Cytolytic CD8+ T cells recognizing CFP10 are recruited to the lung after Mycobacterium tuberculosis infection. J Exp Med. 2004 Dec 6;200(11):1479-89. Epub 2004 Nov 22. PubMed PMID: 15557351; PubMed Central PMCID: PMC2211947.


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2003


Schott E, Bonasio R, Ploegh HL (2003). Elimination in vivo of developing T cells by natural killer cells. Journal of Experimental Medicine 198:1213-24. PMID: 14568980; PMCID: PMC2194238.


Sicinska E, Aifantis I, Le Cam L, Swat W, Borowski C, Yu Q, Ferrando AA, Levin SD, Geng Y, von Boehmer H, Sicinski P. Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell. 2003 Dec;4(6):451-61.


Mitra RD, Butty VL, Shendure J, Williams BR, Housman DE, Church GM. Digital genotyping and haplotyping with polymerase colonies. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5926-31. Epub 2003 May 2. PMID: 12730373.


Butty VL, Roux-Lombard P, Garbino J, Dayer JM, Ricou B; Geneva Sepsis Network. Anti-inflammatory response after infusion of p55 soluble tumor necrosis factor receptor fusion protein for severe sepsis. Eur Cytokine Netw. 2003 Jan-Mar;14(1):15-9. PMID:12799209.


Traver D, Herbomel P, Patton EE, Murphey RD, Yoder JA, Litman GW, Catic A, Amemiya CT, Zon LI, Trede NS. The zebrafish as a model organism to study development of the immune system. Adv. Immunol. 2003;81:253-330. Review.


Ng HH, Ciccone DN, Morshead KB, Oettinger MA, Struhl K. Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegation. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1820-5. Epub 2003 Feb 6. PubMed PMID: 12574507; PubMed Central PMCID: PMC149917.


Morshead KB, Ciccone DN, Taverna SD, Allis CD, Oettinger MA. Antigen receptor loci poised for V(D)J rearrangement are broadly associated with BRG1 and flanked by peaks of histone H3 dimethylated at lysine 4. Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11577-82. Epub 2003 Sep 19. PubMed PMID: 14500909; PubMed Central PMCID: PMC208800.


Clatworthy AE, Valencia MA, Haber JE, Oettinger MA. V(D)J recombination and RAG-mediated transposition in yeast. Mol Cell. 2003 Aug;12(2):489-99. PubMed PMID: 14536087.


Subbramanian RA, Kuroda MJ, Charini WA, Barouch DH, Costantino C, Santra S, Schmitz JE, Martin KL, Lifton MA, Gorgone DA, Shiver JW, Letvin NL. Magnitude and diversity of cytotoxic-T-lymphocyte responses elicited by multiepitope DNA vaccination in rhesus monkeys. J Virol. 2003 Sep;77(18):10113-8. PubMed PMID: 12941922; PubMed Central PMCID: PMC224609.


Zhou P, Fernandes N, Dodge IL, Reddi AL, Rao N, Safran H, DiPetrillo TA, Wazer DE, Band V, Band H. ErbB2 degradation mediated by the co-chaperone protein CHIP. J Biol Chem. 2003 Apr 18;278(16):13829-37. Epub 2003 Feb 6. PubMed PMID:12574167.


Dodge IL, Carr MW, Cernadas M, Brenner MB. IL-6 production by pulmonary dendritic cells impedes Th1 immune responses. J Immunol. 2003 May 1;170(9):4457-64. PubMed PMID: 12707321.


Duan L, Miura Y, Dimri M, Majumder B, Dodge IL, Reddi AL, Ghosh A, Fernandes N, Zhou P, Mullane-Robinson K, Rao N, Donoghue S, Rogers RA, Bowtell D, Naramura M, Gu H, Band V, Band H. Cbl-mediated ubiquitinylation is required for lysosomal sorting of epidermal growth factor receptor but is dispensable for endocytosis. J Biol Chem. 2003 Aug 1;278(31):28950-60. Epub 2003 May 18. PubMed PMID: 12754251.


