BBS Faculty Member - Patricia Donahoe

Patricia Donahoe

Department of Surgery

Massachusetts General Hospital
185 Cambridge Street CPZN 6206
Boston, MA 02114
Tel: 617-724-1600
Fax: 617-726-5057

Patricia K. Donahoe, M.D., is the Marshall K. Bartlett Professor of Surgery (HMS), Director Pediatric Surgical Laboratories (MGH), Associate Member of The Broad Institute, and a Principle Faculty Member at Harvard Stem Cell Institute. Her laboratory concentrates on developmental biology and the genetics of congenital anomalies. Her studies include sex differentiation and the role of Mullerian Inhibiting Substance (MIS), and the genetic causes of Congenital Diaphragmatic Hernia; her laboratory is also examining targetable differences between ovarian cancer stem cells and ovarian somatic stem cells and the role of MIS as a chemotherapeutic for ovarian cancer stem cells.

Last Update: 8/22/2013


For a complete listing of publications click here.



Wei X, Dombkoski D, Meirelles K, Pieretti-Van Marcke R, Szotek PP, Chang HL, Preffer FI, Mueller PR, Teixeira J, MacLaughlin DT, and Donahoe PK. Müllerian Inhibiting Substance preferentially inhibits stem/progenitors in human ovarian cancer cell lines compared to chemotherapeutics. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18874-9. PMCID: PMC2973919.

Kantarci S, Al-Gazali L, Hill RS, Donnai D, Black GC, Bieth E, Chassaing N, Lacombe D, Devriendt K, Teebi A, Loscertales M, Robson C, Liu T, MacLaughlin DT, Noonan KM, Russell MK, Walsh CA, Donahoe PK, Pober BR. Mutations in LRP2, which encode the multiligand receptor megalin, cause Donnai-Barrow and facio-oculo-acoustico-renal syndromes. Nat Genet. 2007 Aug;39(8):957-9.

Kantarci S, Ackerman KG, Russell MN, Longoni M, Sougnez C, Noonan KM, Hatchwell E, Zhang X, Pieretti-Vanmarcke R, Anyane-Yeboa K, Dickman P, Wilson J, Donahoe PK, Pober BR. Characterization of the Chromosome 1q41q42.12 region and the Candidate Gene,
DISP1, in Patients with CDH. Am J Med Genet A. 2010 Oct;152A(10):2493-504.

Szotek P, Chang HL, Brennand K, Fujino A, Pieretti-Vanmarcke R, Lo Ceslo C, Dombkowski D, Preffer F, Cohen K, Teixeira J, Donahoe PK. Normal Ovarian Surface Epithelial Label Retaining Cells Exhibit Stem/Progenitor Cell Characteristics. PNAS 2008; 105(34):12469-12473. PMCID: PMC2527935.

Szotek PP, Pieretti-Vanmarcke R, Masiakos PT, Dinulescu DM, Connolly D, Foster R, Dombkowski D, Preffer F, Maclaughlin DT, Donahoe PK.Ovarian cancer side population defines cells with stem cell-like characteristics and Mullerian Inhibiting Substance responsiveness.Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11154-9.

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