BBS Faculty Member - Jeffrey Macklis

Jeffrey Macklis

Max and Anne Wien Professor of Life Sciences, Harvard University;
Professor of Stem Cell and Regenerative Biology, Harvard University;
Professor of Neurology, Harvard Medical School





Harvard University
Bauer Laboratory 103
7 Divinity Avenue
Cambridge, MA 02138
Tel: 617-495-5413
Fax: 617-496-9679
Email: jeffrey_macklis@harvard.edu
Lab Members: 7 postdoctoral fellows, 4 graduate students
Visit my lab page here.



Our laboratory is directed toward both 1) understanding molecular controls and mechanisms over neuron sub-type development, diversity, axon guidance-circuit formation, and degeneration-disease in the cerebral cortex (e.g. corticospinal motor neurons - CSMN - in motor neuron disease - ALS, HSPs, and PLS; associative circuitry in autism-ASD), and 2) applying developmental controls toward both brain-spinal cord regeneration (e.g. corticospinal motor neuron (CSMN) circuitry that degenerates in ALS-MND, and whose injury is central to loss of motor function in spinal cord injury) and directed differentiation for in vitro therapeutic and mechanistic screening.

The lab focuses on neocortical projection neuron development and subtype specification; new approaches to subtype-specific axonal growth cone biology; neural progenitor / “stem cell” biology; induction of adult neurogenesis (the birth of new neurons); and directed neuronal subtype differentiation via molecular manipulation of neural progenitors and pluripotent cells (ES/iPS). Relationships and application of cortical development to evolution, disease, and regeneration are frequent themes.



Last Update: 11/16/2017



Publications

For a complete listing of publications click here.

 


 

Magavi SS, Leavitt BR, Macklis JD. Induction of neurogenesis in the neocortex of adult mice. Nature. 2000 Jun 22;405(6789):951-5.

Arlotta P, Molyneaux BJ, Chen J, Inoue J, Kominami R, Macklis JD. Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo. Neuron. 2005 Jan 20;45(2):207-21.

Molyneaux BJ, Arlotta P, Hirata T, Hibi M, Macklis JD. Fezl is required for the birth and specification of corticospinal motor neurons. Neuron. 2005 Sep 15;47(6):817-31.

Lai T, Jabaudon D, Molyneaux BJ, Azim E, Arlotta P, Menezes JR, Macklis JD. SOX5 controls the sequential generation of distinct corticofugal neuron subtypes. Neuron. 2008 Jan 24;57(2):232-47.

Azim E, Jabaudon D, Fame RM, Macklis JD. SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development. Nat Neurosci. 2009 Oct;12(10):1238-47.

Czupryn A, Zhou YD, Chen X, McNay D, Anderson MP, Flier JS, Macklis JD. Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice. Science. 2011 Nov 25;334(6059):1133-7.

Greig LC, Woodworth MB, Galazo MJ, Padmanabhan H, Macklis JD. Molecular logic of neocortical projection neuron specification, development and diversity. Nat Rev Neurosci. 2013 Nov;14(11):755-69.

Custo Greig LC*, Woodworth MB*, Greppi C, Macklis JD. Ctip1 controls acquisition of sensory area identity and establishment of sensory input fields in the developing neocortex. Neuron. 2016 Apr 20;90(2):261-77.

Galazo MJ, Emsley JG, Macklis JD. Corticothalamic projection neuron development beyond subtype specification: Fog2 and intersectional controls regulate intraclass neuronal diversity. Neuron. 2016 Jul 6; 91:90-106.
 
Shipman SL, Nivala J, Macklis JD, Church GM. CRISPR-Cas encoding of a digital movie into the genomes of a population of living bacteria. Nature. 2017.
 
Wuttke TV, Markopoulos F, Padmanabhan H, Wheeler A, Murthy V, Macklis JD. Developmentally primed immature neocortical neurons maintain fidelity and establish appropriate long-distance functional connectivity after micro-transplantation. Nat Neurosci. 2017; in press.




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of Harvard College