Akamatsu Y, Monroe R, Dudley DD, Elkin SK, Gartner F, Talukder SR, Takahama Y, Alt FW, Bassing CH, Oettinger MA. Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1209-14. Epub 2003 Jan 16. PMID: 12531919.


Dudley DD, Sekiguchi J, Zhu C, Sadofsky MJ, Whitlow S, DeVido J, Monroe RJ, Bassing CH, Alt FW. Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice. J Exp Med. 2003 Nov 3;198(9):1439-50. Epub 2003 Oct 27. PMID: 14581608.


Fragoso R, Ren D, Zhang X, Su MW, Burakoff SJ, Jin YJ. Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling. J Immunol, 170(2):913-21. 2003.


Furman MH, Loureiro J, Ploegh HL, Tortorella D. Ubiquitinylation of the cytosolic domain of a type I membrane protein is not required to initiate its dislocation from the endoplasmic reticulum. J Biol Chem. 2003 Sep 12;278(37):34804-11. Epub 2003 Jun 27. PubMed PMID: 12832421.


Tirosh B, Furman MH, Tortorella D, Ploegh HL. Protein unfolding is not a prerequisite for endoplasmic reticulum-to-cytosol dislocation. J Biol Chem. 2003 Feb 28;278(9):6664-72. Epub 2002 Dec 12. PubMed PMID: 12482753.


Kaufmann C, Yoshida T, Perotti EA, Landhuis E, Wu P, Georgopoulos K. A complex network of regulatory elements in Ikaros and their activity during hemo-lymphopoiesis. EMBO J. 2003 May 1;22(9):2211-23. PubMed PMID: 12727887; PubMed Central PMCID: PMC156063.


Ansel KM, Lee DU, Rao A. An epigenetic view of helper T cell differentiation. Nat Immunol. 2003 Jul;4(7):616-23. Review. PubMed PMID: 12830136.


Lee DU, Avni O, Chen L, Rao A. A distal enhancer in the interferon-gamma (IFN-gamma) locus revealed by genome sequence comparison. J Biol Chem. 2004 Feb 6;279(6):4802-10. Epub 2003 Nov 8. PubMed PMID: 14607827.


Kircher MF, Allport JR, Graves EE, Love V, Josephson L, Lichtman AH, Weissleder R. In vivo high resolution three-dimensional imaging of antigen-specific cytotoxic T-lymphocyte trafficking to tumors. Cancer Res. 2003 Oct 15;63(20):6838-46.


Grabie N, Delfs MW, Westrich JR, Love VA, Stavrakis G, Ahmad F, Seidman CE, Seidman JG, Lichtman AH. IL-12 is required for differentiation of pathogenic CD8+ T cell effectors that cause myocarditis. J Clin Invest. 2003 Mar;111(5):671-80. PubMed PMID: 12618521; PubMed Central PMCID: PMC151896.


Lugo-Villarino G, Maldonado-Lopez R, Possemato R, Penaranda C, Glimcher LH. T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7749-54. Epub 2003 Jun 11. PubMed PMID: 12802010; PubMed Central PMCID: PMC164659.


Martin CH, Aifantis I, Scimone ML, von Andrian UH, Reizis B, von Boehmer H, Gounari F. Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential. Nat Immunol. 2003 Sep;4(9):866-73. Epub 2003 Aug 17. PubMed PMID: 12925850.


Elkin SK, Matthews AG, Oettinger MA. The C-terminal portion of RAG2 protects against transposition in vitro. EMBO J. 2003 Apr 15;22(8):1931-8. PubMed PMID: 12682025; PubMed Central PMCID: PMC154476.


Montalbano A, Ogwaro KM, Tang A, Matthews AG, Larijani M, Oettinger MA, Feeney AJ. V(D)J recombination frequencies can be profoundly affected by changes in the spacer sequence. J Immunol. 2003 Nov 15;171(10):5296-304. PubMed PMID: 14607931.


Moran ST, Haider K, Ow Y, Milton P, Chen L, Pillai S. Protein kinase C-associated kinase can activate NFkappaB in both a kinase-dependent and a kinase-independent manner. J Biol Chem. 2003. Jun 13;278(24):21526-33. PMID:12676934.


Cariappa A, Chen L, Haider K, Tang M, Nebelitskiy E, Moran ST, Pillai S. A catalytically inactive form of protein kinase C-associated kinase/receptor interacting protein 4, a protein kinase C beta-associated kinase that mediates NF-kappa B activation, interferes with early B cell development. J Immunol. 2003. Aug 15;171(4):1875-80. PMID:12902489.


Ng HH, Ciccone DN, Morshead KB, Oettinger MA, Struhl K. Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegation. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1820-5. Epub 2003 Feb 6. PubMed PMID: 12574507; PubMed Central PMCID: PMC149917.


Morshead KB, Ciccone DN, Taverna SD, Allis CD, Oettinger MA. Antigen receptor loci poised for V(D)J rearrangement are broadly associated with BRG1 and flanked by peaks of histone H3 dimethylated at lysine 4. Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11577-82. Epub 2003 Sep 19. PubMed PMID: 14500909; PubMed Central PMCID: PMC208800.


Radosevich M, Ono SJ. Novel mechanisms of class II major histocompatibility complex gene regulation. Immunol Res. 2003;27(1):85-106. Review. PMID: 12637770.


Donnadieu E, Jouvin MH, Rana S, Moffatt MF, Mockford EH, Cookson WO, Kinet JP. Competing functions encoded in the allergy-associated F(c)epsilon RI beta gene. Immunity. 2003 May;18(5):665-74. PMID: 12753743.


Miura-Shimura Y, Duan L, Rao NL, Reddi AL, Shimura H, Rottapel R, Druker BJ, Tsygankov A, Band V, Band H. Cbl-mediated ubiquitinylation and negative regulation of Vav. J Biol Chem. 2003 Oct 3;278(40):38495-504. Epub 2003 Jul 24. PubMed PMID: 12881521.


Rooney S, Alt FW, Lombard D, Whitlow S, Eckersdorff M, Fleming J, Fugmann S, Ferguson DO, Schatz DG, Sekiguchi J. Defective DNA repair and increased genomic instability in Artemis-deficient murine cells. J Exp Med. 2003 Mar 3;197(5):553-65. PMID: 12615897.


Sánchez-Fueyo A, Tian J, Picarella D, Domenig C, Zheng XX, Sabatos CA, Manlongat N, Bender O, Kamradt T, Kuchroo VK, Gutiérrez-Ramos JC, Coyle AJ, Strom TB. Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat Immunol. 2003 Nov;4(11):1093-101. Epub 2003 Oct 12. PubMed PMID: 14556005.


Sabatos CA, Chakravarti S, Cha E, Schubart A, Sánchez-Fueyo A, Zheng XX, Coyle AJ, Strom TB, Freeman GJ, Kuchroo VK. Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat Immunol. 2003 Nov;4(11):1102-10. Epub 2003 Oct 12. PubMed PMID: 14556006.


Martin CH, Aifantis I, Scimone ML, von Andrian UH, Reizis B, von Boehmer H, Gounari F. Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential. Nat Immunol. 2003 Sep;4(9):866-73. Epub 2003 Aug 17. PubMed PMID: 12925850.


Fragoso R, Ren D, Zhang X, Su MW, Burakoff SJ, Jin YJ. Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling. J Immunol. 2003 Jan 15;170(2):913-21. PMID: 12517957.


Sullivan BM, Juedes A, Szabo SJ, von Herrath M, Glimcher LH. Antigen-driven effector CD8 T cell function regulated by T-bet. PNAS 100(26):15818-23, 2003.


INVITED PUBLICATIONS (non-peer reviewed): Szabo SJ, Sullivan BM, Peng SL, Glimcher LH. Molecular mechanisms regulating Th1 immune responses. Annnu. Rev. Immunol. 21:713-58, 2003.


Field SJ, Madson N, Kerr M, Galbraith K, Kennedy C, Tahiliani M, Cantley L. Functions at the Cleavage Furrow During Cytokinesis. Current Biology (2003) 15 (15): 1407-12.


Berzins SP, Venanzi ES, Benoist C, Mathis D. T-cell compartments of prediabetic NOD mice. Diabetes. 2003 Feb;52(2):327-34. PubMed PMID: 12540604.


Gozani O, Karuman P, Jones DR, Ivanov D, Cha J, Lugovskoy AA, Baird CL, Zhu H, Field SJ, Lessnick SL, Villasenor J, Mehrotra B, Chen J, Rao VR, Brugge JS, Ferguson CG, Payrastre B, Myszka DG, Cantley LC, Wagner G, Divecha N, Prestwich GD, Yuan J. The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell. 2003 Jul 11;114(1):99-111. PubMed PMID: 12859901.


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2002


Borowski C, Martin C, Gounari F, Haughn L, Aifantis I, Grassi F, von Boehmer H. On the brink of becoming a T cell. Curr Opin Immunol. 2002 Apr;14(2):200-6. Review.


Aifantis I, Borowski C, Gounari F, Lacorazza HD, Nikolich-Zugich J, von Boehmer H. A critical role for the cytoplasmic tail of pTalpha in T lymphocyte development. Nat Immunol. 2002 May;3(5):483-8.


Call ME, Pyrdol J, Wiedmann M, Wucherpfennig KW. The organizing principle in the formation of the T cell receptor-CD3 complex. Cell. 2002 Dec 27;111(7):967-79. PubMed PMID: 12507424.


Chackerian AA, Alt JM, Perera TV, Dascher CC, Behar SM. Dissemination of Mycobacterium tuberculosis is influenced by host factors and precedes the initiation of T-cell immunity. Infect Immun. 2002 Aug;70(8):4501-9. PubMed PMID: 12117962; PubMed Central PMCID: PMC128141.


Chackerian A, Alt J, Perera V, Behar SM. Activation of NKT cells protects mice from tuberculosis. Infect Immun. 2002 Nov;70(11):6302-9. PubMed PMID: 12379709; PubMed Central PMCID: PMC130331.


Bassing CH, Chua KF, Sekiguchi J, Suh H, Whitlow SR, Fleming JC, Monroe BC, Ciccone DN, Yan C, Vlasakova K, Livingston DM, Ferguson DO, Scully R, Alt FW. Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8173-8. Epub 2002 May 28. PubMed PMID: 12034884; PubMed Central PMCID: PMC123040.


Claypool SM, Dickinson BL, Yoshida M, Lencer WI, Blumberg RS. Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin. J. Biol. Chem. 2002 Aug 2; 277(31):28038-50. PMID: 12023961.


Harker N, Naito T, Cortes M, Hostert A, Hirschberg S, Tolaini M, Roderick K, Georgopoulos K, Kioussis D. The CD8alpha gene locus is regulated by the Ikaros family of proteins. Mol Cell. 2002 Dec;10(6):1403-15. PubMed PMID: 12504015.


Desai BN, Myers BR, Schreiber SL. FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4319-24. PubMed PMID: 11930000; PubMed Central PMCID: PMC123646.


Rao N, Miyake S, Reddi AL, Douillard P, Ghosh AK, Dodge IL, Zhou P, Fernandes ND, Band H. Negative regulation of Lck by Cbl ubiquitin ligase. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3794-9. PubMed PMID: 11904433; PubMed Central PMCID: PMC122603.


Rao N, Dodge I, Band H. The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune system. J Leukoc Biol. 2002 May;71(5):753-63. Review. PubMed PMID: 11994499.


Dascher CC, Hiromatsu K, Xiong X, Sugita M, Buhlmann JE, Dodge IL, Lee SY, Roura-Mir C, Watts GF, Roy CJ, Behar SM, Clemens DL, Porcelli SA, Brenner MB. Conservation of CD1 intracellular trafficking patterns between mammalian species. J Immunol. 2002 Dec 15;169(12):6951-8. PubMed PMID: 12471129.


Dudley DD, Manis JP, Zarrin AA, Kaylor L, Tian M, Alt FW. Internal IgH class switch region deletions are position-independent and enhanced by AID expression. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9984-9. Epub 2002 Jul 11. PMID: 12114543.


Halamay KE, Kirkman RL, Sun L, Yamada A, Fragoso RC, Shimizu K, Mitchell RN, McKay DB. CD8 T cells are sufficient to mediate allorecognition and allograft rejection. Cell Immunol, 216(1-2): 6-14. 2002.


Furman MH, Ploegh HL. Lessons from viral manipulation of protein disposal pathways. J Clin Invest. 2002 Oct;110(7):875-9. Review. PubMed PMID: 12370262; PubMed Central PMCID: PMC151163.


Furman MH, Dey N, Tortorella D, Ploegh HL. The human cytomegalovirus US10 gene product delays trafficking of major histocompatibility complex class I molecules. J Virol. 2002 Nov;76(22):11753-6. PubMed PMID: 12388737; PubMed Central PMCID: PMC136774.


Vugmeyster Y, Borodovsky A, Maurice MM, Maehr R, Furman MH, Ploegh HL. The ubiquitin-proteasome pathway in thymocyte apoptosis: caspase-dependent processing of the deubiquitinating enzyme USP7 (HAUSP). Mol Immunol. 2002 Nov;39(7-8):431-41. PubMed PMID: 12413694.


Gewurz, BE, Ploegh, HL, Tortorella, D. US2, a Human Cytomegalovirus-Encoded Type I Membrane Protein, Contains a Non-cleavable Amino-terminal Signal Peptide. J. Biological Chemistry. 2002 277(13): 11306-13. PMID: 11790769.


Lee DU, Agarwal S, Rao A. Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene. Immunity. 2002 May;16(5):649-60. PubMed PMID: 12049717.


Avni O, Lee D, Macian F, Szabo SJ, Glimcher LH, Rao A. T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat Immunol. 2002 Jul;3(7):643-51. Epub 2002 Jun 10. PubMed PMID: 12055628.


Gounari F, Aifantis I, Martin C, Fehling HJ, Hoeflinger S, Leder P, von Boehmer H, Reizis B. Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene. Nat Immunol. 2002 May;3(5):489-96. Epub 2002 Apr 1. PubMed PMID: 11927910.


Mundy CL, Patenge N, Matthews AG, Oettinger MA. Assembly of the RAG1/RAG2 synaptic complex. Mol Cell Biol. 2002 Jan;22(1):69-77. PubMed PMID: 11739723; PubMed Central PMCID: PMC134220.


Meyers JH, Ryu A, Monney L, Nguyen K, Greenfield EA, Freeman GJ, Kuchroo VK. Cutting edge: CD94/NKG2 is expressed on Th1 but not Th2 cells and costimulates Th1 effector functions. J Immunol. 2002 Nov 15;169(10):5382-6. PubMed PMID: 12421909.


Pillai S, Moran ST. Tec kinase pathways in lymphocyte development and transformation. Biochim Biophys Acta. 2002 Jun 21;1602(2):162-7. PMID:12020802.


Rooney S, Sekiguchi J, Zhu C, Cheng HL, Manis J, Whitlow S, DeVido J, Foy D, Chaudhuri J, Lombard D, Alt FW. Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice. Mol Cell. 2002 Dec;10(6):1379-90. PMID: 12504013.


Monney L, Sabatos CA, Gaglia JL, Ryu A, Waldner H, Chernova T, Manning S,Greenfield EA, Coyle AJ, Sobel RA, Freeman GJ, Kuchroo VK. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature. 2002 Jan 31;415(6871):536-41. PubMed PMID: 11823861.


Solymar DC, Agarwal S, Bassing CH, Alt FW, Rao A. A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells. Immunity. 2002 Jul;17(1):41-50. PMID: 12150890.


Neurath MF, Weigmann B, Finotto S, Glickman J, Nieuwenhuis E, Iijima H, Mizoguchi A, Mizoguchi E, Mudter J, Galle PR, Bhan A, Autschbach F, Sullivan BM, Szabo SJ, Glimcher LH, Blumberg RS. The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease. J Exp Med. 2002 May 6;195(9):1129-43. Erratum in: J Exp Med 2002 Jun 3;195(11):1513. PubMed PMID: 11994418; PubMed Central PMCID: PMC2193714.


Szabo SJ, Sullivan BM, Stemmann C, Satoskar AR, Sleckman BP, Glimcher LH. Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 295(5553):338-42, 2002.


Hoyer KK, French SW, Turner DE, Nguyen MT, Renard M, Malone CS, Knoetig S, Qi CF, Su TT, Cheroutre H, Wall R, Rawlings DJ, Morse HC 3rd, Teitell MA. Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14392-7. Epub 2002 Oct 14. PubMed PMID: 12381789; PubMed Central PMCID: PMC137894.


Anderson MS, Venanzi ES, Klein L, Chen Z, Berzins SP, Turley SJ, von Boehmer H, Bronson R, Dierich A, Benoist C, Mathis D. Projection of an immunological self shadow within the thymus by the aire protein. Science. 2002 Nov 15;298(5597):1395-401. Epub 2002 Oct 10. PubMed PMID: 12376594.


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2001


Chackerian AA, Perera TV, Behar SM. Gamma interferon-producing CD4+ T lymphocytes in the lung correlate with resistance to infection with Mycobacterium tuberculosis. Infect Immun. 2001 Apr;69(4):2666-74. PubMed PMID: 11254633; PubMed Central PMCID: PMC98205.


Ranganathan V, Heine WF, Ciccone DN, Rudolph KL, Wu X, Chang S, Hai H, Ahearn IM, Livingston DM, Resnick I, Rosen F, Seemanova E, Jarolim P, DePinho RA, Weaver DT. Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit. Curr Biol. 2001 Jun 26;11(12):962-6. PubMed PMID: 11448772.


Blumberg RS, van de Wal Y, Claypool S, Corazza N, Dickinson B, Nieuwenhuis E, Pitman R, Spiekermann G, Zhu X, Colgan S, Lencer WI. The multiple roles of major histocompatibility complex class-I-like molecules in mucosal immune function. Acta Odontol. Scand. 2001 Jun; 59(3): 139-44. PMID: 11501882.


Kelley, C., Koipally, J., Cortés, M. and Georgopoulos, K. 2001. Role of Ikaros Proteins in Lymphocyte Development and Function. In: Hematopoiesis, A Developmental Approach, Leonard I. Zon, ed. (Oxford University Press New York, NY).


Nghiem P, Park PK, Kim Ys YS, Desai BN, Schreiber SL. ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint. J BiolChem. 2002 Feb 8;277(6):4428-34. Epub 2001 Nov 15. PubMed PMID: 11711532.


Wong DK, Dudley DD, Dohrenwend PB, Lauer GM, Chung RT, Thomas DL, Walker BD. Detection of diverse hepatitis C virus (HCV)-specific cytotoxic T lymphocytes in peripheral blood of infected persons by screening for responses to all translated proteins of HCV. J Virol. 2001 Feb;75(3):1229-35. PMID: 11152496.


Furman MH, Ploegh HL, Tortorella D. Membrane-specific, host-derived factors are required for US2- and US11-mediated degradation of major histocompatibility complex class I molecules. J Biol Chem. 2002 Feb 1;277(5):3258-67. Epub 2001 Nov 20. PubMed PMID: 11717308.


Gewurz, BE, Wang, EW, Tortorella, D, Schust, DJ, Ploegh, HL. The Human Cytomegalovirus US2 Endoplasmic Reticulum-lumenal Domain Dictates Association with Major Histocompatibility Complex Class I in a Locus-specific Manner. J. Virology. 2001 75(11): 5197-204. PMID: 11333901.


Gewurz, BE, Gaudet, R, Tortorella, D, Wang, EW, Ploegh, HL. Virus Immune-evasion: a Structural Perspective. Current Opinion in Immunology. 2001 13(4):442-50. PMID 11498300.


Gewurz, BE, Gaudet, R, Tortorella, D, Wang, EW, Ploegh, HL, Wiley, DC. Antigen Presentation Subverted: Structure of the Human Cytomegalovirus Protein US2 Bound to the Class I Molecule HLA-A2. Proc Natl Acad Sci USA. 2001 98(12): 6794-6799. PMID: 11391001.


Kane LP, Andres PG, Howland KC, Abbas AK, Weiss A. Akt provides the CD28 costimulatory signal for the up-regulation of IL-2 and IFN-gamma but not TH2 cytokines. Nat Immunol. 2001 Jan;2(1):37-44.


Fling SP, Sutherland RA, Steele LN, Hess B, D'Orazio SE, Maisonneuve J, Lampe MF, Probst P, Starnbach MN. CD8+ T cells recognize an inclusion membrane-associated protein from the vacuolar pathogen Chlamydia trachomatis. Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1160-5. PubMed PMID: 11158611; PubMed Central PMCID: PMC14725.


Su MW, Yu CL, Burakoff SJ, Jin YJ. Targeting Src homology 2 domain-containing tyrosine phosphatase (SHP-1) into lipid rafts inhibits CD3-induced T cell activation. J Immunol. 2001 Mar 15;166(6):3975-82. PMID: 11238643.


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2000


Wu X, Ranganathan V, Weisman DS, Heine WF, Ciccone DN, O'Neill TB, Crick KE, Pierce KA, Lane WS, Rathbun G, Livingston DM, Weaver DT. ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Nature. 2000 May 25;405(6785):477-82. PubMed PMID: 10839545.


Melián A, Watts GF, Shamshiev A, De Libero G, Clatworthy A, Vincent M, Brenner MB, Behar S, Niazi K, Modlin RL, Almo S, Ostrov D, Nathenson SG, Porcelli SA. Molecular recognition of human CD1b antigen complexes: evidence for a common pattern of interaction with alpha beta TCRs. J Immunol. 2000 Oct 15;165(8):4494-504. PubMed PMID: 11035089.


Tortorella D, Gewurz BE, Furman MH, Schust DJ, Ploegh HL. Viral subversion of the immune system. Annu Rev Immunol. 2000;18:861-926. Review. PubMed PMID: 10837078.


Furman MH, Ploegh HL, Schust DJ. Can viruses help us to understand and classify the MHC class I molecules at the maternal-fetal interface? Hum Immunol. 2000 Nov;61(11):1169-76. Review. PubMed PMID: 11137223.


McAdam AJ, Farkash EA, Gewurz BE, Sharpe AH. B7 costimulation is critical for antibody class switching and CD8(+) cytotoxic T-lymphocyte generation in the host response to vesicular stomatitis virus. J. Virology. 2000 74(1): 203-8. PMID: 10590107.


McAdam, AJ, Gewurz BE, Farkash, EA, Sharpe, AH. Either B7 costimulation or IL-2 can elicit generation of primary alloreactive CTL. J. Immunology. 2000 165(6): 3088-93. PMID: 10975820.


Tortorella D, Gewurz BE, Schust DJ, Furman MH, Ploegh HL. Down-regulation of MHC Class I Antigen Presentation by HCMV; Lessons for Tumor Immunology. Immunol. Invest. 2000. 29(2): 97-100. PMID 10854174.


Tortorella, D, Gewurz, BE, Furman, MH, Schust, DJ and Ploegh, HL. Viral Subversion of the Immune System. Ann Rev Immunology. 2000 18: 861-926. PMID 10837078.


Howland KC, Ausubel LJ, London CA, Abbas AK. The roles of CD28 and CD40 ligand in T cell activation and tolerance. J Immunol. 2000 May 1;164(9):4465-70.


Chen Z, Koralov SB, Gendelman M, Carroll MC, Kelsoe G. Humoral immune responses in Cr2-/- mice: enhanced affinity maturation but impaired antibody persistence . J Immunol. 2000. 164(9):4522-32.


Review Article: Chen Z, Koralov SB, Kelsoe G. Regulation of humoral immune responses by CD21/CD35. Immunol Rev. 2000;176:194-204. PMID: 11043778.


Kwon J, Morshead KB, Guyon JR, Kingston RE, Oettinger MA. Histone acetylation and hSWI/SNF remodeling act in concert to stimulate V(D)J cleavage of nucleosomal DNA. Mol Cell. 2000 Nov;6(5):1037-48. PubMed PMID: 11106743.


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